"Paroxetine": yokusetshenziswa, ukubuyekezwa. izidakamizwa analogue

Asho izidakamizwa "Paroxetine"? Yokusetshenziswa zomuthi izokwethulwa kulesi sihloko. Futhi vele bati iyiphi contra-izinkomba futhi zitholakala kuphela kusuka kule imithi, uma kuye kwadingeka yini imiphumela emibi, kulokho ifomu iyatholakala futhi indlela izidakamizwa baxhumana nezinye izidakamizwa.

Ukwakheka, emabhokisini futhi ifomu wokukhulula izidakamizwa

Izidakamizwa "Paroxetine" kuqhubeka ukudayiswa ngesimo amaphilisi, ifilimu-camera. Ziyakwazi ukuma isiyingi futhi we-lenticular wangakwesokunxele, umbala omhlophe, futhi ingozi surface olunzima.

Ingqikithi asebenzayo kubhekwa yithi kusho paroxetine hydrochloride hemihydrate. Futhi, izidakamizwa e ngezithako zawo inezici ukwesekwa ngesimo colloidal Silicon dioxide, microcrystalline cellulose, crospovidone, i-calcium hydrogen phosphate, copovidone, talc kanye magnesium stearate.

Tablets "Paroxetine" zidayisa ibhamuza amaphakethe of izingcezu 10 okuyinto ezibekwe ebhokisini amakhadibhodi.

Isenzo kwemithi zomuthi

Uyini izidakamizwa "Paroxetine", okuyinto analogue uzobe kancane okuthiwa okunye? Kuyinto antidepressant. Kuyinto inhibitor ka (abakhethayo) serotonin izinzwa reuptake ingqondo. Yilokhu inquma imiphumela yayo anti-bacindezeleke nokusebenza ngempumelelo ekwelapheni uvalo isiyaluyalu nayo iziyaluyalu esilawulayo-abayimilutha.

Okubukwe xhumana nomuthi has ziyezwana ongaphakeme kakhulu α2-, α1- futhi β-adrenoreceptors kanye m-holinoretseptorami, Dopamine, 5HT1-like, 5HT2-like futhi histamine H1-receptor.

Ingabe lengqondo imisebenzi kwephula izidakamizwa "Paroxetine"? Uphenyo odokotela bathi umuthi akunamthelela psyche womuntu omubi. Ngaphezu kwalokho, lokho akusho potentiate imiphumela nokudangala of ethanol ku lengqondo imisebenzi.

Kusolakala abacwaningi baye bathola i antidepressant enjalo ababuthakathaka Kuvuselela izakhiwo kuphela uma iqondiswa at imithamo ngaphezu kwalawo adingekayo okusithiyayo we-serotonin reuptake. Asinakusho ukuthi lokhu izidakamizwa akakubangeli ukushintsha okuphawulekayo endleleni amazinga blood pressure, Bheka nokushaya kwenhliziyo.

I pharmacokinetics sedivayisi yezokwelapha

izidakamizwa "Paroxetine" njengoba ugxile? Yokusetshenziswa, odokotela yangempela ukuthi ngemva kokuphathwa ngomlomo we ketshezi esebenzayo amuncwa umzimba kusukela ipheshana yesisu futhi akheka ngokusebenzisa isibindi.

Ubuningi umile ka nomuthi egazini kufezwa ngokusebenzisa amasonto 1-1.7 emva emizameni yokuthuthukisa imithi. Isithako asebenzayo zomuthi lisasetshenziswa kwasakazwa kwezicubu. Kulokhu, kubalulekile ngephesenti elilodwa kuphela butholakala plasma. Ukuxhumana namaprotheni komyalelo wokungabi 95%.

Antidepressant akheka esibindini. Ngenxa yalokho, metabolites ngasebenzi akhiwa. Ngokushesha aphume emzimbeni, futhi ube umsebenzi ongaphakeme kwemithi futhi ube akunamthelela imiphumela oqabulayo izidakamizwa.

izidakamizwa "Paroxetine" njengoba kuboniswa? Qaphela, osokhemisi izilinganiso asho ukuthi cishe ngo-64% we ketshezi esebenzayo kukhishelwa kanye umchamo, kuyilapho asele 36% - emathunjini (e Bile).

I pharmacokinetics zomuthi ezimweni emitholampilo ekhethekile

Ubuningi lomcebo asebenzayo plasma inyuka ephula izinso futhi isibindi, kanye nasebekhulile.

Izinkomba ngokusetshenziswa idivayisi yezokwelapha

Kwezinye izimo, iziguli kuyabekwa antidepressant "Paroxetine"? ku isicelo yomhlahlandlela ithuluzi iqukethe uhlu elandelayo ukufundwa:

• yimuphi uhlobo oluthile lokucindezeleka, kuhlanganise endogenous ezinzima, esisheshayo, kanye kuhambisana ukukhathazeka;
• netwetwe zempilo, kuhlanganise agoraphobia;
• disorder esilawulayo-kuphoqeleke (OCD noma esifushanisiwe);
• Ukukhathazeka Okuvamile;
• kuthi- wani ngenkinga yokukhathazeka komphakathi, noma okuthiwa kwabokufika nomphakathi.

Izimo ukusetshenziswa idivayisi yezokwelapha

Kwezinye izimo, akunakusetshenziswa ayikwazi isetshenziswe ezigulini antidepressant "Paroxetine"? ku isicelo yomhlahlandlela ithuluzi kuhlanganisa uhlu elandelayo Izimo:

• isithuthwane engazinzile;
• ukusetshenziswa ngesikhathi esifanayo monoamine oxidase inhibitor, kanye nesikhathi esingamasonto amabili ngemuva ehoxile;
• ubudala zezingane;
• isikhathi sokukhulelwa;
• Hypersensitivity kuya izingxenye izidakamizwa;
• ngesikhathi sokuncelisa ibele.

Sebenzisa ngokucophelela okukhulu

Ngaphansi kwaziphi izimo kufanele edonsa antidepressant "Paroxetine" elawulwa? Yokusetshenziswa uthi lokhu ukulungiselela iqondiswa ngokuqapha iziguli yokwehluleka kwesibindi, engela-Ukuvalwa ukufiphala ukwehluleka kwezinso, mania, ingozi Hyperplasia Prostatic, uthi convulsive, iziyaluyalu zenhliziyo, isifo sokuwa. Ngaphezu kwalokho, ukusetshenziswa ngesikhathi esifanayo imithi ayivumelekile futhi cardioversion, kanye imithi ukuthi kwandisa ingozi yokungenwa ukopha. Kufanele sinake ethile yokubakhona engcupheni iziyaluyalu ukopha futhi kunikela ezifana isifo uthi.

Antidepressant "Paroxetine": kanjani ukuthatha imithi?

Sicabanga imithi esithathwayo ngomlomo kanye ngosuku (ekuseni) ngesikhathi sasekuseni. Tablets kufanele kugwinywe lonke, wageza phansi ngamanzi plain.

Phakathi namasonto okuqala amathathu ngemuva kokuqala ukwelashwa umthamo is kushintshwe ngamunye. It is kamuva kushintshwe (uma kunesidingo).

Phakathi isikhathi eside ukucindezeleka lemali Kunconywa we nomuthi 20 mg kanye ngelanga. Uma kudingeka, umthamo liyakhula kancane kancane ngo-10 mg. Max wathola izidakamizwa kumele singeqi mg 50.

Ukuze kuphoqeleke disorder esilawulayo umthamo kokuqala i antidepressant 20 mg ngosuku. Ngemva kwalokho, kwandisa-10 mg. I Kunconywa isilinganiso umthamo wansuku zonke ukuze ukuphambuka esinjalo siyisivikelo 40 mg. Ngo isidingo acute kungaba senyukela mg 60.

Uma isiguli sine-disorder ukwethuka, ungakwazi ekuqaleni kuthathe 10 mg zomuthi ngosuku. Ukuze kuncishiswe ingozi kungenzeka izimpawu ukwesaba umthamo okwalandela zomuthi luyanda 10 mg. Ngokwesilinganiso, lapho ukuphambuka enjalo uyamukeleka zisebenzisa 40 mg "paroxetine" ngama-iri, inombolo enkulu - 50 mg.

Lapho kwabokufika yezenhlalakahle noma ukukhathazeka komphakathi iziyaluyalu nomuthi ivolumu kokuqala kumele singeqi 20 mg ngosuku. Uma emva ukwelashwa okunjalo nomphumela ofiselekayo engakaze kufinyelelwa, bese 2 amaviki umthamo liyakhula kancane kancane kuze kufike ku, okungukuthi kufika ku-50 mg ngosuku.

Ngo ukukhathazeka okuvamile zokwelapha kanye ivolumu kokuqala nomuthi 20 mg ngelanga

Uma isiguli sekutholakele ukuthi sine- isibindi noma ukungasebenzi kwezinso, umthamo watusa kufanele kube 20 mg ngosuku.

Abantu abadala ngosuku ingagxila kungekho mg engaphezu kwengu-40 imithi.

Ukuze uvimbele nokuqaleka ukuziyeka izidakamizwa Kunconywa kancane kancane.

amacala ukweqisa izidakamizwa

Zikhona amacala ukweqisa izidakamizwa ne antidepressant ezifana "Paroxetine", "Fluoxetine"? Ochwepheshe uqaphele ukuthi ukusetshenziswa inqwaba amaphilisi bona ngempela zibulale umzimba womuntu. Isiguli isipiliyoni isicanucanu, nomlomo owomile, itheku tachycardia, ukuhlanza, Ukudlikizela, liqhaqhazela, bradycardia, mydriasis, ukuyaluza, ukucasuka, ukujuluka, nystagmus, kukhuphuke blood pressure, somnolence, nesigci nodal.

Ezimweni sasivumela ezingavamile ngenkathi usebenzisa izidakamizwa nezinye izidakamizwa psychotropic, futhi utshwala bungabenza comatose nesineke kanye ukushintshashintsha inkomba ku ECG. Ngo ukweqisa izidakamizwa ezinzima, isiguli serotonin syndrome futhi rhabdomyolysis.

Okufanele ukwenze ezimweni ezinjalo? Endabeni izidakamizwa ukweqisa izidakamizwa "Paroxetine" kufanele kube lavage esiswini thatha carbon isebenze. Uma kunesidingo, ukuphathwa lingaze.

side effects

Yiziphi imiphumela emibi imithi kungabangela "Paroxetine"? Uphenyo odokotela bathi leli thuluzi kuyasiza ngempela ukuthuthukisa ukusabela ezingezinhle. Lezi zihlanganisa izimo nezifo ezilandelayo:

• On the ingxenye isimiso sezinzwa esiyinhloko kanye neuropathy isimiso sezinzwa: mania, ukozela, ukudideka, liqhaqhazela, serotonin syndrome, ukukhathala, ukuhhema, ukuqwasha, uvalo, isiyezi, depersonalization, ukukhathala, ukushaywa uvalo ngaphandle kwesizathu sokuwa ukuyaluza, ukulahlekelwa amandla okukhumbula, disorder extrapyramidal, myoclonus, ukukhathazeka.
• uhlelo zemisipha: buthakathaka kwezicubu, arthralgia, myopathy futhi myalgia.
• Imiqondo: angaboni kahle futhi esilufifi iyonke.
• uhlelo urinary: ukuchama kaningi noma nokugcinwa urinary.
• ipheshana wokugaya ukudla: anda noma kwehle esesuthi, isifo sokusha kwesibindi, ukunambitheka ushintsho, nomlomo owomile, isicanucanu, uhudo, ukuhlanza, futhi ukuqunjelwa.
• uhlelo ezalayo: anorgasmia, nezinkinga zobulili, hyperprolactinemia noma galactorrhea, ubuthakathaka kanye ejaculation iziyaluyalu.
• Isimiso senhliziyo nemithambo yegazi: hypotension orthostatic.
• Yokungezwani komzimba: ukulunywa, ukuqubuka, angioedema futhi urticaria, ecchymosis.
• Okunye ukuhlukahluka: rhinitis, ukujuluka, uketshezi ezingafanele i-hormone antidiuretic, hyponatremia.

Ukuxhumana nezinye izindlela zokwelapha

Ukusetshenziswa ngesikhathi esisodwa antacids akuphazamisi imingcele pharmacokinetic kanye ukumuncwa lesi sidakamizwa "Paroxetine".

Contraindicated ukusetshenziswa yesikhathi esisodwa kwezimali phambi kwethu nge Mao inhibitor.

reception esisodwa nomuthi "paroxetine" nge izidakamizwa ukuthi zivimbela enzyme isibindi, kudinga ukwehlisa komthamo wokuqala.

alula Antidepressant ukopha engxenyeni ngemuva ukusetshenziswa yesikhathi esisodwa "ka warfarin."

ukusetshenziswa ngesikhathi esisodwa nomuthi "paroxetine" nge tricyclic antidepressant, aspirin, neuroleptics atypical, ama-NSAID futhi kusho phenothiazine uchungechunge ikhuthaza igazi ekunqandeni inqubo.

ekuphathweni Ngesikhathi serotonergic ejenti (ezifana "tramadol" futhi "sumatriptan") engase iholele kalula sithuthukiswe serotonergic imiphumela.

Kubalulekile ukukhumbula!

Ukuze ugweme ukuthuthukiswa a syndrome neuroleptic (abulalayo), umuthi nge ngokwedlulele ngokuqapha "Paroxetine" okunqunyiwe iziguli ezidla antipsychotics.

Abantu abadala ku isizinda izidakamizwa angagcina hyponatremia.

Lapho izimpawu zokuqala nokuquleka nokwelulekwa mania antidepressant imisiwe.

Phakathi namasonto okuqala ukwelashwa nge "paroxetine" idinga ukuqapha ngokucophelela isiguli ngenxa yokuthi kungenzeka ukuthi ukuzibulala.

Phakathi ukwelashwa kufanele uyeke utshwala ngenxa umphumela zabo enobuthi ukugqanyiswa.

ukusetshenziswa Pediatric

Izidakamizwa "Paroxetine" akukashicilelwa izingane, njengoba nokuphepha yayo kanye kusebenta ekwelapheni iziguli kuleli qembu sezisunguliwe cha.

Antidepressant "Paroxetine": nozakwabo

Umuthi kungenziwa indawo "Paroxetine"? Kumele kuqashelwe ukuthi le imithi, baningana nozakwabo ambalwa. Phakathi kwabo, kuyoba ezifiselekayo ukugqamisa izidakamizwa ezilandelayo: "Reksetin", "Adepress", "Pliz", "Apo-Paroxetine", "Aktaparoksetin", "Paxil", "sertraline", paroxetine hydrochloride hemihydrate, "" Sirestill "nokunye.

Ukuze uthenge zonke lezi imithi ekhemisi, unga kuphela kadokotela.

Uphenyo nomuthi

Izidakamizwa "Paroxetine" has a lot of Izibuyekezo exubile, kokubili kusuka ochwepheshe kanye ezigulini. Ngakolunye uhlangothi, it is ukunconywa lokho kunomthelela nokuqedwa okusheshayo yimuphi uhlobo oluthile lokucindezeleka (kuhlanganise endogenous ezinzima, esisheshayo, kanye kuhambisana ukukhathazeka), kanye ukwethuka, esilawulayo-abayimilutha, generalized nezenhlalo-abanenkinga yokukhathazeka. Ngakolunye - iziguli eziningi bathi ngokushesha ngemva izidakamizwa bahlakulela ngempela inqwaba ukusabela ezingezinhle. Ngenxa yalokho, abantu kwadingeka ngisho ukuyeka impatho.

Ngokuvamile, ochwepheshe uqaphele ukuthi "Paroxetine" - lena izidakamizwa ngempumelelo kakhulu futhi kuwusizo ubhekana umsebenzi eyabelwe yona. Nokho, ingasetshenziswa kuphela owawudalelwe injongo onguchwepheshe.