Nitrofurantoin: yokusetshenziswa, intengo

Kuyini lokhu izidakamizwa njengoba nitrofurantoin? Yokusetshenziswa kwalesi sakhi izokwethulwa ngezansi.

chemical izakhiwo

Yini izakhiwo nobuntu ekhuthaza ezifana nitrofurantoin? Iziyalezo yokusetshenziswa uthi kuba esuselwe nitrofuran. Kubonisa evelele izakhiwo elwa namagciwane. Ngokuvamile, izidakamizwa kanye isakhi ezifana isetshenziswa ukuze yelaphe izifo ezibangelwa endaweni urogenital.

Izakhiwo kanye ukuma

Kuyini nitrofurantoin? Imiyalelo isicelo zokubuyiselwa, okuyinto crystalline powder esawolintshi noma ephuzi, okuyinto kunobuciko ethize ezibabayo. Le ngxube kakhulu kabi encibilikayo hhayi kuphela emanzini kodwa futhi i utshwala.

Ngayiphi amafomu ezikhishwe izidakamizwa ahlanganisa njengoba nitrofurantoin? Izibuyekezo babike ukuthi lezo zimali zenziwa ngendlela amaphilisi angefani. Kungenzeka enteric-camera noma ukukhiqizwa ngaphandle kwalo.

pharmacodynamics

Nitrofurantoin (inani lentengo lomuthi yalolu ketshezi aboniswe ngezansi) libonisa amagciwane kanye izakhiwo elwa namagciwane. Le into kuvimbela amaprotheni zamagama izinqubo, ribonucleic futhi acid deoxyribonucleic futhi kunciphisa permeability of cell ulwelwesi kanye ukushuba umzimba (aerobic) namagciwane ayingozi.

Pharmacokinetics

Yini kinetic izakhiwo ejwayelekile isakhi ezifana nitrofurantoin? Iziyalezo yokusetshenziswa uthi yalolu ketshezi kakhulu ukumuncwa umthamo. bioavailability Its 50%. Ngaphezu kwalokho, ukusetshenziswa ukudla kwandisa izinga.

Ngokusho ochwepheshe, ezincane zinhlayiya ka wathi chemical kwakwakhe, ngcono bangancibilika futhi lingene egazini.

Mayelana 60% ingxenye okukhulunywa nakanjani plasma amaprotheni. umzimba wayo e nezicubu isibindi, futhi ukuqedwa isigamu-ukuphila imayelana 25 imizuzu.

ubufakazi

Amalungiselelo nge lodaba ebekiwe kulezi zimo ezilandelayo:

• Prevention at cystoscopy, catheterization, nezinye ukuhlinzwa urologic nocwaningo.
• Ukwelapha izifo emkhakheni urogenital (isib cystitis, pyelitis, pyelonephritis, urethritis).

Enqabelo ukuthola

Nitrofurantoin is contraindicated ukusebenzisa:

• lapho oliguria;
• obonakaliswe izinso iziyaluyalu;
• ukhulelwe;
• inhliziyo esingamahlalakhona noma ukwehluleka kwezinso;
• yokuntuleka zikashukela-6-phosphate dehydrogenase;
• yokungezwani komzimba ukuze ketshezi;
• kuze kube inyanga eyodwa ubudala;
• ukusha kwesibindi kohlobo esingamahlalakhona noma isifo sokusha kwesibindi;
• porphyria acute;
• lactation.

ngokuqapha elithile kufanele libukwe in iziguli isifuba somoya bronchial, futhi khona izinguquko fibrotic e yamaphaphu.

Nitrofurantoin: yokusetshenziswa

Inani imikhiqizo ngalolu ketshezi esebenzayo akuyona eliphezulu kakhulu. Uma kwakukhulunywa kabi ekhishwe ngesimo amaphilisi, amiswa onguye ngaphakathi, ukuphuza uketshezi oluningi. Ngokuvamile, izidakamizwa ezinjalo iphathwa iziguli ngesikhathi umthamo 50-150 MG kane ngosuku. Inkambo yokwelashwa nale ejenti kumele kutsatse izinsuku 5-7.

esiphezulu I umthamo owodwa ukuba umuntu omdala kuyinto 0.3 amagremu ngosuku zingasebenzisa kuze kufinyelele 0.6 mg nomuthi.

Izingane le imithi enqunyiwe 5-8 mg amakhilogramu esisindo ngayinye. Umthamo wansuku zonke zomuthi ehlukaniswa 4 ngemithamo ahlukaniswe.

Uma wayefisa, i-ejenti ukwelashwa okunjalo kungase enwetshiwe izinsuku ezingu-10. Nokho, lokhu kudinga ukulawula inzalo ka umchamo.

uhlangothi imihlola

Emva kokuthola nitrofurantoin e isiguli bangezwa:

• uhudo, isifo sokusha kwesibindi, syndrome cholestatic, pancreatitis, enterocolitis pseudomembranous;
• ukuhlanza, isicanucanu, isiyezi, ubuhlungu bekhanda;
• ukukhathala, arthralgia, nystagmus, myalgia, ukushaqeka anaphylactic;
• eosinophilia, syndrome volchanopodobny, ukuqubuka kwesikhumba, Ukugodola;
• ukukhwehlela, imfiva, ukozela, isimiso bronchial, webele isisa interstitial wamaphaphu kwezinso;
• Ubuhlungu obukhulu besisu, peripheral neuropathy.

Ngekusetjentiswa eside zomuthi kwandisa ingozi yomdlavuza ngo izinso.

izincomo ezithile

Abantu ne electrolyte ukungalingani, ukuntuleka kwegazi emzimbeni, isifo sezinso, kanye nokuntuleka amavithamini B abe amathuba enkulu yokuba lesi-peripheral neuropathy.

Udaba ndaba ayizwakali ekwelapheni prostatitis, izifo cortex kwezinso futhi ubovu paranephritis.

Leli thuluzi asifanele ukuhlanganisa imithi ukuthi ahlinzeke ithonya elibi nokusebenza kwezinso.

Izindleko kanye nokubuyekeza

kanjani amalungiselelo ngempahla ezifana nitrofurantoin? Intengo izindlela ethandwa kakhulu - "furadonin" - kuyinto ruble ngu-120.

Ngokusho izimpendulo iziguli nokubika ingxenye iziphatha kahle cystitis. Nokho, kufanele kuphawulwe ukuthi nedili lomshado nabo nitrofurantoin imithi bavame ukubanga ubuhlungu bekhanda, ubuhlungu besisu, ukuhlanza okungapheli nesicanucanu.