"Misoprostol": ama-analogues, imiyalo, ukubuyekezwa

Isidakamizwa esithi "Misoprostol" siyindlela ephumelela kakhulu futhi ethandwayo ongayenza ukukhipha isisu. Ukuze le nqubo yenziwe ngendlela efanele, imithi emibili kufanele isetshenziswe ngesikhathi esisodwa: i-Mifepristone ne-Misoprostol. Ama-analogues ala mithi ongayithola kunoma yiliphi ikhemisi, kodwa akunconywa ukwenza isinqumo ekusebenziseni kwabo ngokwabo.

Isimiso esiyinhloko sesenzo samathebulethi "iMisoprostol" sisekugqugquzelweni kwe-uterine contraction. Futhi lokhu, kukhuthaza ukuphuma kwangaphambi kwesikhathi kweqanda le-fetal. Kodwa uma uthathe imithi efana ne-Mifepristone ezinsukwini ezimbili, unganikeza insizakalo yokuqhaqhazela phansi.

Indlela umuthi usebenza ngayo

Amaphilisi "Misoprostol", okufana nawo okushiwo ngezansi, yi-prostaglandin yokwenziwa eqenjini E. Ngokuhlushwa okulungile, i-hormone prostaglandin iqala ukukhiqizwa ngenkuthalo emzimbeni. Nguye okwazi ukuvuselela ukuqala kokubeletha.

Futhi, lesi sidakamizwa sivame ukusetshenziselwa izifo zezinkinga kulezi zimo lapho inqubo yokubeletha ingane ithatha isikhathi eside kakhulu, futhi lokhu kunomthelela omubi empilweni yengane.

Ngokusebenzisa i- "Misoprostol" (okufana nezidakamizwa - izidakamizwa ezine-ATS-code efanayo) ezinkathini zokuqala zokukhulelwa, kungenzeka futhi ukuvusa ukuqala kokuzalwa ngaphambi kwesikhathi.

Singasho ukuthi lesi sidakamizwa sinomthelela okhohlisayo emzimbeni wesifazane. Lapho ukuphela kokukhulelwa kudlulela, i-prostaglandin ikhiqizwa emzimbeni ngokwayo ngenxa yohlu lwe-fatty acids. Noma kunjalo, umzimba ungadukiswa usebenzisa amaphilisi "Misoprostol" ngale njongo. Ama-analogues "i-Cytorek", "i-Mirolyut" nayo ifaka isandla ekusenikeni kokuzalwa ngaphambi kwesikhathi.

Lapho izinto ezisebenzayo zezidakamizwa zikhona ohlelweni lokujikeleza, izitho zokubeletha ziqala ukulungiswa ngenqubo yokulethwa kwezidingo. Ngaphezu kwalokho, isikhathi sokukhulelwa asibaluleki neze, ngoba umzimba uqala ukucabanga ukuthi ingane ivele isungulwe ngokugcwele.

Imiyalo yokusebenzisa amaphilisi "Misoprostol"

Ama-analog of "Misoprostol", njengezidakamizwa ngokwawo, kubaluleke kakhulu ukuthatha kahle. Ngeke kuxhomeke ekufundeni okulungile kwenkambiso yokulethwa kwezidingo, kodwa nakwezempilo yowesifazane uqobo.

Ngokwemiyalelo yokusetshenziswa, kanye neseluleko sabesifazane besifazane, kufanele uqale uthathe amaphilisi amathathu e-"Mifepristone", bese ulinda amahora angu-40 nesishiyagalolunye. Futhi ngemva kwalokho udinga ukuthatha ama-milligram amane "we-misoprostol". Ngokuvamile, le milingo iqukethe amaphilisi amabili.

Ngaphezu kwalokho bonke badlula ngokukhethekile ngabanye. Ngokujwayelekile, emva kwamahora ambalwa, lo wesifazane uqala ukuphuma e-utero. Lokhu kusikisela ukuthi i-mucosa ye-uterine inqatshiwe kanye neqanda lomntwana ngokwayo. Okusho ukuthi inqubo yokukhipha isisu kuqala.

Ngokuvamile ngemva kokusebenzisa lesi sidakamizwa, abesifazane bayaqaphela ukudonsa ubuhlungu emathunjini aphansi, kanye nokukhishwa kwamanzi amancane, okugeleza kahle ekuphumeni kwegazi. Ngokuvamile, lezi zimpawu zenzeka esikhathini esingakapheli amahora amabili emva kokuba umuthi usetshenziswa. Kodwa-ke, kwabanye besifazane bangabonakala ngemva kwamahora amabili namane kuphela. Lokhu kuthathwa njengokujwayelekile. Umphumela onjalo unikezwa amaphilisi "Misoprostol". Ama-analog of the generic "Saitotec" ne "Mirolut" anomphumela ofanayo, ngoba une-prostaglandin ekubunjweni kwawo.

Odokotela batusa ukwenza i-ultrasound, kanye nokuhlolwa kokubeletha esisodwa kuya kwamasonto amabili emva kwalesi senqubo. Lokhu kwenziwa ukucacisa imiphumela yokukhipha isisu.

Yiziphi izici ezithinta ukuphumelela

Ngokuvamile ukuphumelela kokukhipha isisu kuthinteka ngokuqukethwe okuphezulu kwamahomoni wesifazane ocansini emzimbeni. Njengoba wazi, i-progesterone inesibopho sokulungiselela umzimba wesifazane ukukhulelwa. Ngakho-ke, uma inombolo yayo yanda, uhlelo lokuzala luzophikisana nalolu hlobo lokukhipha isisu.

Njengoba okuqukethwe okungezansi kwama-hormone wesifazane wesifazane, inqubo ivame ukulula. Ngalesi simo, abanye besifazane baqala ukukhipha isisu.

Qinisekisa ukuthi uqaphele ukuthi le ndlela yokukhipha isisu inqunywe ngemuva kokuhlolwa okuphelele komzimba wesifazane. Kuvela kokuqukethwe kwe-progesterone kuyo ukuthi umthamo wesidakamizwa uzoncika.

Pharmacokinetics

Isivinini sesenzo samathebulethi okuthiwa "Misoprostol" (imiyalelo yokusetshenziswa, ukubuyekezwa, izifaniso ezichazwe kulesi sihloko) kuxhomeke kulokho intombazane idla. Uma ummeli wezocansi ezifanele ngaphambi kokuthola izimali adle inani elikhulu lamafutha, izinto ezisebenzayo zizoqala ukungena egazini ngokulibaziseka okuncane. Ngokujwayelekile imizuzu engamashumi amathathu kuya kwamashumi ayisithupha.

Ukungena emathangeni emathunjini kanye nesibindi, izakhi ezivela ku-prostaglandin yokufakelwa zibizwa nge-biotransformed ngokwemvelo, ziphenduke zibe i-misoprostolic acid. Kungenxa yalokhu ukuthi ukukhiqizwa kwe-prostaglandin kuqala. Ngokuvamile, emva kokukodwa nesigamu kuya emahoreni amabili, ukuphuma kwegazi kuqala, kuhambisane nokukhululwa kwezingcingo ze-turbid kanye ne-fetus ngokwayo.

Ukulawulwa okugunyaziwe kwemiphumela

"Misoprostol", isenzo esichazwe ngokuningiliziwe kule ngqungquthela, akude njalo iphumelele. Kukhona isigaba sabesifazane abangenandaba nalesi sidakamizwa, ngakho akunakwenzeka ukukhuthaza ukukhipha isisu.

Umuntu angaqonda kanjani ukuthi inqubo ayizange ibe nomphumela omuhle? Qaphela izimpawu ezinjalo:

• Ukungabi nokuphuma kwegazi kungakapheli amahora ambalwa emva kokusetshenziswa kwesidakamizwa;
• Ngaphansi kwesisu asikho ukuzwa okungathandeki kwemvelo ephazamisayo.

Kungabe kube nemiphumela emibi?

Isidakamizwa esithi "Misoprostol" (imfundo, ama-analogs anikezwe kulesi sihloko) ngokuvamile kuvame ukwakhiwa kwemiphumela emibi. Amantombazane amaningi akhononda ngesifo sohudo nesifo se-digestive tract. Uma bekungekho izibonakaliso ezinjalo, cishe, cishe umuthi awuzange usebenze nhlobo.

Uma kunjalo, hamba esibhedlela ngokushesha. Mhlawumbe udokotela wakhotha umthamo ongalungile. Uma uhlobo lwezokwelapha lokukhipha isisu luphumelelanga, khona-ke uzonikezwa indlela yokungenelela kokuhlinzwa.

Ingabe umzimba udinga ukubuyiselwa ngemuva kwenqubo?

Ama-analog of "Misoprostol" ekhemisi ukuthenga kulula. Kodwa ingabe kufanele? Akusekho icala ungathathi isinyathelo kule ndaba. Kusobala ngokuvumelana nazo zonke izincomo zikadokotela wakho, ngaphandle kwalokho ubungozi obungozi obukhulu empilweni yakho.

Ukwenza isisu sokukhipha isisu kuyinkimbinkimbi kakhulu edinga ukubuyiselwa komzimba. Ngokuyinhloko, isimiso se-endocrine sihlaselwa. Kodwa-ke, "i-Misoprostol" kakhulu ixoshwa ngokushesha emzimbeni.

Ngokusho odokotela, ukubuyisela ngokugcwele umzimba wesifazane kuzothatha cishe amasonto amane kuya kwahlanu. Uma ekupheleni kwalesi sikhathi esikhathini sokuya esikhathini singakaqali, qiniseka ukuthi ubona udokotela futhi ubeka imbangela.

Isikhathi sokubuyiselwa akuxhomeke kuphela kwizici zomuntu ngamunye, kodwa nangesikhathi sokukhulelwa. Sicela uqaphele, isikhathi eside, isikhathi esiphezulu se-progesterone, okumele kusetshenziswe kakhulu ukuhlushwa kwemithi esebenzayo.

Ama-analogues

Isidakamizwa esithi "Misoprostol" sinenombolo enkulu yezifaniso, ezinemisebenzi efanayo. Zonke zinesakhiwo se-hormonal futhi zithathwe ku-prostaglandin. Le ngxenye iholela ekunciphiseni kwesibeletho. Zonke izidakamizwa ezihloselwe ukukhipha isisu kulesi sakhiwo se-misoprostol. Cabangela othandwa kakhulu kubo.

"Saitotec". Leli thuluzi linconywa odokotela hhayi kuphela ukukhipha isisu, kodwa futhi nokwelashwa kwezifo zezilonda zesilonda.

Isidakamizwa sisetshenziselwa ukukhipha isisu, kanye nasesikhathini "sokukhulelwa" okukhulelwe. Kodwa-ke, njengasendabeni kaMisoprostol, iSaitotec kufanele isetshenziswe kuphela ngokubambisana noMifepristone.

"Mirolyut". Umuthi ophephile, ngoba awuthinti uhlelo lwama-hormonal wesifazane. Kodwa-ke, sicela uqaphele ukuthi naphezu kwalokhu, ungasebenzisa imithi kuphela ngaphansi kokuqondisa okuqinile kwegciwane lamazinyo.

Kunezinye izifaniso zokulungiselela "Misoprostol", njenge "Cytotec", "Mizonuvel." Zonke zitholakala ngesimo samathebulethi nge-200 μg yezinto ezisebenzayo.

"Misoprostol": ukubuyekezwa kwabesifazane

Ukukhipha isisu ngezidakamizwa "Misoprostol", kanye nezifanekiselo zalo - kuyindlela ephephile futhi eqinisekile yokukhipha isisu. Ngokusho kwabesifazane abathathe lesi sidakamizwa, emva kwalendlela yokukhipha isisu, ungakhulelwa futhi ubelethe umntwana ophilile ngokuphelele, okuhlanganisa kakhulu kakhulu.

Odokotela banikeza lo muthi kuphela emva kokuhlola okuphelele. Okufishane isikhathi sokubeletha, inqubo iphephile futhi isebenza kahle.

Kunoma yikuphi, cabanga ukuthi ungaphazamisa ukukhulelwa. Uma unquma ukuthi kusekufanele, ukukhipha isisu ngokwemithi "Misoprostol" kuyoba yisisombululo esihle kakhulu. Yiba nempilo futhi uzizinakekele, futhi izindlela ezinjalo ezinamandla ngeke ziwusizo kuwe.