"Levodopa / benserazide-Teva": yokusetshenziswa, analogs kanye nokubuyekeza

Yini engathatha isikhundla sale izidakamizwa njengoba u- "L-Dopa / benserazide"? Analogue lomutsi Kamuva sizoxoxa ngokuthi esihlokweni. Sizophinde ukwethula izici kwemithi kwaleli thuluzi, injalo woyekelo, izinkomba nezindlela zokusebenzisa.

Ifomu, ukubunjwa, emaphaketheni

I nomuthi "levodopa / benserazide-Teva", ukulaya is ebiyelwe ebhokisini amakhadibhodi kukhishelwa ngesimo amaphilisi, zahlanganiswa ngo amabhodlela 30, 20, 60 noma 50 izingcezu. Ingqikithi oyinhloko we levodopa izidakamizwa futhi benserazide aphume ashone. Ngokuphathelene izingxenye ezengeziwe, zihlanganisa: mannitol, i-calcium hydrogen phosphate (anhydrous), i-MCC, crospovidone, isitashi ummbila pregelatinized, colloidal Silicon dioxide, povidone K25, magnesium stearate, kanye obomvu oxide colorant ferric.

izici kwemithi

Ukulungiselela "levodopa / benserazide" limelela kuhlanganiswe ejenti antiparkinsonian okuhlanganisa ukubunjwa yayo le decarboxylase inhibitor (neuropathy) elimnandi L-amino acid kanye Dopamine eyandulela.

Ngo parkinsonism, Dopamine ukhululeka le ganglia basal eziningi enganele. esikhundleni sayo Kwenziwa ngokuthola levodopa, okuyinto eyandulela umzimba Dopamine.

Ingxenye enkulu kunazo zonke obalulekile walesi sakhi kwezicubu neuropathy iguqulwe ibe Dopamine, okungadingi iqhaza umphumela antiparkinsonian, ngenxa yokuthi ayikwazi ukungena ngokusebenzisa kusivimbeli gazi ebuchosheni, futhi iphinde ibheke iningi ukusabela ezingezinhle.

I kinetics kwezidakamizwa

Njengoba izazi njani izidakamizwa okukhulunywa ngakho, noma kunalokho, kinetic-inqubo yayo? Levodopa nge benserazide ugxile ogxile emathunjini amancane. Lapho ethola nemithi ku lokuhlushwa isiqongo kufinyelelwe emva kwemizuzu engaba ngu-65.

Kumele waphawula ikakhulukazi ukuthi i ukumuncwa lezi zinto incike intragastric pH izinkomba, kanye izinga excretion lokuqukethwe esiswini.

Lapho ethola levodopa ngokushesha ngemva kokudla lokuhlushwa yayo ephakeme kunazo zonke e-plasma-30% ngaphansi, nezinga ukumuncwa - 15% ephansi.

Izinto eziningi ezinkulu, lokhu izidakamizwa butholakala encane amathumbu, izinso, nesibindi. Nokho,% 1 nje ungena ubuchopho.

isigamu-ukuphila zomuthi kokubuyekezwa, isikhathi amahora amathathu.

Ngokungafani levodopa, ezifana ekwakhiweni ingxenye njengoba benserazide, akusho zingene Bbb. Le into is zanqwabelana wamaphaphu izicubu, izinso, isibindi kanye emathunjini amancane.

Lapho iqondiswa?

Izidakamizwa "Levodopa / benserazide" limelene Parkinsonistic. Ngakho-ke, kuhle ukuba amise:

• syndrome parkinsonian (syndrome ngaphandle kubangelwa imithi antipsychotic);
• Parkinson;
• ukubuyisa legs syndrome, kufaka phakathi nabantu ezingamahlalakhona ukwehluleka kwezinso abaku- isebenzisa umshini wezinso.

Uvala ukusetshenziswa

Kungakhathaliseki ukuthi kukhona Izimo kule izidakamizwa "Levodopa / benserazide-Teva" (izimpendulo ekhombisa ubuqiniso zabo, sicabanga ngezansi)? Lesi sidakamizwa akuvunyelwe ukuba amise:

• ukugula ngengqondo;
• hypersensitivity kuya ejenti izakhi;
• thuthuva sina ohlelweni endocrine, kanye izitsha inhliziyo;
• yezifo zezinso kanye isibindi, kodwa inqubekela phambili ukubuyisa legs syndrome ne kuhlanganiswe isivuno zelashwe;
• lactation;
• Ukuvalwa ukufiphala;
• isicelo parallel nonselective mao inhibitor;
• ukhulelwe;
• ngaphansi kweminyaka eyi-25;
• ubudala okuzala ubulili bubuhle, hhayi usebenzisa izindlela eziqinile zokuvimbela inzalo.

"Levodopa / benserazide": igama ezohwebo, indlela isicelo

Ukuthengwa ukucabangela nomuthi kungaba kunoma iyiphi ekhemisi. egameni lendawo yokuhweba noma izidakamizwa kuzwakala "Levodopa / benserazide-Teva".

Ngayiphi umthamo iqondiswa iziguli kubhekwe imithi? Ukwelashwa lezi izindlela uqale nge umthamo ongaphakeme, okuyinto liyakhula kancane kancane (ngayinye nesineke ngamunye).

Ngokusho ochwepheshe, kufanele ugweme ebulilini lokhu izidakamizwa. I nokushintsha kokudla nokufakwa lwemithi elandelayo kufanele kubhekwe njengendlela isincomo jikelele.

"Levodopa / benserazide", ezithathwe ngomlomo okungenani isigamu sehora ngaphambi noma emva kwemizuzu 65 emva kokudla.

Abantu ngaphambili ukuthatha lokhu kusho, ekuqaleni ukwelashwa ukutusa ukusetshenziswa 12.5 / 50 mg levodopa futhi benserazide kane ngosuku. Nge tolerability ezinhle umthamo luyanda esilinganayo njalo ngemva kwezinsuku ezintathu. Titration Okwalandela Kwenziwa imvamisa 1 ezinsukwini ezingama-30.

Ngokuvamile, nomphumela oqabulayo ngemva nokuphathwa izidakamizwa waphawula kakade lapho ithola 100 mg benserazide futhi mg 400 levodopa ngosuku.

Umthamo esiphezulu izidakamizwa ngelanga kuyinto 800/200 mg levodopa futhi benserazide ngokulandelana. Inani wathi ka nomuthi kufanele ihlukaniswe nge 4 noma ngaphezulu Ukweqiwa. Ngakho kufanele basakaza ukuze uhlinzeke isiguli nge umphumela elilungile zokwelapha.

With ukuthuthukiswa ukusabela ezingezinhle Kufanele andise umthamo noma ukuyeka, noma ukunciphisa ke.

I umthamo lwemithi zomuthi ezimweni emitholampilo ekhethekile

kufanele Ngithatha kanjani imithi "Levodopa / benserazide"? ochwepheshe lezivakashi ukubika ukuthi iziguli uhlangabezana ezinzima motor iyehla iyenyuka, umthamo wansuku zonke le imithi kufanele ihlukaniswe ngaphezu kuka-4 ukulaliswa esibhedlela.

Lapho esegugile, ukwandisa umthamo okufanele kwenzeke kancane.

Okuhlangenwe nakho kwabangane izidakamizwa ezinganeni kanye intsha kukhawulwe.

Ngo ukwehluleka hepatic futhi kwezinso nomuthi umthamo udinga ukulungiswa.

With ukuthuthukiswa iminyakazo ngokwawo, ikakhulu uma nisanda kamuva yokwelashwa, kutuswa ukunciphisa umthamo. Kuyefana nasendleleni imiphumela engathandeki we-CCC.

Izimpawu ukweqisa izidakamizwa

Reception "Levodopa / benserazide" ebulilini umuthi, omqondofana, ozokwethulwa ngezansi, kungabangela izimpawu ezifana isicanucanu, okungajwayelekile, ukunyakaza okungalindelekile bemvelo sokugembula, ukuqwasha, ukuhlanza, ukudideka. Kufanele kuphawulwe ukuthi kungase ukuthuthukiswa izimpawu ezinjalo zephuze ngenxa yokukhula kancane ukumuncwa zomuthi kusukela amathumbu.

Ukuze ekwelapheni izimo ezichazwe yokwelapha lingaze (ebekiwe izidakamizwa antiarrhythmic, analeptic zokuphefumula futhi neuroleptics), futhi kuqashwe njalo imisebenzi ebalulekile zomzimba.

ukuxhumana

Izidakamizwa "Levodopa / benserazide" baxhumana nezinye izidakamizwa kanje:

• Ukuthola trihexyphenidyl kunciphisa izinga kodwa hhayi kube sezingeni ukumuncwa levodopa.
• izidakamizwa Antihypertensive, opioids, neuroleptics kanye nemikhiqizo equkethe reserpine, zivimbela isenzo nomuthi kuchazwe.
• Isicelo nge antacids kunciphisa sezingeni ukumuncwa kusho ngaphansi ukucabangela 32%.
• Metoclopramide kwandisa izinga ukumuncwa levodopa.
• Ukwamukelwa pyridoxine kunciphisa umphumela imithi antiparkinsonian.
• Levodopa futhi benserazide kungenzeka ingasetshenziswa ngokuhlanganyela non-abakhethayo mao inhibitor.
• izidakamizwa Okubukwe potentiates isenzo sympathomimetic.
• Levodopa futhi benserazide nezinye izidakamizwa antiparkinsonian sithuthukisa imiphumela efiselekayo kanye engathandeki.

ulwazi oluthile

Ngaphambi kokuqala ukuthatha "Levodopa / benserazide" kufanele ahlolwe ngokugcwele wezokwelapha. Lokhu kungenxa yokuthi kukhona eziningi izifo lapho ukusetshenziswa kwaleli thuluzi kufanele kube ngokucophelela okukhulu:

• Ephambi kwezinduna engela evulekile yokwelapha glaucoma ungaqali kwaze kwaba ukuphulukiswa ephelele isiguli.
• Okunqatshelwe izidakamizwa evele khansela "halothane", njengoba kungase neqhaza ekuthuthukiseni ka neuroleptic syndrome ebulalayo ngesikhathi ukubulawa kwezinzwa okuvamile.

Kufanele kuphawulwe ukuthi ekuqaleni imithi yakhe ethatha kungenzeka imingcele bokuphila washintsha yisiguli. Kule ndaba, e imithi oyinikiwe liyadingeka ihlolwe ukuthi iyasebenza njalo ukuze kuqashwe ekusebenzeni kahle zonke izitho zangaphakathi.

Abantu abanesifo sikashukela kufanele kube izikhathi eziningana ngosuku ukuba uhlole igazi glucose.

Lokho okwakudingeka ukuze kukhokhwe izidakamizwa futhi analogue yayo / omqondofana

Ingakanani le izidakamizwa njengoba u- "L-Dopa / benserazide-Teva"? Intengo yaleli izidakamizwa incike inani amaphilisi iphakethe ngalinye. Ngokwejwayelekile ububanzi ruble 600-1250.

Yini kubhekwe ukuba esikhundleni izidakamizwa antiparkinsonian? analogue Its main futhi omqondofana zihlanganisa indlela esilandelayo: "Zimoks", "Duellin", "Isik," "Lac" "Dopar 275", "Carbidopa / Levodopa," "Sinemet", "Sindopa", "Tidomet", " Tremonorm ". Kumele ngokushesha waqaphela ukuthi izindaba okwakudingeka izici kwemithi kanye nezindlela usebenzisa le mithi ingase ihluke okungenhla. Ngakho-ke, ukuba esikhundleni saso kungene, "levodopa / benserazide-Teva" kufanele kuphela izincomo kadokotela.

Impendulo ukuphumelela izidakamizwa

Kuyinto imfihlo ukuthi isifo i-Parkinson isifo esiyingozi kakhulu. Ngaphezu kwalokho, kuyinselele engathí sina iziguli kanye nabathandekayo babo.

Ochwepheshe bezifo kanye abathengi ngesikhatsi ukwelashwa lokhu izidakamizwa kusithinta ngezindlela zonke iziguli. Ngezinye izikhathi ngisho ngaphansi kokuqondisa okuqinile udokotela nge reception eside amaphilisi kuyagcinwa ezigulini womuntu ukucasuka nangezikhathi ngobudlova. Futhi, ukusabela ohlangothini zenzeka njengoba ukusangana nesiyezi.

Ngokunciphisa Isikali kwezinye iziguli izimpawu elokugula ngengqondo zinyamalala, kuyilapho motor umsebenzi is hhayi kahle. Nokho, kwezinye iziguli, ngisho nangemva ukuqedwa ngokuphelele zomuthi zonke nokugula ngengqondo iqhubeka. Ngaphezu kwalokho, motor umsebenzi wabo liwohloka kakhulu.

Ngokuqondene nakho konke okungenhla, singaphetha kahle ukuthi reception izimali ezidingekayo ukuze uzilungiselele sokuthuthukiswa ezinzima emibi, njengoba kushiwo ngenhla.

Ngokusho imibiko wezazi, inqubo yokwelashwa sokulungiselela anti-Parkinsonistic okufanele kwenzeke kuphela ngaphansi kweso okuqinile udokotela. Lokhu kuzovumela ngisho umkhondo izinguquko ngomzuzu zisesimweni lesiguli esimiso senhliziyo nemithambo yegazi kanye psyche, futhi uma kunesidingo - asabele ngendlela esifike ngesikhathi.