Kuyini 5-alpha reductase? Ukwakhiwa - enzyme inhibitor

Zonke izinqubo emzimbeni kwenzeke iqhaza izinto bioactive, ikakhulukazi ama-enzyme. Libhekisela eqenjini izidakamizwa proteinaceous 5-alpha reductase. Ngeshwa, kwezinye izimo, ukungasebenzi kwenzeka enqubeni kwezici izinto asebenzayo okuholela ukungasebenzi wonke umzimba. Ngakho simele enzyme esebenzayo futhi lapho izimo, odokotela basebenzisa inhibitor 5-alpha-reductase? Yimiphi imiphumela kungenzeka yokwelapha? Ingabe kukhona Izimo? Izimpendulo zale mibuzo abafundi abaningi.

5-alpha reductase: kuyini?

Okokuqala, ake baqonde imisebenzi eyisisekelo ketshezi. 5-alpha reductase - kwakwakhe proteinaceous, i-enzyme okuyinto uhlanganyela inqubo steroidogenesis. Le into kuvusa ukuguqulwa kwe-testosterone (ubulili i-hormone wesilisa) ku dihydrotestosterone, esibonakala by nomphumela omkhulu. Ngaphezu kwalokho, ama-enzyme Akhuthaza ukwakheka kwe-allopregnanolone nezinye neurosteroids.

5-alpha reductase ikhiqizwa ikakhulukazi zokuzala uhlelo izitho, ikakhulu kwezicubu Prostatic kanye vesicles kwesidoda. Inani elincane enzyme nayo kukhiqizwa amangqamuzana esikhumba, izinwele follicle, futhi izingxenye ezithile zesimiso sezinzwa.

Kungani inhibitor?

Inhibitors 5-alpha-reductase - izidakamizwa ukuthi ukuvimba ukukhiqizwa enzyme futhi ezithinta inani lama-hormone ocansini besilisa emzimbeni. Namuhla, izidakamizwa ezinjalo zibizwa kabanzi. Ngokwesibonelo, avame engabelwe iziguli induna. Izidakamizwa kule usizo iqembu ukuvimbela Alopecia (impandla).

Kunezindawo eziningi ukusetshenziswa kwezidakamizwa ukuthi zivimbela ukukhiqizwa-enzyme ezifana 5-alpha reductase. Blocker ka DHT (dihydrotestosterone) asetshenziselwa ukwelapha hypertrophy Prostatic. imithi Proper kusiza ukuphungula wendlala nomthamo ukuvuvukala.

Ukuphumelela yokwelapha iye yaqinisekisa nezifundo esayensi eyenziwa endaweni yokucwaninga nge idumela emhlabeni wonke.

Inhibitors 5-alpha redukazy: zokwenziwa izidakamizwa

Kuze kube manje, ekwenzeni imithi kuleli qembu izithako ezimbili eziyinhloko asebenzayo:

1. Dutasteride kuyinto inhibitor abakhethayo futhi sisetshenziswa kabanzi ekwelapheni Hyperplasia ingozi ye-prostate. Umuthi ethandwa kakhulu kungenziwa ngokuthi "Avodart".

2. Finasteride - zokwenziwa izidakamizwa kubangela ukwehla izinga enzyme igazi hhayi kuphela, kodwa futhi ngqo nezicubu wendlala. Umthelela sithatha amahora angaba ngu-24. Ngezinye izikhathi isetshenziselwa ngisho ekwelapheni umdlavuza wendlala yabesilisa, nakuba yawo ngempumelelo 100% engakaze kungase kutholakale. Kukhethwa izidakamizwa, njengengxenye okukhona finasteride, nokunye okuningi: "Alfinal", "Urofin", "Finasta" "Proscar", "Zerlon", "Penester" kanye nabanye.

imithi herbal

izidakamizwa Zokwenziwa Yiqiniso, anganikeza nomphumela evelele. Kodwa izidakamizwa ngempela ngokuvamile asetshenziselwa plant-based - ezisithintayo umzimba ethambile futhi cishe ayinangozi. izindlela ezinjalo, ngenhlanhla nje kuphela esetshenziselwa yezifo wendlala. Asiza ekulweni nezinwele (Alopecia kuhlanganise nabesifazane) kanye induna.

Ukuze ekwelapheni wendlala hyperplastic izinqubo Palmetto izithelo kabanzi ukuthi abacebile fatty acid kanye phytosterols. Isoflavones - Elinye iqembu compounds okuyinto ifa izakhiwo antiandrogenic. Phela, it has izakhiwo ezifanayo futhi sembabazane. izitshalo Utshani kabanzi ukuze uqinise izinwele.

Zikhona yini imiphumela emibi zingenzeka?

Kumele kuthathwe ngokuqapha blocker-izidakamizwa 5-alpha-reductase, ikakhulukazi uma kuziwa zokwenziwa izindlela. Iqiniso lokuthi le mithi isinyathelo ngqo ibhalansi hormone isiguli.

ekuphathweni Ezingalapheki, iziguli eziningi izinguquko aphila ngayo ngokobulili. Ikakhulukazi, njengoba sekube nesicelo ukwephulwa of potency kwehle ubulili drive. ngocansi uvame ukuhambisana izinkinga: ukwakhiwa nesktoykoy, emfushane ubuhlobo bobulili, njll Imiphumela engemihle kuzomele sifake nokwehlisa ivolumu ejaculate ... Ngenxa nokuncipha inani neurosteroids ezigulini ekuthuthukiseni ukucindezeleka, nakuba lokhu side effect ezingavamile kakhulu.

Ukwelashwa ngempela kwenziwe ngaphansi kokuqondisa kukadokotela. Uma kuziwa amalungiselelo amakhambi, umzimba ngokushesha Ufika esetshenziswa, ngakho umphumela umuthi kancane kancane esiphansi. Ngakolunye uhlangothi, imithi engamakhambi okulula ephephile ezempilo.

Izimo ukusetshenziswa inhibitor

Akuzona zonke izimo, ungathatha imithi yokuvimbela umsebenzi-enzyme ebizwa ngokuthi "5-alpha reductase." Le mithi kungukuthi wabonisa iziguli khona iziyaluyalu acute ukuvuvukala kuhlanganise prostatitis.

Ngaphambi ezilandelwayo isikimu yokwelapha edingekayo ukuze kudlule ukuxilongwa okuphelele umzimba. Izinsolo of Oncology olwenziwa i biopsy we wendlala. Ukuba khona umdlavuza kuyinto contraindication ukuba ukusetshenziswa kwezidakamizwa. Futhi umuthi hhayi iqondiswa iziguli esikhathini nasezinkingeni ezilandela ngemva kokuhlinzwa ebukhoneni ukwehluleka kwezinso.