Incazelo yomkhiqizo "Vikeyra Pak". Izibuyekezo iphathwa, ikakhulukazi ukusetshenziswa Viekira Pak

ukulungiswa isizukulwane esisha-hepatitis C "Vikeyra Park" Izibuyekezo iphathwa ku omuhle kakhulu. Lokhu kungenxa ngokuyinhloko nekusebenta okusezingeni eliphezulu zomuthi.

Isenzo lesi sidakamizwa "Vikeyra Pak"

Isenzo zomuthi kusekelwe ezintathu zinhlobo zemithi elwa namagciwane. Lokhu "dasabuvir", "Ombitasvir" futhi ritonavir-booster "Paritaprevir". Njengoba izidakamizwa emhlabeni eyaziwa ngokuthi "Harvoni", "Vikeyra Pak" ukwelashwa okuphumelelayo kakhulu - isikhawu kusuka 97 kuya 99%. Umuthi ukusha kwesibindi kohlobo ingxenye yesine sivunyiwe e-United States. Phambi kwakhe, ukuhlolwa emitholampilo ngempumelelo bephumelele "Olizio" (igama ngesiRashiya - "Sovriad"), lohlanganisiwe "Harvoni" futhi "Sovaldi".

ulwazi olujwayelekile mayelana isizukulwane esisha ukulungiselela yezokwelapha

"Vikeyra Pak" (izimpendulo babephathwa baze baningi kakhulu, kusukela izidakamizwa yabhaliswa Russia kuphela ngoMeyi 2015) ekhishwe ngumkhiqizi Irish futhi zahlanganiswa e-United States. Umuthi okuthengiswa ngokusemthethweni eRussia, ungakwazi oda nganoma yisiphi ekhemisi. isithako we nomuthi:

• ritonavir;
• dasabuvir;
• paritaprevir;
• ombitasvir.

Libhekisela izidakamizwa elwa namagciwane ngqo (J05A). Lokhu nomuthi - isidakamizwa ezibizayo. Ngokwesibonelo, impatho amasonto 12 izobiza ruble ayizigidi 950 - lokhu kusho eziningi amaphakheji "Vikeyra Pak" (izindleko Petersburg). Izibuyekezo Umthengi phakathi ulwazi, uma ziqhathaniswa eyaziwa "Harvoni", intengo zazo eYurophu angaba yizinkulungwane 60 zamaRandi, umuthi Irish ayikatholakali ngokugcwele ukuze ithengwe. Kakhulu isabelomali inketho phakathi kwazo zonke buyisidakamizwa efanayo nalena ebizwa ngokuthi "Sunvepra" (intengo - ruble ayizigidi 400 ekwelapheni isikhathi esifanayo).

Imigomo nemibandela isitoreji

Incazelo egcwele ekulungisweni "Vikeyra Pack" ingafundwa ku iphakethe wezokwelapha. Yigcine kufanele ibe endaweni engafinyeleleki izingane ezingeni lokushisa hhayi ngaphezu kuka-25 degrees Celsius. Musa thatha izidakamizwa ngemuva kokuphela kwesikhathi ukusebenza - engu-2. Lonke ulwazi mayelana luhlobo "Vikeyra Pak": intengo, yokusetshenziswa, bangempela ezelashwayo nalezi izidakamizwa kufingqwe kulesi sihloko.

Ukusetshenziswa "Vikeyra Pak" futhi side effects

Ukwamukelwa izidakamizwa kokubuyekezwa for ekwelapheni isifo sokusha kwesibindi kohlobo C kumele kwenziwe ngesikhathi sakusihlwa, futhi ikhalori noma amafutha okuqukethwe imikhiqizo azinandaba. Ekuseni kumele uthathe amaphilisi amabili paritaprevira / ritonavir / ombitasvira, uhlanganise okukodwa ithebhulethi dasabuvir. Lesi sakamuva kumele idliwe kusihlwa. Ezinye iziguli kudokotela sinquma indlela "Vikeyra Pack" ngokuhlanganyela "Ribavirin". Uma oyikhethile nje ukwelashwa okunjalo, "Vikeyra Pak" owamukelwa ezweni inani amaphilisi eziyisithupha ngosuku:

• ekuseni ngosuku - eyodwa emnyama ne-tablet ezimbili ukukhanya;
• kusihlwa - ngokumnyama;
• kabili ngosuku "ribavirin" endaweni umthamo mg 500.

Ukusetshenziswa "Vikeyra Pak" (izibuyekezo phakathi amazwana kanye nezifundiswa wazibonela) kufanele ngempela wavumelana kudokotela. Uma isiguli uhlushwa co-ukutheleleka nge-HIV, le mishanguzo Isikali kuyafana, plus, ngempela - ngezikhathi zokudla. On the isembozo kungukuthi efakwe ohlwini ezinzima side effects ekuthatheni lesi sidakamizwa. Okuvame kakhulu ngeziphambeko kungenzeka, ngokuvumelana ukubuyekezwa kanye imiyalelo - kuyinto:

• asthenia;
• ukuhlinza ukusabela, kuhlanganise pruritus;
• ukukhathala;
• nokungalali;
• isicanucanu.

Icebo imithi oyinikiwe

"Vikeyra Pak" isikimu ukwelashwa kuhlanganisa inhlanganisela yemithi emithathu, yinkampani "EbbVay" plus pharmacokinetic sithuthukisi uhlobo ngokuthi "Ritonavir" ngokuba izidakamizwa. izidakamizwa lwemithi ekwelapheni isifo sokusha kwesibindi kohlobo C inikezwa ekwelapheni HCV (genotype 1a) lihambisana "Ribavirin". Inkambo kumele okungenani ibe full amasonto 12. Ukuze genotype 1b aphathwe ngendlela efanayo, kodwa ngaphandle iinthombe izidakamizwa yokugcina. Ngaphezu kwalokho, "Vikeyra Pack" (izimpendulo babephathwa ngaphansi kohlelo ubukeka ezingaphezu kuka umxhwele) senzelwe nokwelashwa kweziguli isifo sokusha inzuzo. Course - amasonto 24 "Ribavirin" ngoba genotype 1a, kwezinye izimo - amasonto 12.

Ngasekelwa impendulo virological iziguli (genotype 1a) nge ukungabi khona isifo sokusha yafinyelelwa ngo-97% amacala, kuyilapho 1b - 100% kumakwe ukuthi ukwelashwa owawuse hlobo. Ihlawulelwa isibindi sibe sesomile SVR ifinyelele ezingeni 95% (Ukwelashwa eyathatha amasonto 24) ngokuba 1a genotype, kwezinye izimo (1b) uphawu esondela amaphesenti ayikhulu.

Izimo

Ukulungiselela "Vikeyra Pak" (izilinganiso iphathwa qinisekisa ke) has, njenganoma yiluphi izidakamizwa, eziningi Izimo. Lezi zihlanganisa lokhu okulandelayo:

• kokusebenza kwesibindi decompensated;
• hypersensitivity kuya ritonavir;
• hemoglobinopathies;
• kanyekanye wajaha "DDI ngezibalo" Ukwelapha;
• ukhulelwe;
• ethola inhibitor isinyathelo esiqatha;
• ethola inducers eqinile.

Kufanele kuqashelwe ukuthi ukusetshenziswa le imithi izingane abangazange sebethole yobudala, akuvunyelwe nakancane. Ngaphezu kwalokho, lactating ukwelashwa abesifazane is hhayi Kunconywa ngenxa yokuntuleka ulwazi olungenaphutha ngemithi kwema- izinto asebenzayo "Vikeyra Pak" e ubisi lwebele womuntu. Qiniseka ukuthi ufuna ukumisa ibele.

Isexwayiso ekusebenziseni

I-US IHhovisi Quality Control kwemithi libike ukuthi "Vikeyra Pak" futhi analogue, asetshenziselwa ukwelapha isifo sokusha kwesibindi kohlobo C kungaholela ukulimala kwesibindi engelapheki. Lokhu kuyiqiniso ikakhulukazi abantu abakhubazekile emsebenzini isitho esibalulekile. Ngenxa yalesi sizathu, umenzi ukwenze izichibiyelo ezithile yokusetshenziswa zomuthi.

Uma izaziso nesineke ukuthi ukudlula yokwelapha ivela kaningi ukukhathala nokutubeka, isiyezi, nauseous, futhi ngokuvamile kukhona ukuhlanza, kanye aqale ukuze ujike isikhumba ophuzi, kufanele nakanjani bafune usizo lobuchwepheshe ngenxa yokuthi kukhona amathuba ukulimala kwesibindi. Misa kokuthatha lesi imithi ngaphandle kwemvume yodokotela wakho kunoma yiliphi icala akunakwenzeka, njengoba lokhu kungabangela ukumelana umzimba kwezinye izidakamizwa, ukulwa kwesibindi. Udokotela esibhedlela kufanele kube isikhathi sokugubha nesineke ukuqeda izimpawu umsebenzi sesibindi. Lezi zihlanganisa:

• opha varices ngomphimbo;
• ascites;
• anda bilirubin ezingeni;
• encephalopathy.

ukuthaka imithi ngendlela zakhe ezinjengethi, "Vikeyra Pak" athuthukisa ukunciphisa okuphawulekayo inani hepatitis C virus emzimbeni womuntu, ngaphezu, angase kancane ukuqhubeka kwesifo.

Kadokotela of umuthi omusha i-hepatitis C

Izakhiwo Viekira Pak ukwelashwa zihlanganisa inhlanganisela ngemithamo amaningi kwezidakamizwa ezithile ukuthi sisetshenziswa ndawonye "Ribavirin" noma cha. Umuthi sivunyiwe for ekwelapheni iziguli isibindi sibe sesomile futhi kwesibindi kohlobo C. Ngaphambi kokuqala ukusebenzisa izidakamizwa umbuzo, kubalulekile ukwazisa udokotela ngalokhu okulandelayo:

• khona yokutheleleka nge-HIV;
• nezinye isifo sesibindi, ngaphezu hepatitis C;
• ukusetshenziswa izinto zokuvimbela inzalo, kuhlanganise ethinyl estradiol.

Kuyaphawuleka ukuthi ezimweni eziningi imiphumela emibi izidakamizwa njengokubatshwa kwezindlebe zabo, futhi ukuluma kwesikhumba, nokungalali nokunxanela ukuba ahlanze. Ngokwe-ukunakekelwa 2015 bezempilo linqume kwemithi okuthiwa "Vikeyra Pack" abantu abangaphezu kuka-11 000.

Yini bonke abantu kufanele bazi isiguli welashelwa?

Uma isiguli asitholayo inkambo 12 noma 24 ngosuku-yokwelashwa, akunakwenzeka ukuyimisa ngaphandle kwemvume kadokotela. Lokhu kungaholela ukuvela ukumelana nezinye izidakamizwa ontanga. Kubalulekile nokukhumbula ukuthi uma isiguli isihambile esiteji of isifo sesibindi, i- "Vikeyra Pack" kungabangela umonakalo isitho abucayi, kuhlanganisa yokwehluleka kwesibindi. Qiniseka ukufuna usizo esibhedlela, uma kubonakala Ukuphinda njalo izimpawu ezifana ukuhlanza, yellowing we sclera, okungazelelwe ukulahlekelwa simbe ukudla, sezinyawo enombala okhanyayo.

Ngaphambi kokuqala ukwelashwa, kutuswa ukuba ufunde imiyalelo. Noma yimiphi imibuzo okufanele kuxoxwe nodokotela wakho. Awukwazi ukufihla noma yiluphi ulwazi mayelana nesimo se-ezempilo, kuhlanganise abasafufusa imiphumela engemihle ejenti 'Vikeyra Pak ".

Kuhlola nokuphepha

ukulungiselela Ukuphepha "Vikeyra Pack" nohlolwe ngesisekelo idatha lesibili kanye Isigaba sesithathu zokwelapha cishe 3,000 iziguli welashelwa lihambisana "Ribavirin" futhi ngaphandle. Futhi usebenzisa idatha ku iziguli isibindi sibe sesomile. ukusabela ezingezinhle ekusetshenzisweni babonakala e-20% amacala. Izimpawu ezivame kakhulu - kuyinto isicanucanu nokukhathala okukhulu. Imise ukwelashwa ngenxa yemiphumela emibi% 1.15 nje. Baphindela inkambo yabo ngemva kokuphazamiseka yokwelapha - 1.4%. Ngenxa abantu basabele ngendlela embi umzimba ukuba umthamo izidakamizwa lancipha, "Ribavirin" 8% eziguli.

Umehluko impendulo umzimba ukuze umuthi in iziguli futhi ngaphandle isibindi sibe sesomile babonakala. Ocwaningweni emitholampilo Thina sihileleke iziguli ababelandela 'Vikeyra Pak "futhi ngaphandle" ribavirin ". Wawusho kuphela yokusabela kuya izidakamizwa, kuleli cala - ukuvela ukulunywa esikhumbeni. ukwelashwa wayekwa yalesisizathu% 0.4 kuphela, ikhefu yokwelapha ukwenze mayelana 0.6% eziguli. Kuhlola ukuphepha izidakamizwa "Vikeyra Park" owaba ngo nemingcele eziningana (futhi ngaphandle ngokoma kwesibindi, ne ukwengeza "Ribavirin" Lutho neze) futhi phakathi ukwelashwa, okungukuthi, amaviki angu-12 no-24.

izindleko elinganiselwayo "Vikeyra Pak" eRussia nakwamanye amazwe

E-United States of America "Vikeyra Pack" kubiza cishe 84.000 zamaRandi (kuhlanganise sezinsuku ezingu-12 Inkambo yokwelashwa), inqubomgomo yokukhokhisa Russian Federation, njengakwamanye amazwe amaningi aseYurophu, yehluke.

Kumawebhusayithi ahlukahlukene kuyi-Internet ungabona izindleko ezihlukahlukene imithi Irish. Ukuze ezikhungweni zokwelapha eRussia izindleko "ejenti Vikeyra Pak 'kuyinto ruble ecishe ibe yizinkulungwane 300 inyanga eyodwa yokwelashwa. Phakathi neviki-12 kuyodingeka bakhokhe ruble mayelana 850-900. Ngakho, labo abelwa imishanguzo amasonto 24, kudingeka ukuthenga imithi ukusha kwesibindi kohlobo C akuyona ruble ngaphansi kuka 1.5 million.