Amlodipine Umhlahlandlela

Medicine "Amlodipine" MHLAWUMBE ujwayelene kwabaningi lokuqala isandla. Ngokuyinhloko, lokhu izidakamizwa ezinqunyiwe iziguli angina. Ake sicabangele lesi sidakamizwa "Amlodipine" kabani imiyalelo aqukethe ulwazi okulandelayo.

Ukwakheka. Omunye ithebhulethi (5 mg) equkethwe esebenzayo izidakamizwa amlodipine besylate. Njengoba excipients wasebenzisa i-lactose, amazambane isitashi, collidone, microcrystalline cellulose, magnesium stearate.

incazelo Jikelele. "Amlodipine" Tablets omhlophe noma cishe white ne ngokuhlanganyela amabili emaceleni. Ngezikhathi ezithile ukukhanya kungenzeka marbling samanje.

Pharmacodynamics. Dihydropyridine esuselwe - amabhlogo calcium iziteshi "kancane" lesibili isizukulwane has gipotezivnoe nemiphumela antianginal. Okuhambisana yokwamukela dihydropyridine futhi uyazifeza ukuvinjelwa iziteshi calcium, ngaleyo ndlela kuncishiswe ukudlula transmembrane-calcium ion esitokisini (ngokwezinga elikhulu ezicutshini bushelelezi isitsha kwezindonga e myocytes inhliziyo). umphumela Antianginal kubangelwa ukunwetshwa imithambo kanye arteriole elise azungeze: angina umenshaetsnizhaet kobukhulu ischemia esivimba amanzi, Umthambo neuropathy yandisa, ngaleyo ndlela sinciphise Imininingwane semithambo ukumelana neuropathy, ngaphezu kusiza ukunciphisa Layisha ku inhliziyo, kunciphisa isidingo inhliziyo oxygen. In iziguli angina, umthamo owodwa nsuku kwandisa isikhathi run fiznagruzki, kubamba ukuthuthukiswa ischemia futhi angina, plus konke kunciphisa kaningi sokuhlaselwa angina futhi isidingo nitroglycerin. Ngakho, iziguli ezinemishini angina idinga "Amlodipine" Umhlahlandlela lo ubufakazi.

Pharmacokinetics. Ngemva kokuphathwa ngomlomo izidakamizwa kancane matasa kusukela ipheshana emathunjini. Ingabe Ohulumeni Banalo Lonke bioavailability silinganiselwa ku-64%, i-kanzulu kakhulu kule serum igazi ngemuva kwamahora 6-9. ibhalansi Esitebeleni egazini siyenzeka ngosuku 7th. Ukudla akuphazamisi ukumuncwa amlodipine. Ezigulini esezikhulile (abaneminyaka engaphezu kuka-65) le excretion zomuthi is kancane kuqhathaniswa abasha, kodwa lo mehluko akuyona isifo abalulekile.

"Amlodipine" imfundo equkethe lonke ulwazi olufanele has izimpawu ezilandelayo ukuze isicelo: i unomfutho wegazi ophakeme (lihambisana namanye noma ngendlela efanayo monotherapy), angina exertional, angina vasospastic (angina Prinzmetal sika).

Izimo.

- sensitivity high ukuze isithako esebenzayo nezinye nemikhiqizo dihydropyridine;

- hypotension ngefomu ezinzima;

- cardiogenic ukushaqeka, nciphisa;

- angina engazinzile (ngaphandle - angina Prinzmetal);

- lactation kanye nokukhulelwa;

- I-abaneminyaka engaphansi kwengu-18 zokuphepha kanye nomphumela ungazange sezisunguliwe.

Umthamo kanye indlela isicelo. Thatha "Amlodipine" imfundo uhlinzeka kanje: ngaphakathi, umthamo ubuncane 5 mg, esiphezulu - 10 mg 1 isikhathi ngosuku. Lapho umfutho wegazi ophakeme umthamo sesondlo kungaba 5 mg ngosuku. Lapho imivimbo ezithathiwe kanye 5-10 mg ngosuku. iziguli Izacile, kanye neziguli ongaphakeme neziguli nge isibindi kahle ekusebenzeni iqondiswa 2.5 mg.

imiyalelo Special. Phakathi Inkambo yokwelashwa nge "Amlodipine" kufanele ulandele isisindo kanye ukusetshenziswa kwezinto ezifana sodium, ngezinye izikhathi okudingeka uhlobo olukhethekile lokudla. Kubalulekile ukulandela inhlanzeko yomlomo namazinyo, vakashela udokotela wamazinyo njalo (ukugwema ubuhlungu nokopha izinsini). Ngokwandisa umthamo kwasebekhulile kudinga aqashelwe ngokucophelela. Umthelela izidakamizwa ekhonweni ukushayela imoto akukho idatha. Nokho, kufanele sikhumbule ukuthi abanye abantu-ke kungabangela nesiyezi kancane futhi ukozela.