Amaphilisi e-Paglyuferal: imiyalo yokusetshenziswa, i-analogues nokubuyekezwa

Abantu abahlushwa isifo sokuphuza kufanele bahlale bethatha izidakamizwa zokulwa nezifo. Basiza ukuvimbela ukuthuthukiswa kokugubha, futhi kuthuthukise inhlalakahle jikelele nesimo sesiguli.

Yiziphi ngempela izidakamizwa okufanele zisetshenziswe iziguli ezinesithuthwane kufanele ziqokelwe kuphela udokotela onolwazi. Izidakamizwa eziphumelela kakhulu nezithandwayo ze-anticonvulsant zihlanganisa umuthi "Paglyuferal". Imiyalo yokusebenzisa le mithi izochazwa ngezansi. Futhi uzothola ngesimo lapho lesi sidakamizwa siqhubeka sithengiswa khona, kungakhathaliseki ukuthi singayinika izingane, yiziphi izinto ezihlala nazo njalo njalo.

Incazelo, ukupakisha, ukwakheka kanye nefomu

Ukulungiselela "Paglyuferal", imfundo yokusetshenziswa kwayo iqukethe amaphakethe wekhadibhodi, iyaqhubeka ithengiswa ngendlela yamathebulethi amhlophe anesici futhi engozini.

Lo mkhiqizo uqukethe izithako ezisebenzayo ezifana ne-phenobarbital, i- caffeine sodium benzoate, i- bromide, i-calcium gluconate ne- papaverine hydrochloride. Ngokuqondene nezinto ezisizayo, zifaka isitashi sezambane kanye ne-calcium stearate.

Ungathenga le mithi kumakhanti okugqaja namaphakethe wephepha elinzima, ngokulandelana.

Kumele kuqashelwe ngokushesha ukuthi emashalofini ama-pharmacy onjalo umuthi ungatholakala ngamagama alandelayo: "Paglyuferal-1", "Paglyuferal-2" ne "Paglyuferal-3". Imfundo yokusetshenziswa ikwazisa ukuthi umehluko phakathi kwalezi zindlela kuwubukhulu bokulinganisa kwe-phenobarbital (25, 35 no-50 mg ngokulandelana).

I-Pharmacology

Uyini umuthi "Paglyuferal"? Imiyalo yokusetshenziswa (amathebulethi kufanele anqunywe kuphela ngumchwepheshe onolwazi) uthi leli yi-agent antiepileptic ehlangene.

Ngokusho kochwepheshe, phenobarbital iyakwazi ukuxhumana nendawo ethi "barbiturate" ye-benzodiazepine-GABA-receptor complex. Ngenxa yalokhu, lo muthi ukwandisa ukuzwela kwe-GABA-receptors ku-GABA, futhi kuvula imigudu ye-neuronal yokuthutha ama-chloride ions, okwenza kube nokwanda kokungenwa kwamaseli.

Futhi, i-phenobarbital inciphisa ukusabalala kwemiqondo ye-nerve kanye ne-excitability ye-neurons ekugxilweni kwe-epileptogenic. Ubonisa ukuphikisana ngokuphathelene nenani labaxhumanisi abathandekayo.

Yiziphi ezinye izinto ezifakwe kuphilisi "Paglyuferal"? Imfundo ithi iyakwazi ukuvimbela izindawo ezinomqondo we-cortex ye-cerebral, ukunciphisa ukusebenza komsebenzi, ukuvimbela imisebenzi ye-cerebral, kufaka phakathi isikhungo sokuphefumula. Futhi lo muthi unciphisa ithoni ye-musculature ye-tract digestive, ine-anticonvulsant, sedative, hypnotic kanye ne-spasmolytic effect.

Izici zomuthi

Ngaphezu kwe-phenobarbital, ukwakheka kwe-ejenti okucatshangwayo kuhlanganisa nezinye izingxenye ezisebenzayo.

Iyini indima ye-caffeine ekulungiseleleni "i-Paglyuferal"? Imiyalo yokusetshenziswa ibonisa ukuthi le nto ingakwazi ukwandisa ukuqhuma komgogodla we-reflex, ukujabulisa ama-vasomotor nezikhungo zokuphefumula, kuvuselele izinqubo zokuqubuzana kwezicubu ezinhlotsheni nezitho, kuhlanganise nesimiso nesimiso sezinzwa zomphakathi.

I-Papaverine hydrochloride i-antispasmodic. Inomphumela omubi kakhulu. Lesi sigaba esidakamizwa sinciphisa ithoni futhi sivuselela imisipha ebushelelezi yemithwalo yegazi nezitho zangaphakathi.

I-gluconate ye-calcium iyakwazi ukugcwalisa ukungabi nalutho kwe-i-calcium ions, okudingeka kakhulu ukudluliselwa kwemizwa ye-nerve.

Ngokuqondene ne-bromizoval, inomphumela omuhle wokudambisa nokudambisa.

Izakhiwo ze-kinetic

Ingabe umuthi "i-Paglyuferal-1" ungene emgodleni wegazi? Imiyalo yokusetshenziswa ikhombisa ukuthi ingxenye ngayinye esebenzayo yalesi sidakamizwa inezici zayo zokwazisa.

• I-Phenobarbital ibanjwe ngokuphelele, kodwa kancane (kungakapheli amahora angu-1-2). I-metabolism yayo yenziwa esibindi. Ingxenye yokuphila yalesi sigaba yizinsuku ezingu-2-5. Ikhishwe emzimbeni yizinso.
• I-caffeine isondelene kahle kahle emathunjini. Ukuhlushwa okukhulu kwalokhu kutholakala ngemuva kokuphela kwemizuzu engu-50-75. I-metabolized in the isibindi, futhi iyadalulwa ngokusebenzisa izinso.
• I-bioavailability isilinganiso ye-papaverine ingu-54%. With amaprotheni e-plasma, ibophezela ku-90%. I-metabolism yenzeka esibindi, futhi idonswa izinso.
• Cishe 1/5 yomthamo we-calcium gluconate etholakalayo igxila emathunjini amancane. Cishe u-20% walo mzimba uphuthunyiswe ngokusebenzisa izinso, kanti konke okunye - kanye nesikhumba.

Izinkomba

Iziphi izifo ezibekiwe ngokuthi imithi "Paglyuferal-2"? Imfundo yokusetshenziswa ithi lesi sidakamizwa senzelwe ukwelashwa kwesithuthwane.

Ukungafani

Yiziphi izinkampani ezichasayo zezidakamizwa "Paglyuferal"? Imiyalo yokusetshenziswa (izangane leli thuluzi ayimisiwe) libika lezi ezivinjelwe:

• I-Hyperkinesis;
• Kubonakaliswe ukungakwazi ukusebenza kwe-hepatic ne-renal;
• I-Myasthenia gravis;
• Ukuxhomeka kwezidakamizwa;
• Ukucindezeleka;
• I-anemia ekhululekile;
• Hyperthyroidism;
• I-Porphyria;
• Ukudakwa ngokweqile;
• Isifo sikashukela sikhona;
• Ukukhulelwa;
• Ukusebenza kwama-glands adrenal ;
• Isikhathi sokubamba iqhaza;
• Izifo ezithintekayo ze-Bronchial;
• Hypersensitivity.

I-anti-epileptic agent ezibhebheni inqunyelwe izingane ezineminyaka emithathu ubudala. Ngokuqapha, kunconywa kubantu abanesimo esibuthakathaka (jikelele).

Ukulungiselela "Paglyuferal": imiyalelo yokusetshenziswa

Imithi ebuzwayo ithathwe ngomlomo emva kokungenisa. Isilinganiso sawo sincike ekufakeni indlela yokukhululwa.

Amalungiselelo "Paglyuferal-1" no- "Paglyuferal-2" athathwa kabili ngosuku ":

• Eminyakeni engu-3-4 - ithebhulethi engu-1;
• Eminyakeni emihlanu kuya eyisithupha amaphilisi -1.5;
• Eminyakeni eyisikhombisa nesishiyagalolunye - izingcezu ezimbili;
• Eminyakeni eyishumi neshumi-3 no-2.5 ama-pcs. Ngokulandelanayo;
• Kusukela eminyakeni eyishumi nane - ama-4 ama-PC.

Isidakamizwa "Paglyuferal-3" sithathwa kabili ngosuku:

• Eminyakeni eyisikhombisa kuya kwengu-9 - ithebhulethi 1 kabili ngosuku;
• Eminyakeni eyishumi neshumi nane - amaphilisi angu-1,5;
• Kusukela eminyakeni eyishumi nane - 2 ama-pcs.

Imiphumela emibi

Ukuthatha le mithi kungabangela:

• Ama-hallucinations, ubuthakathaka, isiyezi, i-nystagmus, i-ataxia, i-dysarthria, ukuphazamiseka kokulala, ukuphendula okuphazamisayo;
• Ukuqothulwa, isicanucanu, isifo sohudo, ukwanda komsebenzi we-transaminase ye-hepatic, ukuhlanza;
• I-Thrombocytopenia, i-agranulocytosis, i-anemia ye-megaloblastic;
• I-Tachycardia, izinguquko e-blood pressure, extrasystole, arrhythmia, AV ukuvinjelwa;
• Ukusabela okuvamile kwe-synergy, ukuxhomeka kwezidakamizwa (okuvunyelwe isikhathi eside).

Izimpawu zokudlula ngokweqile

Amanani aphezulu wezidakamizwa angabangela ukwanda kwezimpikiswano ezimbi. Ukuqeda izimpawu ezinjalo kusebenza:

• Ukugcoba nge-gastric;
• Ukwelashwa okuyisimangaliso;
• Ukwamukelwa kwekhabhoni esebenze.

Ukusebenzisana kwezidakamizwa

Ukwelapha nge-valproate ne "Phenytoin" kwandisa izinga le-serum phenobarbital.

"I-Paglyuferal" iyakwazi ukuvimbela umphumela wemithi yokukhulelwa ngomlomo nama-salicylates.

Uma kuhlangene ne-"Reserpine", umphumela we-phenobarbital ukwanda, futhi uma kuhlangene ne "Amitriptyline", "Diazepam", "Chlordiazepoxide", "Nialamide" ne-"Acetazolamide" - yehla.

Isidakamizwa esithi "Paglyuferal" sinciphisa izinga le-GCS egazini, kanye nama-anticoagulants angacacile, "i-Doxycycline", "i-Griseofulvin", i-estrogens namanye ama-agent aphikisiwe esibindi.

Lesi sidakamizwa sivimbela umphumela we-sulfonamides, umsebenzi we-antibacterial kanye nemiphumela ye-antitifungal ka-Griseofulvin. Ngaphezu kwalokho, kungabangela imiphumela ye-neuroleptics, i-ethanol, i-analgesics yama-narcotic, i-muscle relaxants, i-hypnotics ne-sedatives.

Ukubuyekeza nama-Analogues

Ngokusho kochwepheshe, izidakamizwa ezibuzwayo azikho izifanekiselo, ezifana nokubunjwa. Ngakho-ke, ukuze uyishintshe, isiguli kufanele sixoxe nodokotela onolwazi.

Abathengi bathi ngeke bakwazi ukuthenga le mithi ngaphandle kwemithi yezokwelapha, nakuba kungabizi kakhulu.

Abantu abaye bathatha isimiso se-antiepileptic bayiqaphele imiphumela yabo emihle. Kodwa-ke, abanye babo basakhononda ngokuthi kwenzeke inani elikhulu lemiphumela emibi.