Amalungiselelo digitalis: izinkomba nemiphumela yezifo zenhliziyo

Digitalis - uhlobo lwe ezimila eziqhakazayo, ezisetshenziswa njengoba ikhambi for iziyaluyalu zenhliziyo.

Mayelana kardiotropnyh izakhiwo le mbali Sekuyisikhathi eside kwaziwa. Engxenyeni yokuqala yekhulu XVIII, ke eqala ukukhuluphala eRussia emasimini njengokwenza komthaki, futhi kusukela ngo-1775, lapho yashicilelwa imisebenzi Uayteringa wezempilo waseBrithani, digitalis amalungiselelo kwenzeka kakhulu umkhuba ekwelapheni izifo inhliziyo.

Izimfanelo Botanical digitalis

Rhode foxglove (digitalis) - Izimbali izitshalo zisetshenziswa umndeni plantaginaceae ne inflorescences enkulu thimbles efana izimbali namaqabunga obucayi esishwabene. Bloom phakathi no-ehlobo (ekupheleni June-July), izithelo - amabhokisi alo Iqanda emise ne ezincane imbewu ensundu. naperstyanok Ubude echazwe 36 izinhlobo ezisetshenziswa ngezinhloso zokwelapha 5 kuphela: lanata digitalis (umthombo oyinhloko izinto zokusetshenziswa), onsomi, ciliated, futhi grandiflora ibuthuntu.

Ekuqaleni lanata izidakamizwa digitalis kwaba sicashunwa amaqabunga konyaka wokuqala nowesibili. Okwamanje, imithi digitalis glycosides eyatholakala kusukela izingxenye sendawo izitshalo, mowed ngaphambi zom.

Zonke foxglove ezinesihlungu, okubonisa ukuthi inani elikhulu izinto eziphila abakhuthele futhi kudinga handling ngokucophelela.

izingxenye Chemical futhi isicelo foxglove

Imithi digitalis zihlanganisa izithako zako ezisemqoka asebenzayo - glycosides inhliziyo: digitoxin, gitoksin, digoxin, atsetildigoksin nabanye abaningi, kanye acid organic, saponins, flavonoid.

izingxenye Iningi asebenzayo sibe hydrolytic imvelaphi yesibili, isb etholwe cleavage enzymatic zishintshe zemvelo glycosides.

digitalis izidakamizwa esetshenziswa ukwelapha izifo eziningi inhliziyo, ikakhulu ezihlobene ukungakhuli izitsha inhliziyo negazi:

1. ukuhluleka Inhliziyo kanye izilonda organic ezihlukahlukene izakhiwo inhliziyo (kuhlanganise njengoba isilinganiso izifo).
2. Izifo valve inhliziyo okuholela decompensation.
3. fibrillation atrial.
4. Ukuvuvukala futhi angakwazi imisipha yenhliziyo.
5. Paroxysmal tachycardia kwabesifazane abakhulelwe.
6. Ukulungiselela ukuhlinzwa inhliziyo.

Lapho ukwephulwa inhliziyo conduction uhlelo (block) kanye bradycardia digitalis glycosides kungukuthi inikezwa.

Kanjani glycosides izidakamizwa digitalis

Behlukene utshani digitalis glycosides umphumela ethize ku imisipha yenhliziyo. Ngo ukumelwa inhliziyo, umphumela digitalis isicelo simiswe ngalendlela lelandzelako:

• ehle kwenhliziyo;
• anda esivimba amanzi contractile amandla;
• ayewukela kwesikhathi sokuzijabulisa asibashiyi wenhliziyo (diastole).

amalungiselelo digitalis ziye zasetshenziswa ekwelapheni ukwehluleka kwegazi, lapho inhliziyo eyikho wehluleka ukubhekana ekunyusweni imithambo yegazi, okuyinto nzima edema neziyaluyalu trophic ngempumelelo. Kulokhu, izidakamizwa glycosidic kulindeleke ukuba:

• anda okukhipha inhliziyo (inani legazi ephuma ventricles ukunciphisa ngayinye);
• Ukuthulula abaphumelelayo ventricles ngesikhathi systole;
• Ukwehla igazi ivolumu afundwa ezitsheni, futhi ngenxa yalokho, ekunciphiseni ukuvuvukala;
• ukuzinza of kwenhliziyo tachycardia;
• ukusheshisa ukugeleza kwegazi embhedeni semithambo;
• anda ithoni semithambo, okuyinto kuhambisana ukwenyuka okuncane nje umfutho wegazi.

Digitalis ubuthi angase avuse engathandeki side effects ukuphazamiseka pheshana emathunjini, isimiso sezinzwa, kwenhliziyo izinguquko. Ukusetshenziswa okungagunyaziwe mithi akwamukelekile, eziyalezweni ukwelashwa udokotela ukhetha kuphela inikezwe nesineke ngabanye.

Izidakamizwa kusukela foxglove mammoth

"Tselanid" - glycoside inhliziyo isinyathelo ngokushesha ikhiqizwa ngesimo amaphilisi kanye isixazululo umjovo emthanjeni. The main izinkomba - ukwehluleka kwegazi, tachycardia, fibrillation atrial.

"Digoxin" libhekene ukwanda contractility esivimba amanzi, akwephuli kwegazi yenhliziyo bese kunciphisa ukuvuvukala ngenxa yemiphumela isisu. Ngemithambo yegazi futhi ngomlomo. It is kuboniswe ezibangela ezinzima kwegazi futhi ngesikhathi kuhlaselwa ka tachycardia paroxysmal esimweni esiphuthumayo.

umphumela zokwelapha ifinyelela esiphezulu emva kwesikhathi lapho ketshezi asebenzayo emzimbeni ifinyelele lokuhlushwa ezithile. Kukhona nomphumela ezuziwe (inqwaba) ngenxa yokuthi digitalis amalungiselelo avele kancane.