"Alfacalcidol": yokusetshenziswa, ifomu ukukhululwa, izibuyekezo, izithombe, umthamo, analogs

Ukungabi vitamin D3 kubangele izinkinga ezingathi sína. Ezinganeni lokhu kusilela igcwele ukuthuthukiswa yamathambo, ngenkathi abadala ukuze kube kuhle ukuntula imbangela kwamathambo nezinye izinkinga ezifanayo.

Imakethe yesimanje of Medicine inikeza amakhasimende ayo ezahlukene kwemithi ukuqeda ukuntula zonke saleli vithamini. Omunye imithi enjalo kuyinto "Alfacalcidol." Yokusetshenziswa ephawula njengethuba izindlela ezisebenzayo kujwayeleke ibhalansi Vitamin-amaminerali.

pharmacodynamics

Lokhu nomuthi kuyinto Vitamin D3 ifomu asebenzayo. Ukulawulwa exchange of compounds amaminerali abalulekile, njengoku- phosphorus ne-calcium, futhi isici esibalulekile saleso lesi sidakamizwa "Alfacalcidol." Ukusebenzisa izidakamizwa iphumelela ukuvuselela ithambo kumiswa. Ngo ukuzibandakanya yayo ngqo lenyuka ukumuncwa kwe-calcium ne phosphorus emathunjini nezinso. Ngaphezu kwalokho, lokhu izidakamizwa kwandisa ithambo amaminerali ukuminyana futhi ngesikhathi esifanayo kunciphisa izinga okuqukethwe kule PTH igazi. Ngenxa yalokho, "Alfacalcidol" has antirahitichnoe nomthelela futhi kusiza ukunciphisa inani waphuka.

Uma umuthi ukuba bakhethe izifundo zokwenezela ke, ngenxa yethonya lakhe ngcono ukubambisana, encishisiwe amathambo imisipha ubuhlungu (okuyizinto umphumela lokwephulwa calcium-phosphorus umzimba).

Kwezinye izimo, walungisiswa ukusetshenziswa kwezidakamizwa?

"Alfakltsidol" yokusetshenziswa nesiqondiso wochwepheshe bezempilo Kunconywa ukuba linqume ezimweni lapho umlando ulwazi mayelana osteodystrophy, ezingamahlalakhona kwezinso ukwehluleka esiteji. Ngaphezu kwalokho, kwathi isetshenziswa hypoparathyroidism. Isizathu ngokuba liyisihlalo yamathambo injongo, osteomalacia (umthamo nokwehlisa ithambo izicubu) bone ukuthambisa, ubunjalo bangahluka kakhulu. Lokhu kwakubangelwa ukukhumuzeka kwamathambo - a steroid, senile, postmenopausal - futhi iphathwa ngokuphumelelayo "Alfacalcidol" lisho ukuthini.

Umkhuba kuqokwa izidakamizwa ezimweni lapho isiguli uhlushwa lactic kwezinso, noma umlando it has Fanconi syndrome (isifo eziyinkimbinkimbi, kuhlanganise lactic kwezinso, sithwele ngofuzo nephrocalcinosis, yamathambo futhi mhlawumbe hypophyseal syndrome).

Njengoba sinazo zonke lezi zinkinga, "Alfacalcidol" ungakwazi ukunikeza usizo ngempumelelo.

kufanele uyeke Lapho kusukela ekutholeni?

Uhlu contraindications izidakamizwa iqukethe "Alfacalcidol" imfundo manual. Izibuyekezo ochwepheshe iyakwenqabela ngokuthatha izidakamizwa elinomlando kolwazi hypercalcemia, hyperphosphatemia (ngaphandle hyperparathyroidism lapho ekhula), gipermagnemii. Ungayisebenzisi le izidakamizwa uma lokudakwa i umzimba ezihambisana nokuqukethwe ngokweqile vitamin D3. Akwamukelekile ukuthi anikeze "Alfacalcidol" mums ubuhlengikazi.

Nokho, akubuzwa ukuthi awukwazi ukuthatha imithi nabantu hypersensitivity ngakunye izingxenye izidakamizwa.

Izicelo kanye umthamo

Ulwazi oluphelele kakhulu sendlela yokusebenzisa futhi iqukethe nokushintsha kokudla nokufakwa for the izidakamizwa "Alfacalcidol" imfundo manual. ifomu Product (amaphilisi ka 0.25 mg noma 1), umthamo kanye nesikhathi zokwelapha Yiqiniso udokotela akhethiwe ngamunye kuncike kobukhulu isimo lesiguli kanye ubunjalo isifo.

Ngokwesibonelo, iziguli omdala yamathambo, kubangelwa ukuhluleka kwamangqamuzana vitamin D3, izinkinga ne pheshana emathunjini, kumele zithole usuku inani umthamo 1 kuya ku-3 mg. A yi ngculaza imishanguzo hypoparathyroidism kuhambiselana kusukela mg 2 kuya ku 4 zomuthi ngosuku. ivolumu Nsuku zonke ngo ukuhluleka futhi kwezinso osteodystrophy umsebenzi kumele singeqi inani nomuthi 2 microgram. syndrome Fanconi futhi lactic kwezinso ngempumelelo isihloko belashwa "alfacalcidol" nesineke ethola umthamo wansuku zonke e volume of 2.6 micrograms. Phambi kweziguli yamathambo hypophosphatemic futhi osteomalacia ngempumelelo nsuku zonke umthamo isamba kungaba isukela micrograms 4 kuya ku-20.

Odokotela batusa ukuqala ukwelashwa nge umthamo ephansi, ethize ukuze isifo ngasinye. Ukwelapha kufanele ziqashwe plasma izici eziningana ezinjengolwazi calcium ne phosphorus (okungenani 1 ngesikhathi ngesonto). Isikali "alfacalcidol" ukwanda kuvunyelwe ngezinga elingekho ngaphezu kuka 0.5 micrograms ngosuku. Lapho umthamo ubuncane ngempumelelo kutholakala, okuqukethwe le-calcium egazini kumele kube control hhayi ngaphansi kuka njalo emavikini 3-5.

imiphumela engathandeki

Njenganoma yimuphi umuthi, kukhona uhlu side effects kanye kusho "Alfacalcidol." Yokusetshenziswa (elinomqondo ofanayo nelithi ngenhlanhla futhi nomphumela ofanayo) kuletha ezithebeni iziguli ukuthi izidakamizwa ungakwazi basabela isimiso sokugaya ukudla bungene. Ezimweni eziningi, isicanucanu, ukuhlanza, ubuhlungu epigastric, ukuqunjelwa noma isifo sohudo, isilungulela, umuzwa kome nolwelwesi lwamafinyila emlonyeni. Ingabe ukuvela nokuzincisha ukudla.

CNS side effects kungenzeka ubuthakathaka jikelele futhi ukozela, ukukhathala, ukuphathwa ikhanda nesiyezi. Ngezinye izikhathi iziguli asitshela yona ngokuthuthukiswa kwezinjongo ka tachycardia (okusheshayo kwenhliziyo) kanye nokwanda wegazi. ukusabela Dermatologic kungenzeka njengoba ukulunywa nesimungumungwane esikhumbeni, hhayi ukuthuthukiswa ijulile kakhulu amathambo, imisipha kanye nezinhlungu ngokuhlanganyela. Kuyohlukahluka amagugu laboratory maqondana ngaphezulu Isidlulisilwazi lipoproteins. Kukhona kungenzeka hypercalcemia, hyperphosphatemia (yalabo abaphethwe kwezinso ukusebenza izinso).

Ukweqiwa ngokweqile

Inani imihlola negative sizoba kwenzeka ukuthi kudlulwe kuvumelekile lesi sidakamizwa "Alfacalcidol" umthamo. Yokusetshenziswa kuxwayisa iziguli ingozi yokuba hypervitaminosis D. Izimpawu zokuqala ukweqisa izidakamizwa zibangelwa hypercalcemia. Kusukela gqamisa bhá iyiphi ukusabela kungenzeka emathunjini, ubuhlungu bemisipha, ukunambitheka metallic emlonyeni, ukukhathala.

Ngo ukudakwa ezingamahlalakhona iziguli ukubika ukozela nekhanda kungenzeka ubuthakathaka, ukucasuka, ukuqwasha, inkumbulo ukungakhuli, kanye nokukhula kancane wegazi. Ngo indlela yokwakheka igazi ngezinye izikhathi iqukethe amanani bokungasetshenziswa nitrogen ne creatinine. Kukhona ingozi hyperemia conjunctival, calcification of izinso, lung, izicubu zomzimba ezithambile negazi izitsha, ukwakheka of concretions e nezinso. Kungaba izinkinga izwi (hoarseness).

Ukuze ongaqeda imiphumela ngokweqile we imithi kumele amiswe, isisu ukugeza, nika, kuye ngokuthi izimpawu iluphu isisu, bisfofonaty, hemodialysis usebenzisa izixazululo ongaphakeme bagxila calcium.

Ukulinganiselwa zomuthi

Kunezindlela eziningana izifo lapho kubalulekile ukuba banakekele "Alfacalcidol." Yokusetshenziswa Kunconywa aphathe ngokucophelela isimo sempilo yabo ukuze iziguli isifo sokuqina kwemithambo yegazi, sarcoidosis (noma iyiphi enye zinhlobo granulomatosis), isifo sofuba yamaphaphu (isigaba asebenzayo), ukuhluleka kwenhliziyo futhi kwezinso esingamahlalakhona umsebenzi (ifomu zezifo ezingelapheki). Yiba ekhethwe uqaphele "Alfacalcidol" uma isiguli izimpawu nefrourolitiaza. Izingane kanye ezigulini esezikhulile futhi basengozini (isidakamizwa yokugcina kunganikeza umfutho ekuthuthukiseni isifo sokuqina kwemithambo yegazi).

Nokukhulelwa kanye lactation

Njengoba abesifazane abakhulelwe nabancelisayo, i- "Alfacalcidol" imfundo evumela ukusebenzisa kuphela ezimweni lapho kulindeleke umphumela ube muhle umama bulingana zempilo ezibangelwa womntwana nokuthuthukiswa.

Hypercalcemia e umama okhulelwe, cuphuluza eside ukusetshenziswa "alfacalcidol," anganikeza push ekuthuthukiseni eziningi izinkinga ku-fetus. Sezifo ezimbi kakhulu e umntwana ongakazalwa kungenziwa ngokuthi hypersensitivity uvithamini D, ngicindezelwe ukusebenza indlala parathyroid, stenosis yomthambo i-aorta, retardation engqondo, elfopodobnoy ethize syndrome Ingaphandle.

Ngaphezu kwalokho, "Alfacalcidol" imiqulu encane uyakwazi ngesikhathi lactation excreted e ngobisi lwebele. Ukuze ugweme ingozi izimpawu hypercalcemia e ingane, kubalulekile ukuba ehlelekile ukuthatha imithi ngokuqapha.

Ukuxhumana nezinye izinto

"Alfacalcidol" Umsebenzisi Isicelo Kunconywa ukuba ningawamukeli parallel anticonvulsant (barbiturates, phenytoin, nokunye. D.) Ngenxa yokwanda yayo ( "alfacalcidol") umzimba. Okuphambene ithonya inhibitor. Isicelo se-nomuthi ngokuhlanganyela ejenti equkethe digitalis, ungakwazi avuse ukuthuthukiswa arrhythmias.

Kuyaphawuleka incipha ukumuncwa "alfacalcidol" ngokulinganisa ukuba yokuvuma yayo albumin, i antacids, uwoyela amaminerali, colestipol, colestyramine, sucralfate.

Inhlanganisela laxatives magnesium-aqukethe noma antacids, kwandisa amathuba gipermagniemii noma giperalyuminemii. Lapho ebonisa indlela lo "alfacalcidol" ngemithi yokwelapha, kokuba ukubunjwa Vitamin yayo D noma yimiphi nemikhiqizo yalo, wandise nengozi yokuba hypercalcemia.

imiphumela Toxic "alfacalcidol" is kakhulu ziyancipha parallel ke isicelo tocopherol, ascorbic acid kanye pantothenic acid, thiamin, riboflavin, Vitamin A. Umthelela ukuchayeka "alfacalcidol" ingaphansi okukhulu khona okunye futhi etindronoy pamidronic acid, glucocorticoids, kaltsitona. Ngaphezu kwalokho, lokhu izidakamizwa kuvusa ukumuncwa izinto phosphorus-equkethe, okwandisa ingozi yokuba hyperphosphatemia.

izidakamizwa ezifanayo

butholakale ngoba izidakamizwa "Alfacalcidol" analogue emakethe zemithi lizwe. Yokusetshenziswa iqukethe ulwazi labo ephumelela kunazo. Lezi zihlanganisa izidakamizwa "Etalfa", "Alpha-D3 Teva", "Ca-Alfadol", "alfa-Wang", "Oksidevit", "Tevabon".

Lezi abakhiqizi izidakamizwa nikeza abathengi ezihlukahlukene amafomu: amaphilisi kanye gelatin amaphilisi, sehla kanye powder, izixazululo ukumnika emthanjeni.

Izibuyekezo sokulungiselela "Alfacalcidol"

Noma yimuphi izidakamizwa has abasekeli kanye nezitha, njengoba nje kunjalo ukulungela "Alfacalcidol." Yokusetshenziswa, izithombe zeziguli eziye weneliseka ithonya bafakela umzimba, ezikwenza ucacelwe abathengi ukuthi izidakamizwa kungaba ngokuphawulekayo ngcono izinga komuntu ukuphila nabantu abaningi yizifo ezihlobene nokungabikho nokuntuleka amavithamini namaminerali, umzimba calcium-phosphorus. Ngaphezu kwalokho, "Alfacalcidol" uyakwazi nje isimo izinwele nezinzipho, okuyilona elisebenzayo futhi kubalulekile.

Ezinye iziguli unganelisekile yokuthi "Alfacalcidol" azikwazi ukuthengwa emakethe evulekile, njengoba kudinga kadokotela lukadokotela. Nokho, ochwepheshe bezempilo zinombono ukuthi amalungiselelo ezibalulekile ezinjengalezi, futhi akufanele kube kufinyeleleke kuwo wonke umuntu.