Umuthi 'Topamax ": Izimpendulo iziguli nodokotela

Ngempumelelo uma izidakamizwa ezinjalo, njengoba "Topamax"? Uphenyo kodokotela kanye neziguli izokwethulwa ngezansi. Futhi, uzofunda kulokho kuleli kheli le-izidakamizwa kumele kusetshenziswe futhi yiziphi izici zokwelapha it libhekene.

Ukwakheka, umumo

Ngayiphi efomini ngokuthengisa isidakamizwa "Topamax"? Nobufakazi ukubika ukuthi leli thuluzi angathengwa ngesimo gelatin amaphilisi, elimhlophe okuqinile.

Isithako asebenzayo we umuthi topiramate. Futhi e ngezithako zawo kuhlanganisa izinto ezilandelayo asizayo: ushukela oluthile lokudla, povidone, kanye cellulose acetate.

Ukudayiswa kwezidakamizwa "Topamax" (ukubuyekezwa odokotela ngakho kukhona uhlamvu edidayo kakhulu) iza amabhodlela epulasitiki kanye amaphakethe of amakhadibhodi ngokulandelana.

Izimpawu izidakamizwa

Yiziphi amaphilisi "Topamax"? Izibuyekezo babike ukuthi lokhu izidakamizwa antiepileptic, esiphathelene fructose. isici sayo yokusebenza ukwazi zivimbela iziteshi sodium, kodwa futhi inciphise ukuqhubeka okuphindayo isinyathelo nekhono e depolarization eside izindonga namangqamuzana ezinzwa.

Reception nokubika izindlela kwandisa umsebenzi γ-aminobutyric acid maqondana kohlobo oluthile Gaba-receptor. Ngaphezu kwalokho, izidakamizwa esebenzayo uyakwazi uvimba ukusebenza kainate ukuba glutamate receptor, nokulawula umsebenzi Gaba-receptor. imiphumela enjalo zokwelapha ezihlobene-umthamo izidakamizwa futhi okuqhubekisela okukushoyo egazini 1-205 micromolar.

Yiziphi ezinye izakhiwo nobuntu izidakamizwa "Topamax"? Izibuyekezo asho ukuthi isithako zako ezisemqoka uyakwazi zivimbela umsebenzi inombolo carbonic anhydrase ka isomers. Kufanele kuqashelwe ukuthi kobukhulu izakhiwo kwemithi zomuthi abasakwazi kunabayeni carbonic anhydrase inhibitor, okusho acetazolamide. Umsebenzi onjengalona zomuthi akuyona esiyinhloko wesenzo antiepileptic.

izici Kinetic ekulungisweni

Kungakhathaliseki imithi ugxile "Topamax"? Izibuyekezo bathi ngemva kokuthatha yalolu ketshezi asebenzayo kusho ngokushesha kakhulu ugxile kusukela amathumbu. Kanjalo bioavailability of topiramate ifinyelela 81%. Ukudla ukudla akunamthelela le nkomba.

Yokubopha asebenzayo izidakamizwa ingxenye ku-plasma amaprotheni ifinyelela 13-16%.

Ukuze sifinyelele yakhoibrium e ngabanye nge umsebenzi evamile izinso kungase kudingeke mayelana 4-8 izinsuku. Uguquko asitholayo mayelana 20% umthamo mali yazo. Loku metabolites eziyisithupha (akusebenzi).

Topiramate, kanye zonke nemikhiqizo yalo, isuselwe nezinso. Ngalesi sikhathi isigamu-ukuphila kwabo amahora 22.

Izinkomba ukuthola amaphilisi okwelapha

Kwezinye izimo, iziguli ekunike umuthi "Topamax"? Izibuyekezo migraine akhayo kuphela. ukulungiselela Okubukwe isetshenziswa hhayi kuphela ekwelapheni wathi isifo esithinta izinzwa, kodwa futhi ukuze kuvinjelwe yayo.

Kufanele kuphawulwe ukuthi leli thuluzi kubonakala kahle ngokwaso isithuthwane. Isetshenziselwa monotherapy izingane kusukela eminyakeni emibili ubudala kanye nabantu abadala. Ngaphezu kwalokho, "Topamax" ngokuvamile Kunconywa ukuthatha abantu abanale esanda kutholakala ukuthi uphethwe yini.

Njengengxenye yokwelapha eziyinkimbinkimbi yalesi izidakamizwa kuboniswa izingane ezigulini mibili omdala esinqunyiwe noma tonic-clonic nokuquleka generalized, kanye ukwelapha Lennox-Gastaut syndrome.

Izimo ukuthola amaphilisi okwelapha

Kwezinye izimo, awukwazi ukuthatha amaphilisi "Topamax"? Ukubuyekezwa (izingane ezingaphansi kweminyaka emibili lokhu izidakamizwa is contraindicated) ithi Okubukwe izidakamizwa akufanele isetshenziswe ezigulini hypersensitive ukuba izingxenye zalo.

Ngokucophelela okukhulu kumele kusetshenziswe lo muthi ne yokwehluleka kwesibindi, nefrourolitiaze, ukwehluleka kwezinso futhi hypercalciuria.

nokushintsha kokudla nokufakwa

Yamukela izidakamizwa "Topamax" kufanele sinikezwe ngomlomo. Amaphilisi kungenziwa kugwinywe lonke, futhi kungenzeka ukuba uhlanganise okuqukethwe kokuncinyane ukudla elithambile.

Ukuze control of zesifo sokuwa yokwelapha Kunconywa ukuqala ongaphakeme reception nomuthi imithamo, bese titrated kuze kube esebenza kahle yabo.

Lapho nokuquleka tonic-clonic futhi lesi sifo Lennox-Gastaut ubuncane umthamo ngempumelelo zomuthi 200 mg ngosuku. Kwezinye izimo, seziguli ezithola umthamo sangemihla ungaboniswa elilingana 1600 mg.

Ezinganeni iminyaka emibili umthamo watusa nsuku zonke 5-9 mg ngayinye kg esisindo.

Indlela esiphatha ngayo izidakamizwa kufanele kuthathwe nesifo sokuwa? Monotherapy abadala enqunyiwe 25 mg kanye ngosuku isonto elilodwa. Ngaphezu kwalokho, kule nombolo kukhuphuke ngo 25-50 mg zonke 1-2 amasonto.

Umthamo Kunconywa monotherapy of isithuthwane izingane ziyahlukahluka uhla 100-400 mg ngosuku.

Ukuze kuvikelwe migraine lokhu izidakamizwa kufanele uthathe 50 mg kabili ngelanga. Uma kudingeka, umthamo kungenziwa lenyuke (kufika ku ukuqala ukusebenza emitholampilo).

ohlangothini-imithelela uhlamvu

izidakamizwa Okubukwe kungabangela ezihlukahlukene ohlangothini ukusabela. Ngokuvamile wabonakaliswa zimi kanje:

• ukozela, ubuthakathaka bomzimba, isiyezi, ukundindizela, ukunganakwa, apraxia, ukucabanga okungavamile, ukulahlekelwa amandla okukhumbula, kusebentisana kahle, dystonia;
• ukudideka, ukukhala, ukucabanga kancane, ukuhhema, ukucindezeleka, kwehle libido, isimo sengeneme, ukusabela nolaka;
• sokuzincisha ukudla, pancreatitis, kolwelwesi, ukubuyisa, izimpawu dyspeptic;
• zibe, amajaqamba, ukuvuvukala emalungeni;
• ubumpumputhe sohlangothi olulodwa, presbyopia, edema conjunctival, nabanye.

Nomuthi "Topamax": Izibuyekezo

Isifo sokuwa - isifo eyinhloko lapho izidakamizwa kunikezwa ukucabangela. Ngokusho kwemibiko odokotela nge uphethwe le imithi njalo sibonise kusebenta eyanele zokwelapha. Ngaphezu kwalokho, kuthuthukisa sebuningini reception ohlangothini ukusabela, kuhlanganise ingxenye isimiso sezinzwa futhi psyche.

Njengoba for iziguli, nabo ukhombe tolerability abampofu izidakamizwa. Yingakho abaningi babo bakhetha ukusebenzisa ngaphezulu uvikelekile izimali bona udokotela uncoma.

Asinakusho ukuthi izidakamizwa okukhulunywa kabanzi iziguli eziningi njengendlela ulahlekelwe isisindo. Nokho, ochwepheshe ukubika ukuthi uma nithatha Amaphilisi "Topamax" ngalezi zinhloso kufanele kucatshangelwe ubuthi yaso ephezulu.