Tablets "fenigidin": yokusetshenziswa, ngempela

Kuyini imithi lalisho ukuthi "fenigidin"? Yokusetshenziswa wemishini yezokwelapha, Izimo yayo, side effects kanye analogs zichazwe ngokuningiliziwe kulesi sihloko. Ngaphezu kwalokho, uyofunda lapho unikezwa izidakamizwa (izinkomba), kulokho Isikali kumele athathwe, abakushoyo ngakho, iziguli kanye nodokotela.

Ukwakheka kanye nefomu wokukhulula izidakamizwa

Izidakamizwa "fenigidin" zingatholakala Pharmacy ifomu iphilisi. Ziyakwazi camera futhi liqukethe isithako ezifana nifedipine. Ngo ukudayiswa agent zokwelapha ilethwa ebhokisini ibhokisi, lapho kungaba noma zithutha 40, noma 50.

Siphinde bahlola nomuthi kungenziwa imakethwa njengoba isixazululo kwezokuphatha emthanjeni noma intracoronary. Lesi sidakamizwa iqukethe isithako ezisebenzayo ezifanayo tablet.

izici kwemithi izidakamizwa

Uyini izidakamizwa "fenigidin"? Yokusetshenziswa zomuthi uthi kuba abakhethayo -calcium channel blocker ekilasini 2, futhi dihydropyridine nemikhiqizo.

Lo mshini wezenzo yalesi izidakamizwa ukuthi siyehla calcium kwatheleka e amaseli semithambo imisipha bushelelezi futhi cardiomyocytes. Imithi uyakwazi banethonya hypotensive nemiphumela antianginal. Iphinde wenabisa neuropathy nemithambo yegazi yenhliziyo, kwehlisa ithoni nemikhumbi, kunciphisa umfutho wegazi, letindzala ukumelana semithambo, contractility esivimba amanzi, isidingo imisipha yenhliziyo oksijini kunciphisa afterload enhliziyweni. Ngaphezu kwalokho, izidakamizwa kakhulu ngcono yenhliziyo ukugeleza kwegazi.

Tablets "fenigidin" unomsebenzi esincane noma abangenaso nhlobo anti-arrhythmic. Ngaphezu kwalokho, abazi sicindezeleke conduction esivimba amanzi.

Pharmacokinetics zomuthi

Lapho amuncwa umzimba izidakamizwa "fenigidin"? Imiyalelo isicelo ithi ngemva ukwamukelwa amaphilisi ku nempahla yabo okusebenzayo ngokushesha ugxile kusukela ipheshana wokugaya ukudla. Umuthi is akheka esibindini. Lokhu kwenzeka lapho "pass kuqala", okuholela kwetinhlavu metabolites esingasebenzi.

amaprotheni nomuthi ngibopha cishe 92-98%. Ingxenye-ukuphila sihlala 2 h.

Ihamba izidakamizwa izidakamizwa njengoba metabolites ngefomu unmodified (e trace amanani) ikakhulukazi izinso. Futhi, umuthi okukhipha ngokusebenzisa emathunjini (u-20%).

Izinkomba ukusetshenziswa kwemithi

Uma kukhona odokotela ngeziphambeko linqume iziguli zabo umuthi ngokuthi "fenigidin"? Ukusetshenziswa kwalesi izidakamizwa kuboniswe izimo zokucabanga okubangelwa isifo ezilandelayo:

• ukuze kuvinjelwe ukufa uhlangothi, kuhlanganise angina vasospastic;
• I-ngempumuzo angina;
• e zinhlekelele abanomfutho wegazi ophakeme;
• unomfutho wegazi ophakeme;
• isifo Raynaud sika.

Izimo ukusetshenziswa imithi

Kwezinye izimo, akunakusetshenziswa akufanele zaphathwa isiguli lesi sidakamizwa "fenigidin"? Yokusetshenziswa izibhebhe olucutshungulwayo uthi basuke contraindicated ku lokuchezuka ezilandelayo:

• usashaqekile cardiogenic;
• lwemithambo hypotension (systolic blood pressure lapho inenani engaphansi kuka-90 mm HG ..);
• e ezinzima stenosis yomthambo i-aorta;
• ngesikhathi nciphisa;
• ukuhluleka inhliziyo ezinzima;
• uma isiguli ezwela eyengeziwe element asebenzayo ezifana nifedipine.

Izindlela kwesicelo nesilinganiso zomuthi

Umuthi 'fenigidin "ukucindezela ezinqunyiwe kuphela iziguli ngamunye. Ukuze abaphathi temlomo umthamo kokuqala 10 MG kane ngosuku.

Uma wayefisa, ivolumu imithi liyakhula kancane kancane. Kulokhu, umthamo kungaba 20 mg kane ngosuku.

Ezimweni ethile yomtholampilo (isib okufana angina, noma okunzima hypertension) isikhathi esifushane uvunyelwe ukwandisa umthamo zemithi 30 mg kane ngosuku.

Ukuze asebenze ngokuzimisela ukuze kuboshwe crisis unesifo sikashukela, kanye angina, umuthi ingasetshenziswa non-ngemlomo nangekubhala sublingually. Kulokhu iqondiswa i inani 10-20 mg (akuvamile 30 mg).

Ukuze impumuzo esibucayi unesifo sikashukela angina nomuthi asebenzayo ngezinye izikhathi iqondiswa ngemithambo yegazi (5 mg amahora phezu 4-8).

bolus Intracoronary solution izidakamizwa iqondiswa 100-200 mg. Impatho enjalo ngokuvamile eyenziwa elokususa acute yenhliziyo Umthambo zibe. stenoses Umhlinzi umthamo kokuqala kufanele ibe mayelana 50-100 micrograms.

esiphezulu I umthamo wansuku zonke kubhekwe yithi nomuthi phezu ukungenisa 120 mg. Ukuze abaphathi emthanjeni, umthamo yayo kumele singeqi 30 mg.

imiphumela emibi izidakamizwa

isixazululo intravenous kanye amaphilisi "fenigidin" singabanga inani kahle esikhulu amathuba okuba nemiphumela engemihle. Hlobo luni cabanga njengamanje:

• Isimiso senhliziyo nemithambo yegazi: asystole, ngamanzi kwesikhumba, tachycardia, ventricular, lokujabulela ukushisa, okwandisa angina ukuhlaselwa, tachycardia, edema neuropathy, hypotension, bradycardia.
• Neuropathy futhi uqondiswe isimiso sezinzwa esiyinhloko: ubuhlungu bemisipha, ubuhlungu bekhanda, ukukhanya ukuphazamiseka visual, paresthesia, ukuphazamiseka kokulala futhi liqhaqhazela.
• Ukugaya: nohudo, ukucanuzela kwenhliziyo, eziya ziba zimbi isibindi, Hyperplasia baby. ' Uma usebenzisa izidakamizwa isikhathi eside kakhulu, futhi ebulilini, kungase kube dyspepsia, cholestasis intrahepatic futhi transaminases isibindi aphakeme.
• hemopoiesis uhlelo: kakhulu kuyaqabukela waphawula thrombocytopenia futhi leukopenia.
• Endocrine System: gynecomastia akuvamile uyalandelwa.
• uhlelo urinary: ukwandisa nsuku okukhipha umchamo. Uma uthatha le izidakamizwa isikhathi eside futhi ebulilini, kungase kube ukuhlukumeza nezinso.
• Yokungezwani komzimba: ukuqubuka kwesikhumba.
• ukusabela Wasekhaya: uma ujova izidakamizwa ngemithambo yegazi, kungenzeka burning at isayithi umjovo.

Omunye akufanele sikhohlwe ukuthi umzuzu owodwa ngemva kokuphathwa intracoronary, isiguli kungase kubonakale imiphumela emibi inotropic ka nifedipine futhi ukwandisa ukushaya kwenhliziyo nomfutho wegazi. Lezi zimpawu ziyaphela kancane kancane ngemva kwemizuzu engaba ngu-8-15.

izidakamizwa nokuxhumana neminye imithi

Ingabe thina, kanye nezinye izidakamizwa ukuthatha imithi "fenigidin Health '? Imiyalelo ebiyelwe isembozo, exwayisa ngokuthi impilo yabantu kungase kakhulu ukuwohloka uma sisuke sicabanga ukusebenzisa imithi ngendlela efanele. Kule ndaba, ngaphambi idili sincoma ukuthi bonana nodokotela wakho kuqala.

Lapho kungenzeka isicelo kwesikhathi esisodwa kwama-isisu, ama-ejenti antihypertensive futhi phenothiazine nemikhiqizo ukugqanyiswa inciphise umfutho wegazi ophakeme ka nifedipine.

Nge ukusetshenziswa ngesikhathi esisodwa izidakamizwa anticholinergic kungenzeka ukunakwa inkumbulo kahle iziguli ngaphambi kokuthatha umhlalaphansi futhi umhlalaphansi.

Uma ngesikhathi esifanayo ukuthatha izidakamizwa beta-blocker ke umuntu angagcina ezinzima lwemithambo hypotension, futhi kwezinye izimo - futhi senhliziyo.

Nge ukusetshenziswa ngesikhathi esisodwa nge-nitrate kwandisa imiphumela antianginal ka nifedipine.

Alahlwayo reception calcium kunciphisa ukusebenza kahle timphawu asebenzayo. Lokhu sihlotshaniswa nokuxhumana abasiphikisayo ngenxa emakamu anda-calcium ion in the okuthiwa uketshezi extracellular.

Akwaziwa amacala imisipha ebuthaka, ukuntula ukukhathala jikelele ngenkathi ngokuthatha izidakamizwa ne-magnesium nosawoti.

Uma usebenzisa "fenigidin" kanye digoxin, kungaba ukubambezela kokususwa yokugcina emzimbeni, okuyinto ke kuba nesizathu ukwanda emakamu yayo egazini.

Yesikhathi umthamo owodwa we imithi nge diltiazem sithuthukisa inciphise umfutho wegazi ophakeme.

Nge ukusetshenziswa ngesikhathi esisodwa theophylline singashintsha ku lokuhlushwa yokugcina ku-plasma yegazi.

izidakamizwa rifampicin uyakwazi ukuyenga isibindi enzyme umsebenzi futhi ukusheshisa umzimba nifedipine okwagcina kuholela ukwehla okukhulu ekulenzeni libe namandla.

Uma ukusetshenziswa kwezidakamizwa ngesikhathi esifanayo ne phenytoin, phenobarbital futhi carbamazepine, amathuba abanciphisa lokuhlushwa ketshezi asebenzayo oketshezini olungenambala lwegazi.

Kukhona kunemibiko eminingi ukwenyuka nifedipine plasma lokuhlala nokwenyuka AUC kwayo isicelo olulodwa itraconazole futhi i-fluconazole.

Uma uthatha le izidakamizwa ne fluoxetine, kungenzeka ukuqinisa imiphumela emibi nifedipine emzimbeni womuntu.

Ezimweni ezingavamile, ukusetshenziswa concomitant imithi nge quinidine kunganciphisa lokuhlushwa yokugcina egazini futhi asuse izidakamizwa - ukwandisa ke, lapho, yebo, laba kanjani nesandla prolongation we qt kweminyaka electrocardiogram.

izinto asebenzayo ezifana ranitidine futhi cimetidine, ngezinye izikhathi ukwandisa lokuhlushwa nifedipine egazini, okwandisa umphumela wawo antihypertensive.

Imithi equkethe utshwala kungase kwandise imithelela nifedipine, okubangela isiyezi kanye nezinye ukusabela ezingezinhle.

Medicine "fenigidin" phakathi nokukhulelwa kanye lactation

Lilawulwa futhi izifundo ezanele ukuphepha isici asebenzayo ezifana nifedipine ngesikhathi sokukhulelwa akubanga. Ngakho-ke, zisebenzise lokhu izidakamizwa ngesikhathi sokukhulelwa is hhayi Kunconywa.

Ngenxa yokuthi nifedipine ikhishwe kanye obisini lukamama, kufanele ugweme ukusebenzisa kwayo ngesikhathi ukuncelisa ingane noma ukunqanda lactation.

Ngo izifundo zokuhlola lwembula imiphumela embryotoxic, foetotoxic futhi teratogenic ka nifedipine emzimbeni wentombi.

Analogs nomuthi

Umuthi ungayithola enye "fenigidin"? Analogue kwaleli thuluzi etholakala ngazo zonke Pharmacy. Phakathi kwabo kukhona imithi ezilandelayo: "Adalat", Sponif "," Vero Nifedipine, "" Sanfidipin "," Zanifed "," Osmo-Adalat "," Kaltsigard kuthiye ukukhula "," Nifecard "," Kordafen "," Nifelat " "Kordafleks", "Nifedipine", "cordipin", "Nifedikor", "Corinfar", "Nifedikap", "Nikardiya", "Nifedeks", "Nifadyev", "Nifegeksal", "Nifebene" nabanye.

Nikeza lezi zimali kufanele udokotela kuphela.

Medicine "fenigidin": ukubuyekezwa kodokotela kanye neziguli

Ochwepheshe uqaphele ukuphumelela izidakamizwa "fenigidin". Kwasheshe aqede angina, kanye kusiza zinhlekelele abanomfutho wegazi ophakeme, isifo Raynaud sika, kanye nomfutho wegazi ophezulu. Nokho, phezu ingxenye iziguli, zikhona izimpendulo eziningi ezimbi ngalokhu nokulungiselela. Ngokusho kwabo, kudala eminingi engemihle. Kakhulu njalo wabonakaliswa kukhona lapho ukhwehlela nobuhlungu bomzimba nesiyezi. Nokho, odokotela bathi ukusabela okunjalo kungenzeka kuphela uma isicelo engalungile zomuthi. Kule ndaba, kungako kumele isetshenziswe kuphela ngaphansi kokuqondisa onguchwepheshe, ikakhulukazi uma isiguli acute isilethikusebenza, okunzima kwegazi cerebral, isifo sikashukela, izifo kwesibindi nezinso, kanye nomfutho wegazi ophezulu okubulalayo nokuhlala hypovolemia.