"Eufillin": ukubuyekezwa. "Eufillin": izinkomba ukusetshenziswa

Uyini izidakamizwa "Eufillin"? Izibuyekezo lokhu nomuthi, izinkomba zayo, izindlela kwezicelo kanye nemiphumela engemihle sethula kulesi sihloko. Uzofunda mayelana ifomu kuwo elitholakalayo izidakamizwa futhi ngaleyo ntengo.

Uhlolojikelele

Ukulungiselela "Eufillin" okuyinto izilinganiso zahlukahlukene kakhulu, buyisidakamizwa bronchodilator. Lo muthi kungokwalabo iqembu xanthine. Nokho, angathengwa cishe zonke ekhemisi, ukusebenzisa izidakamizwa ezifana ngezinhloso zokwelapha, kuyinto efiselekayo oda kuphela kadokotela.

Ukuma kanye nendlela okwakheke ngayo ukukhululwa izidakamizwa

Okwamanje izidakamizwa itholakala amafomu ezimbili ezihlukene, okuyilezi:

• Ngo amaphilisi, aqukethe 150mg esemazweni asebenzayo ezifana aminophylline. Ngo ukudayiswa izidakamizwa esebenzayo ingena ibhokisi 50, 10, 30 noma 20 izingcezu.
• Izidakamizwa "Eufillin" e ampoules. 2.4% isixazululo imijovo (1 ml) iqukethe 24 aminophylline mg.

Ngalokho uhlobo izidakamizwa ezisetshenziselwa ukwelapha isifo, kufanele bancome kuphela adla udokotela.

izakhiwo zomuthi

Njengoba kushiwo ngenhla, lesi sidakamizwa "Eufillin" e ampoules noma amaphilisi iqukethe ikhemikhali eyisisekelo - aminophylline. Ngakwelinye ihlangothi, ingxenye esebenzayo inhlanganisela esakhiwa 80% kuya ku-20% theophylline futhi ethylenediamine. Lesi sakhiwo kusiza kakhulu solubility zomuthi, futhi kakhulu ngcono ukumuncwa yayo.

Izidakamizwa "Eufillin" kulokho sabelwe odokotela? Izinkomba ithuluzi ngenxa umphumela wawo bronchi. Ngakho, nomuthi "Eufillin" uyakwazi ukubeka umoya phansi le bushelelezi kwemisipha izicubu zomzimba wathi nekugwema cramping Kwabenza. He is impela ekuthuthukiseni umsebenzi we cilia EPITHELIAL yaleli pheshana yokuphefumula, kodwa futhi kwandisa ukusikwa we intercostal, imisipha diaphragmatic nezinye izicubu.

Uyini isici "Eufillin" izidakamizwa? Nobufakazi bathi lokhu izidakamizwa uyakwazi sikhuthaze isikhungo zokuphefumula ku oblongata medulla nokuthuthukisa ukupholisa yamaphaphu, bazogcwalisa igazi nomoya-mpilo ukuze unciphise okuqukethwe kwayo-carbon dioxide, okusho kujwayeleke umsebenzi zokuphefumula.

Umgomo we operation ye nomuthi

Lo mshini wezenzo emelelwa izindlela ukuthi kuvimbela enzyme phosphodiesterase, lapho izicubu aqoqana eyindilinga adenosine monophosphate, futhi yehlise ukugeleza calcium ion ku amaseli, okuyinto banesibopho ukusikwa kwemisipha, nokuthi ephumula imisipha abushelelezi bronchi.

Kufanele kuqashelwe ukuthi le izidakamizwa "Eufillin" (ampoules, amaphilisi) iyakhona inkanuko umsebenzi inhliziyo, ngenxa imvamisa namandla ukusikwa esivimba amanzi anda. Yena kwehlisa ithoni imithambo yegazi kwezitho ezifana izinso, ubuchopho, futhi isikhumba.

Ukunikeza umphumela eziphumulele ezindongeni ngemithambo emikhulu nemincane yokujikeleza kwegazi eliya emaphashini, i nomuthi kusiza ukuphungula ingcindezi kulo. Ukusebenzisa izidakamizwa "Eufillin" kakhulu ngcono igazi ligeleze nezinso. Ngenxa yalesi khudlwana kwetinhlavu kanye, ngenxa yalokho, le excretion of umchamo. Kusho siyehla platelet wokuhlanganisa. Asinakusho ukuthi "Eufillin" kwenza amangqamuzana abomvu egazi amelana umonakalo. Ngamanye amazwi, it kakhulu ngcono izakhiwo rheological yegazi.

Tocolytic eyaziwa mayelana nemiphumela yalesi izidakamizwa ku kwesibeletho. Futhi-ke uyakwazi okwandisa asidi of juice esiswini.

Absorption nokuqeda

Izidakamizwa "Eufillin" - ngu esetshenziswe kuwo iziguli? Ngaphambi kokuba siphendule lo mbuzo, kumelwe kushiwo ukuthi lokhu izidakamizwa kahle ugxile kusukela isimiso sokugaya ukudla bungene. Bioavailability kuze kube cishe ngo-100%, kanti ngesikhathi esifanayo ukuthatha ukudla ukumuncwa zomuthi kungaba ngokuphawulekayo ukubambezela.

Lesi sidakamizwa lingena singene ubisi nabancelisayo futhi akagcini phambi isithiyo esinomhlapho. Umzimba izindlela kwenzeka kuphela esibindini. excretion Kusuka umzimba womuntu ngokusebenzisa nezinso.

Nomuthi "Eufillin": izinkomba ukusetshenziswa

Ukulungiselela "Eufillin" ebekiwe obstructive ukucinana kwemithambo yomoya emaphashini, ukususa ukuhlaselwa kwakhe isifuba somoya (in iziguli isifuba somoya ukucindezeleka okungokomzimba njengenhlangano adjunct nezinye izinhlobo) ezinesimo asthmaticus (kuphela lihambisana zokwelapha), esingamahlalakhona senhliziyo ebuthaka, ukwelashwa kuhlangene unhlangothi nendlela nezinye izimo ischemic zobuchopho, pectoris angina, Cheyne-Stokes emishinini yokuphefumula, emphysema yamaphaphu, edema yamaphaphu, nezinye kwezinso okuhlotshaniswa amile. Impendulo ezigulini nomuthi "Eufillin" (Isixazululo for imijovo emthanjeni kanye amaphilisi) ngempumelelo kwehlisa ingcindezi kuleso simo esibucayi abanomfutho wegazi ophakeme. Livame ukusetshenziswa ngoba impatho yokuphelelwa umoya ezisanda kubelethwa, ukuthi lisesimweni esibonakala by ukumisa zesikhathi ukuphefumula (amasekhondi angu-15), futhi ephelezelwa iziyaluyalu ezifana bradycardia futhi cyanosis.

Izimo ukusetshenziswa

I nomuthi "Eufillin" (izinkomba ukusetshenziswa kwalesi izidakamizwa ahlanganisa okungakhulunywanga) has a inombolo enkulu Izimo.

Ngakho, wethule imithi Kunconywa ukuba kusetshenziswe ngoba impatho, uma uye wayibona okungenani eyodwa imicimbi elandelayo:

• hypersensitivity ukuba omunye izinto ephambili, kuhlanganise nemikhiqizo element ezifana xanthine (pentoxifylline, i-caffeine, theobromine);
• nomfutho wegazi ophezulu;
• arrhythmia;
• isilethikusebenza;
• myocardium zokugula;
• ukuhluleka kwenhliziyo;
• isilonda 12 duodenal isilonda noma esiswini;
• oyingozi noma ezingamahlalakhona (ikakhulukazi esigabeni acute) kolwelwesi;
• isifo sohudo,
• wendlala adenoma;
• inhliziyo yamaphaphu;
• isifo fibrocystic kwebele;
• hypoxemia;
• ukuluthwa utshwala;
• i-hyperthyroidism;
• umkhuhlane;
• yezifo ingemuva;
• zokuphefumula ipheshana izifo;
• ukwephula kwesibindi;
• oyingozi noma nesifo esingamahlalakhona kwezinso;
• edema syndrome;
• ibele;
• hypernatremia;
• sokukhulelwa.

Yokusetshenziswa

Ngesimo isixazululo iqondiswa intramuscularly noma ngemithambo yegazi. Kufanele kuqashelwe ukuthi abaphathi parenteral yalesi izidakamizwa isetshenziswa kuphela ezimweni eziphuthumayo kanye eziphuthumayo. Kulokhu umthamo imithi ibalwe ngamunye futhi ancike ngesilinganiso excretion zabantu ezahlukene, kobukhulu isimo lesiguli kanye isisindo emzimbeni.

Yimiphi imithetho okudingeka ukwazi ukuze ngemithambo yegazi bafake lesi sidakamizwa "Eufillin"? Ukuvuza zomuthi kufanele ibekwe ngokucophelela, futhi okubaluleke - kancane.

Ngokusho umyalelo, abantu abadala ezimweni eziphuthumayo, umthamo we izidakamizwa kukhethwa ngesilinganiso 6 mg ngayinye isisindo 1 kg. Ngenxa yalesi izidakamizwa kufanele buhlanjululwe e-20 ml nosawoti "sodium chloride" bese ufaka izidakamizwa ngemithambo yegazi. Umjovo Kwenziwa kancane kakhulu (imizuzu phezu 5-8).

Uma isiguli isimo somoya ke kunikezelwe izidakamizwa infusional e isamba 720 noma 750 mg. Isikhathi salesi ukwelashwa kufanele singadluli ezingu-14.

Ukuze akhulule isimo lesiguli yezifo obstructive yamaphaphu (ikakhulukazi ngesikhathi sesigaba acute), ukwethulwa kwe-izidakamizwa ziqale umthamo 5 noma 6 mg ngayinye 1 kg isisindo nesineke. Uma kudingeka, kungase kube ngcono. Nokho, lokhu kufanele kwenziwe ngokucophelela okukhulu, ukulawula igazi isithombe.

Ngokuqondene amaphilisi ke lokhu "Eufillin" lecokwe 0.15 g emva kokudla kanye noma kathathu ngosuku. kokuthola Yiqiniso ingahlala izinsuku eziningana noma izinyanga.

zokuphelelwa umoya Neonatal umthamo kokuqala agent 5 mg ngayinye 1 kg esisindo ngosuku (ngemithamo ezimbili). Kulokhu, lesi sidakamizwa iqondiswa tube nasogastric. Ngemva ngcono kufanele niqhubeke yokwelapha yesondlo (2 mg ngayinye 1 kg usuku 2 ngemithamo ahlukaniswe). Isikhathi ekwelapheni lesi sifo kungase kube amasonto ambalwa noma izinyanga.

izidakamizwa Omncane nangaphezulu ezinqunyiwe kuncike inkomba nokugasela ngamandla isimo. Umthamo wansuku zonke uyahluka 6-15 mg ngayinye isisindo 1 kg.

Inhalation "aminophylline"

Umuthi kuyinto ukucinana kwemigudu yokuphefumula esisemqoka obstructive. Lokhu kungenxa yokuthi kwenza kubelula ukuthi ukususwa isikhwehlela futhi amashubhu bronchial ubabonisa izitsha kahle. Ngo amakhabethe physiotherapeutic, okuyizinto umtholampilo ngamunye, izinqubo ephefumula wenziwa ngesisekelo umthamo omkhulu ithuluzi. Ngakho, ampoules 3 ampoule nomuthi 10 kufanele asebenzise "Diphenhydramine" futhi 500 ml amanzi. Lapho isetshenziswa ukwelapha i-evamile compressor nebulizer, ke lokhu umthamo kuyoba ingasaphathwa, nakuba olinganise kufanele kugcinwe.

Ngaphambi ukuzalaniswa kwamahhashi kanye zisebenzisa "Eufillin" ephefumula umntwana, qiniseka uthintane wabantwana.

Imiphumela engemihle

Ngokwe-nokubuyekezwa, "Eufillin" izidakamizwa kungabangela enjalo engemihle njengoba isiyezi, ukuqwasha, ukungahlaliseki ngokweqile, ikhanda njalo, arrhythmia, eliqhaqhazelayo wemikhawulo, umfutho ophansi wegazi, ubuhlungu besisu, palpitations, ukucanuzela kwenhliziyo, ubuhlungu benhliziyo, isilungulela, komzimba ukuphendula, ukuhlanza, ukukhishwa isisu, nokuncipha kwegazi glucose, ukujuluka yanda, izinguquko urinalysis.

Izixwayiso

Kwezinye izimo, kufanele kuthathwe nge ngokwedlulele ngokuqapha izidakamizwa "Eufillin"? ochwepheshe lezivakashi abonisa ukuthi izidakamizwa kumele kusetshenziswe ku-kadokotela futhi ngokuqinile ngaphansi kweso nje, ikakhulukazi uma isiguli ngumkhuhlane odabuka ongaziwa. Ngokucophelela okukhulu kumele kuthathwe imithi asebekhulile.

Kufanele kuqashelwe ukuthi izidakamizwa "Eufillin" bakwazi ukwandisa amazinga uric acid e umchamo. Phakathi isicelo se-nomuthi kumelwe siqaphele ikakhulukazi nokusetshenziswa kanyekanye esiningi ukudla neziphuzo caffeine.

Ngaphambi ekuphathweni parenteral ka ikhambi izidakamizwa Kunconywa ukuba ukufuthelana lokushisa komzimba.

izidakamizwa ekuhlanganyeleni

• Ngekusetjentiswa kanyekanye nale imithi kakhulu sithuthukiswe imiphumela bronchodilatory "Salbutamol" futhi "Terbutaline".
• ukwelashwa kanye kanye ne izidakamizwa "Eufillin", intengo zazo ingeqi ruble 40 isiRashiya, beta-blocker kungase kube lula angabacwasi ukubangela bronchospasm.
• Phakathi isicelo izimali kumele kukhunjulwe ukuthi umphumela wawo kakhudlwana uma ngesikhathi esifanayo ukuze afeze ngemithi ezifana "Erythromycin" futhi "cimetidine", kanye ukwakheka wokugoma Umkhuhlane futhi basebenzise izinto zokuvimbela inzalo ngomlomo.
• Izinga lokuhlushwa izimali egazini uwela ngenkathi ukusetshenziswa kwezidakamizwa "Carbamazepine", "rifamycins" futhi "Phenytoin".