Analogue of Plavix.

Omunye kuhlanganiswe yokwelapha antiplatelet buyisidakamizwa, "Plavix". Namuhla futhi ivame kakhulu kusetshenziswa imithi, njenge-Analogue of Plavix zilt. Ukwakheka izidakamizwa kuhlanganisa kokubili clopidogrel futhi acetylsalicylic acid. Isenzo oyinhloko ukulungiswa ezithaka imithi siqondiswe okusithiyayo of Adp-yokwamukela obangela wokuhlanganisa kwamangqamuzana egazi (e-platelet ethile). A lolwehlukanisa ukulungiswa awushintsheki esibophezelayo ka Adp-receptor, okuholela umphumela abasimeme wokuhlanganisa. Ngenxa yalokho womsebenzi yokwamukela kubuyiselwa kuphela kokufa ubudala futhi synthesis platelet entsha. Njalo is isakhiwo kanye mshini wezenzo we Analogue of Plavix - zilta.

Clopidogrel (Plavix Analogue) isetshenziswa umthamo 75 angu. Ngosuku lokuqala ngokuthatha izidakamizwa yabonisa attenuation abalulekile womsebenzi platelet wokuhlanganisa. Lapho isicelo esifakiwe ye inyuka izidakamizwa umphumela. Ihora ukulungiselela Cycle ezithaka imithi yisilinganiso sesifundo izinsuku ezintathu kuya kweziyisikhombisa. Ngemva ukuqedwa umphumela izidakamizwa it is waphawula (hhayi olusha ngokugcwele kuze iningi Ukwakheka platelet) ukuze uthole enye i esiyizinsuku eziyisihlanu kuya kweziyisikhombisa.

Salicylic acid kubangela okusithiyayo of platelet wokuhlanganisa ngenxa okusithiyayo engelapheki ka cyclooxygenase (Cox-1). Ngenxa yalokho, encishisiwe thromboxane zamagama kanye vasoconstriction attenuated. Njengoba esimweni clopidogrel umphumela eyenga inakekelwa phezu ukuphila wamangqamuzana egazi (izinhlayiya zegazi).

Kungani usebenzisa i-Analogue of Plavix kanye izidakamizwa ngokwayo? Ukusetshenziswa ezivame kakhulu ukwelapha ngenhlanganisela antiplatelet ulungisiswa zisengozini enkulu yokuba lesi thrombosis semithambo kwanoma iyiphi indawo ebukhoneni izilonda atherosclerotic.

Kukhona omunye Analogue ngaphezulu ezidumile Plavix - listab. Nokho, kwakhe, njengabanye abaningi (klopilet, lopirel, plargil, detromb, plogrel, Trocken, kardutol), akukhulunywa kabanzi kwezokwelapha zanamuhla.

Plavix noma zilt?

Odokotela abaningi elincike maqondana nokusetshenziswa Plavix, kusukela ukusebenza yayo iye kwafakazelwa izilingo olwenziwa. isizinda Ubufakazi izidakamizwa eseke emuva ngo-2007 futhi eminyakeni emihlanu edlule, i-azosebenzisa kwasicinisa isihloko "umkhiqizo best". Kepha zilta, nokusebenza ngendlela, njengoba kwaphawula u-odokotela ngokwabo, ngandlela-thile aphansi ukwedlula limenyezelwe, ngakho uma kuqhathaniswa sabafowabo maqondana izinga lokwelashwa akakwazi. Ngokuyinhloko, ososayensi bakholelwa ukuthi kahle ongaphakeme wale mithandazo kungenxa ukungapheleli inqubo zobuchwepheshe yokukhiqiza izidakamizwa. Biophysics esifanayo uqaphele ezinye iphutha e ukwakheka kwama-molecule phakathi Plavix kanye Analogue yayo.

Ngokuqondene intengo, kungcono kakhulu ilahlekelwa Plavix ziltu. Ngakho, intengo yokuqala kathathu ukubaluleka yesibili. Ezimweni eziningi, izindleko zomuthi kuholela isidingo ukusebenzisa nozakwabo ukungasebenzi kahle. On kwalezi ziqinisekiso odokotela emitholampilo yesimanje, uma ungakwazi ukuthenga Plavix ezibizayo akufanele ukuthenga Analogue eshibhile yalo - zilt. Ngokuphelele ukulahla yokwamukelwa zomuthi is hhayi Kunconywa.

Ngenxa izidakamizwa ezifana "Ko Plavix," khona-ke litshwayo sokuphuza isilinganiso esengeziwe somuthi anda ingxenye izingxenye (100 75 mg salicylic acid, futhi clopidogrel, ngokulandelana).

Ngeshwa, kuze kube manje yokukhiqiza ubuchwepheshe "Plavix" nomuthi, kanye izingxenye zalo abamelwe abasakwazi eqolo, okuholela Izindleko eziphezulu zokuthola izidingo imithi. Inzuzo ukusiza iziguli abami ukuza analogue ezinhle kakhulu kwemithi efuze.