Umuthi 'Buserelin Long "kuyinto analogue zokwenziwa of hormone zemvelo GnRH. Ukusebenza leli thuluzi yokuncintisana ngqo sesibopho ukuthobisa receptor amangqamuzana pituitary futhi okwalandela ukwanda lezivakashi emazingeni ucansi kwezidakamizwa plasma okwagcina kuphumela ukuvaleka ephelele okuthiwa gonadotropic pituitary umsebenzi. Ngenxa yalokho umuthi "Buserelin Long" inikezwa abacindezela ngqo i-hormone zamagama e-gonads, esizibonakalisa njengoba ukwehla kwamazinga testosterone (indices okuthumela-castration) e amadoda futhi ukunciphisa igazi estradiol okuthumela-menopausal izici ezigulini zesifazane. Esimweni sokuqala, singakhuluma castration kwemithi, okwesibili - ku postmenopausal noma ovariectomy.
Umuthi kukhishelwa ngomzuzwana njengoba lyophilizate elakhelwe ukulungiselela slurry. Ukwakheka lokhu nokulungiselela njengoba isici core kuhlanganisa mayelana 4 mg buserelin acetate. izingxenye Asizayo zihlanganisa sodium carmellose, a copolymer ka glycolic futhi dl-acidosis acid, polysorbate-80 d-mannitol.
Ngokuphathelene ukusetshenziswa kwezidakamizwa, i-ejenti esimisiwe 'Buserelin Long "ekwelapheni umdlavuza webele futhi ama-hormone engaphansi umdlavuza wendlala. Ngaphezu kwalokho, lokhu izidakamizwa angasetshenziswa ngesikhathi ekwelapheni i-endometriosis. Ukuze ekwelapheni lesizalo fibroids kanye nenzalo (ngokusebenzisa uhlelo IVF) futhi kufanele kuqale ukusebenzisa izidakamizwa "Buserelin-Long". Izibuyekezo odokotela afakaze imiphumela emihle yokusetshenziswa kwawo ekwelapheni izinqubo endometrial hyperplastic.
Uma sikhuluma Izimo eziyinhloko ukusetshenziswa, bese usebenzisa le imithi ngokuqinile contraindicated kubantu nge ukungabekezelelani ngabanye ukuba buserelin acetate, kanye nanoma yimuphi omunye izingxenye zayo asekelayo. Ngaphezu kwalokho, Izimo zihlanganisa nokukhulelwa kanye lactation.
Endaweni ehlukile, kufanele ishiwo imiphumela engemihle engase ibe ukusetshenziswa kwezimali "Buserelin-Long", njengoba kungaba, isibonelo, imbangela urticaria, edema angioneurotic futhi hyperemia. Ngaphezu kwalokho, kungase kube nezimo ezifana demineralization, ubuthongo thuthuva, ikhanda kanye nokucindezeleka. In iziguli zesifazane ukuzwa ubuhlungu besisu, izinguquko libido, ukujuluka yanda, menstrualnopodobnye ukopha bese we mucosa sowesifazane sangasese ngenxa ukusetshenziswa zokwenziwa izidakamizwa "Buserelin-Long". Imiphumela engemihle ezingabantu ngokuyinhloko elihlobene ne-exacerbation yesifo eziyimbangela, nokugcinwa urinary, gynecomastia, futhi "izinso ukuvuvukala." Ngaphezu kwalokho, kungaba imakwe ukwehla potency, ukujuluka yanda, ukuba buthakathaka kwezicubu e emikhawulweni bone ubuhlungu. Idlanzana iziguli zingase sithola ukusabela ezifana iziyaluyalu sohudo , futhi embolism yamaphaphu.