Umuthi 'Buserelin'. Izibuyekezo. Izinkomba, side effects

Umuthi 'Buserelin "libhekisela isigaba anticancer kwama-hormone i-hormone abantu abamelene nani.

Umuthi kuboniswa ngenxa ama-hormone engaphansi umdlavuza wesinye esigabeni sesithathu nesesine (uma kunesidingo deceleration testosterone ku testes). Ngo umdlavuza, le nezindlala mammary e insikazi umjikelezo wokuya esikhathini nge khona elondolozwe progesterone yokwamukela kanye / estradiol esabelwa futhi imithi "Buserelin". ochwepheshe lezivakashi zisikisela ukuthi izidakamizwa iphumelela kakhulu pathologies ama-hormone engaphansi we giperestrogeniey ezihlobene uhlelo zokuzala (isihlobo noma ngokuphelele). Lezi zifo zihlanganisa, ngokukhethekile, izinqubo hyperplastic endomentrii, kwesibeletho myoma, i-endometriosis. Medicine "Buserelin" (izibuyekezo namazwana reproductologists siliqinisekise) kufanele usetshenziselwe lokungeniswa nge-ovulation lihambisana gonadotropins ekwelapheni ukungabi nenzalo e-IVF (ngaphandle kwesibeletho fertilization).

Ukulungiswa senzelwe ongama, esicutshini futhi intranasal (ku acinene ingaphakathi) ekuphathweni.

Lapho ama-hormone somdlavuza Isikali wendlala indlala Kunconywa kusho "Buserelin" (izimpendulo wezazi bamunye ngalolu daba) ngemva kokuphathwa esicutshini kuyinto 3,75 angu esisodwa. Umjovo Kwenziwa njalo emavikini amane. Umuthi ingasatshenziswa phansi kwesikhumba kathathu ngosuku, 0.5 mg ngeviki. Emva isiguli idluliswe yokulungiswa intranasal isicelo ekulungisweni "Buserelin" (fafaza). ochwepheshe lezivakashi aveze ukuthi njengoba umthamo yesondlo eyanele 0.9-1.2 angu ngosuku. Inani zomuthi Kunconywa ahlukaniswe abe ngemithamo ezine.

Ngo webele umdlavuza iqondiswa 0.9 mg, ihlukaniswe izicelo ezintathu, intranasally.

Lapho Hyperplasia endometrial, i-endometriosis, lesizalo myoma eyenziwa imijovo esicutshini at umthamo we 3,75 mg njalo emavikini amane. Ubude besikhathi sokwelashwa - amasonto amane kuya kwayisithupha. Lesizalo myoma ubude bokusebenzisa izidakamizwa "Buserelin" (ukubuyekezwa odokotela uqinisekise lesi) kufika ku ukusebenza - izinyanga ezintathu, noma ukwelashwa ngoludala - ezinyangeni eziyisithupha. Ukusebenzisa izidakamizwa uqale ezinsukwini ezinhlanu zokuqala umjikelezo. Umthamo ukusetshenziswa intranasal - 0.9 mg ngosuku. Hlukanisa umthamo wansuku zonke kufanele kube ezintathu-emhlanjini. Ukwelashwa nge ekuqaleni ngosuku lokuqala noma lwesibili lomjikelezo. Isikhathi Ukuvikelwa fafaza "Buserelin" - izinyanga angaphezu kwayisithupha (ngenxa ingozi kwamathambo).

Umuthi akuvunyelwe ukusetshenziswa uma hypersensitivity.

Phakathi zokwelapha umuntu angezwa imiphumela engathandeki. Lapho iqondiswa intranasally engabangela wezakhiwo. Umuthi kungabangela thuthuva ubuthongo, ukucindezeleka, kwemizwelo lability, yokucasuka amehlo (uma usebenzisa ama-lenses). Lapho ebonisa indlela lo isidakamizwa ukuhlanza, ukucanuzela kwenhliziyo, ubuhlungu besisu, inhliziyo emnyama, inhliziyo neziyaluyalu, kwehle libido. Ngaphezu kwalokho, kungase ukuthuthukisa ubuthakathaka, kome sangasese, ukopha (menstrualnopodobnoe), isimila wesibeletho. imiphumela emibi zihlanganisa angioedema, ukucasuka kwekhala, siwasebenzise, isifuba, induna, ukujuluka anda. Kwezinye izimo kungase kube gynecomastia, ithambo demineralization, ukuvuvukala imilenze ephansi futhi izinyawo, thrombosis. Cishe ukuthuthukisa ukusabela ephathelene ne-testosterone zandiswe igazi ekuqaleni ukwelashwa (bone ubuhlungu, ukuba ndikindiki noma ukushoshozela ezinyaweni noma izandla, ubuthaka imilenze).

Kuyadingeka ukuba ngakususi nokukhulelwa kanye nezindlela zokuvimbela temlomo ukukhansela ngaphambi ukusetshenziswa kwezidakamizwa "Buserelin". Eyokuqala izinyanga ezimbili ekwelapheni fibroids kwesibeletho, Hyperplasia endometrial futhi endometriosis zesifazane isithiyo zokuvimbela inzalo yanconywa.

ukusetshenziswa okuqhubekayo zomuthi "Buserelin-Long" (ukubuyekezwa odokotela basikisela ke) amasonto amabili kuya kwamathathu kuholela ukwehla kwamazinga testosterone amadoda ukuba "postcastration amagugu".