"Kordinik": yokusetshenziswa, analogs kanye nokubuyekeza

izidakamizwa Antianginal ngokuthi izidakamizwa ukuthi ukwandisa igazi ligeleze liye enhliziyweni, kanye nokunciphisa-mpilo yayo funa. Le mishanguzo ngokuvamile esetshenziselwa impumuzo noma nokuvinjelwa ukuhlaselwa angina.

Angina - isifo esibonakala by ubuhlungu noma ukungaphatheki ngemuva breastbone. Ngokuvamile, ubuhlungu leso sifo kubonakala ngokuzumayo ucindezelekile ngokomzwelo noma usebenzise ukucindezeleka, futhi ngemva ukusetshenziswa ukudla. Ngokuvamile-ke kunikeza entanyeni, ingalo kwesokunxele, phakathi izindwani ehlombe, umhlathi ongezansi washiya esifundeni subscapular. emizweni okunjalo ezingemnandi luzophela phezu ¼ ihora. Futhi, ubuhlungu ubalekela emva ukumisa umsebenzi noma ngemva kokuthatha izidakamizwa anti-anginal. Njengoba yokugcina ngokuvamile kakhulu esetshenziswa imithi "Kordinik". Yokusetshenziswa, incazelo nokulungiselela impahla yayo ethulwa ngezansi.

Incazelo umkhiqizo okwelapha, injalo, ukwakheka kanye nokupakisha

Yini fomu esivela nomuthi "Kordinik"? Imiyalelo isicelo ibonisa ukuthi izidakamizwa itholakala ifomu tablet. Sinenkosi ifomu ploskotsilindricheskoy, abe mhlophe noma umbala eyethile lemicu empunga elinamathela othini-aphuzi.

Ukwakheka izidakamizwa ngaphansi ukucatshangelwa zihlanganisa nicorandil. Njengoba izingxenye asizayo esetshenziswa amazambane isitashi, i-calcium stearate futhi microcrystalline cellulose.

Ukudayiswa kwezidakamizwa "Kordinik" yokusetshenziswa Agcwele inqwaba amakhadibhodi ingena amaseli nentaba.

yezemithi nomuthi

Kuyini izidakamizwa emangalisayo "Kordinik" (amaphilisi)? Yokusetshenziswa ubonisa ukuthi nicorandil kunemiphumela antianginal. Kusekelwe inhlanganisela nitratopodobnyh izakhiwo, kanye nekhono ukuvula iziteshi potassium. Ngenxa impahla yokugcina izidakamizwa kubangela hyperpolarization we ulwelwesi cell.

umphumela Nitratopodobny lokhu imithi ukwandisa okuqukethwe guanilmonofosfata eyindilinga intracellularly. imiphumela enjalo kwemithi ukukhuthaza ukuphumula kwemisipha bushelelezi futhi bavikele myocardium ngesikhathi ischemia.

Ngokuphathelene imiphumela hemodynamic, basuke obonakaliswe ukuncipha olinganiselayo okuthunyelwe-futhi Layisha. Sikhishwe vasodilation (abakhethayo) nemithambo yegazi yenhliziyo e ischemic myocardium umthwalo lincishisiwe.

Nicorandil akunamthelela contractility esivimba amanzi. Ngaphezu kwalokho, lokhu izidakamizwa asishintshi kwenhliziyo. Nokho, kunciphisa letindzala blood pressure, futhi Ubuye Kusizuzisa engqondweni ukugeleza kwegazi kubantu unhlangothi ischemic.

Yini izakhiwo nezinye esivela izidakamizwa "Kordinik"? Yokusetshenziswa (izidakamizwa analogue ezibalwe ngezansi) uthi nicorandil akunamthelela umzimba ne-glucose lipid umzimba. He dambisa angina, futhi kunciphisa ubuhlungu imizuzu eziyisikhombisa ngemuva abaphathi ngaphansi kolimi. Qedela nokuqedwa ukungakhululeki waphawula kamuva ¼ amahora.

Kinetics kwezimali

Indawo ugxile izidakamizwa "Kordinik"? Yokusetshenziswa ubonisa ukuthi ukumuncwa zomuthi olucutshungulwayo livela ipheshana wokugaya ukudla. It ifinyelela isiqongo sayo lokuhlushwa plasma emva kwemizuzu 35-60.

Nicorandil kancane kuphela eboshiwe plasma amaprotheni. ingxenyenamba wayo khulula egazini 75%.

Lesi sidakamizwa is hhayi obala ukuze umzimba olunzulu esibindini. Ubizwa excreted ngu izinso kungakapheli imizuzu 50.

Izinkomba yokwamukelwa

Kunini lapho kufanele ngithinte ukusebenzisa amaphilisi "Kordinik"? Manual ithi lokhu kusho ezinhle kuzibonakalisa nge:

• nokuvimbela unhlangothi (ezinzile) lihambisana namanye izidakamizwa antianginal;
• Isithombe esiqoshiwe angina;
• monotherapy uma ukungabekezelelani BCCI ne-beta-blocker.

Izimo kokuthola

Lapho izibhebhe akufanele iqondiswa "Kordinik"? Yokusetshenziswa (omqondofana umkhiqizo okukhulunywa tibalwe lapha ngentasi) elikushoyo Izimo ezinjalo, njenge:

• nciphisa, ukushaqeka cardiogenic;
• AV-block of the wesithathu futhi besigaba sesibili;
• acute isilethikusebenza, futhi izinsuku ezingu-90 ngemuva kwalokho;
• angina engazinzile ;
• Okungalapheki senhliziyo (ekilasini lesithathu noma lesine NYHA ngezigaba obusebenzayo);
• hypotension lwemithambo;
• ngesikhathi sokukhulelwa;
• bradycardia;
• lactation;
• kwesokunxele ventricular esingamahlalakhona encishisiwe ingcindezi ukugcwaliswa;
• yobudala ezincane;
• Ukusetshenziswa ngesikhathi esisodwa phosphodiesterase-5 inhibitors (isib, "Sildenafil", "Vardenafil" noma "tadalafil");
• hypersensitivity emuthini.

Okumele kuqashelwe izibhebhe ezinjalo engabelwe kona inhliziyo isigqi neziyaluyalu, Prinzmetal angina, AV-nokuvinjelwa ngezinga lokuqala, hypotension, kahle isibindi umsebenzi nezinso hypovolemia, edema yamaphaphu, hyperkalemia, engela-Ukuvalwa glaucoma kanye igazi.

Izidakamizwa "Kordinik": Isikali kanye nokuphathwa

Tablets "Kordinik" Kumele kuthathwe ngomlomo, kungakhathaliseki ukudla.

Umthamo zomuthi ikhethwa ngamunye. Ngokujwayelekile, kuncike isikhathi nobukhali sifo.

Ukuze esiqoshiwe imithi angina ziphele lapho kuqubuka zokugula. Kulokhu iqondiswa ngendlela umthamo mg 20. I-Tablet ibekwe ngaphansi kolimi bese ubamba nje ancibilikisa.

Ngokuba nokuvimbela esitebeleni angina ukuhlaselwa (ezihlanganisa ukuvivinya eside) ngokuvamile izidakamizwa iqondiswa ngezilinganiso ka 10-20 mg kathathu ngosuku.

Umthamo esiphezulu zomuthi ngelanga kuyinto 80 mg. Ukuphathwa yikhanda umthamo kokuqala zingancishiswa.

side effects

Yini odinga ukukwazi ngaphambi kokuthatha izibhebhe "Kordinik"? Yokusetshenziswa uthi lokhu ejenti bangase baxabane enqabayo ezifana:

• ubuthakathaka, palpitations, ikhanda elibuhlungu, kunciphisa umfutho wegazi, isiyezi;
• tachycardia, tinnitus, "tide" kwegazi esikhunjeni, ukuqwasha;
• komzimba, edema neuropathy, isicanucanu;
• umuzwa ukugcwala esiswini, ukuhlanza, umsebenzi anda "isibindi" transaminases, ukungakhululeki besisu, stomatitis.

Ukweqisa izidakamizwa amaphilisi

Uma uthola inombolo enkulu amaphilisi isiguli izimpawu ezifana tachycardia nokwehlisa wawubona wegazi. Kulokhu, lesi sisulu wageza isisu, uyobanika isebenze namalahle. Futhi ukusekela umsebenzi yisimiso senhliziyo nemithambo yegazi.

Ukuxhumana nezinye izidakamizwa

izidakamizwa Antianginal olucutshungulwayo buyaqina lapho antidepressant, vasodilators, phosphodiesterase-5 inhibitor, antihypertensives, futhi tricyclic antidepressant. Kunjalo of isisu, mao inhibitor, beta-blocker futhi ethanol.

izincomo ezithile

Ikhansela izidakamizwa kufanele kube kancane kancane. Phakathi ukwelashwa kuyadingeka ukuqapha ECG kanye lwemithambo blood pressure, kanye okuqukethwe sodium ne-potassium ion egazini. Futhi, edonsa le imithi kungase kwandise arrhythmias inhliziyo.

Analogs futhi omqondofana zomuthi, izindleko zawo

Manje uyazi ukuthi umuthi "Kordinik". Yokusetshenziswa, izithombe kanye izakhiwo zomuthi aye ethulwa ngenhla.

Bangaki kubhekwe izidakamizwa izindleko? Njengomthetho, intengo amaphilisi ithuluzi 60 (10 mg) kuyinto ruble 450. Nakuba kwezinye izindawo ezweni lakithi, leli nani zingandiswa noma, kunalokho, kwehle.

Abadinga ahlekise imithi ungayithola enye by analogs ezifana "Dilasidom", "Korvamin", "Carbochromen", "Korvaton", "Sydnopharm", "Oxycardin", "Reasanz" nabanye.

Ngokuqondene omqondofana, umuthi kuphela "Coronel" isibaluli kuye.

imithi Izibuyekezo

Mayelana "Kordinik" izidakamizwa has a lot wokubuyekezwa okuvumelekile. Abathengi baphikisa ngokuthi ezifana ejenti antianginal ukubhekana ngokugcwele umsebenzi. Ukwemukelwa ithebhulethi okukhulunywe ngawo ngaphambili ngempumelelo ekunciphiseni angina, kanye aqede izinhlungu nokuphatheka kabi ngemuva breastbone.

Ngaphezu izinzuzo zalesi izidakamizwa ahlanganisa ukutholakala kwayo kanye nekhono esikhundleni kumakhophi, kanye nemibi - amanani entengo aphezulu futhi inqwaba ukusabela ezingezinhle.