"Formetin": yokusetshenziswa, ngempela

Okwamanje sathola abantu abaningi abanesifo sikashukela kanye ngenxa yezinkinga ezihambisana nokukhuluphala hlobo. izidakamizwa Abaningi etholakalayo ngoba impatho yalezi zifo. Omunye wabo ikhambi "Formetin". sezici zalo ezimangalisayo izochazwa lesi sihloko.

isigaba ezenza imithi

"Formetin" yokusetshenziswa okuyinto kuboniswe kulesi sihloko, kuyinto hypoglycemic izidakamizwa iqembu biguanide.

Incazelo ukwakheka kanye ukukhululwa ifomu

Kwelinye ithebhulethi yayo:

izidakamizwa Iyatholakala "Formetin" e amabhamuza 100, 60 noma amaphilisi 30.
Umbala White amaphilisi kanye ngomthamo ifomu incike impahla isizinda. Ngezinye 500 mg ploskotsilindricheskoy banayo umumo isiyingi nge uphawu kanye chamfered. Futhi umthamo 1000 mg noma 850 mg has "Formetin". Izibhebhe kuleli cala, convex kanye okweqanda. Ziyakwazi ingozi eyodwa emaceleni.

pharmacodynamics

Metformin ( "Formetin") siyehla gluconeogenesis ogeleza isibindi, futhi ngaleyo ndlela kukhona ukwehla glycogen awagcine. Leli thuluzi kunomthelela nobunzima ukumuncwa kusukela glucose emathunjini, ukuthuthukisa kokususwa amazinga kashukela egazini kohlelo. Lokhu kwandisa impendulo kwezicubu insulin ngaphandle ezithinta ukukhiqizwa endocrine yayo ingxenye kwamanyikwe B-amaseli, ngokudlula ukuphendula hypoglycemic, ngoba ayicushiwe ukukhiqizwa wathi izidakamizwa.

Izidakamizwa "Formetin" izibuyekezo ukhulume ukusebenza yayo, kunciphisa inani igazi "okubi" cholesterol ne-triglyceride. Okuqukethwe okusezingeni eliphezulu kwabantu lipoproteins lokhu kwandisa ukuba 20-30%. Nge ukwehluleka Ukudla izidakamizwa "Formetin" yokusetshenziswa elichazwa lesi sihloko kusiza ukunciphisa kanye / noma ekulinganiseni isisindo lesiguli. Lokhu kwenzeka ngenxa namachibi glucose ngu-mpilo-free futhi Zinciphisa isifiso. Futhi-ke imizwa izicubu plasminogen kusebenze inqubo ngokwenza inhibitor yayo, lapho umphumela hemostatic livela.

Pharmacokinetics

Nokwenziwa metformin iqala pheshana emathunjini. Inani esiphezulu ketshezi igazi imayelana 2.5 amahora emva isicelo ngesilinganiso iyunithi ukumuncwa umthamo - 50-60%. Ukuncela izinga izidakamizwa emzimbeni kuthinta ukuhlobana izidakamizwa esebenzayo kanye amaprotheni ku-plasma. Ngo amaphilisi "Formetina" akukho uxhumano plasma amaprotheni. It ukhuluma ekulenzeni libe namandla. Kusukela ezincane isici yokubopha izimvu, umuthi kangcono ugxile. Sebethule iyona izinso, isibindi, ezicutshini izicubu, e nezindlala salivary. Emzimbeni, metformin uhlala ingashintshiwe. Kamuva excreted ngu nezinso. Ngakho-ke, uma ukwephulwa yomsebenzi wabo siyenzeka ekuqongeleleni. Biological isigamu-ukuphila amahora 1.5-4.5.

phetho

Medicine "Formetin" lisetshenziswa ekwelapheni nezigaba ezithile izifo. Okungukuthi, ebukhoneni-type II sikashukela, nge izimo ukukhuluphala nge eziyinkimbinkimbi lapho ekudleni kungasizi ukugcina amazinga kashukela egazini evamile, ngisho lihambisana sulfonylurea. Futhi ngempumelelo iyona "Formetin" isisindo ukulahleka.

Indlela?

Umthamo udokotela usho ukuthini ukhetha, ngokusekelwe lemali glucose egazini. ekuphathweni Oral kuyadingeka ukuze usebenzise emva kokudla, aphuze nale esiningi uketshezi edalula machining ithebhulethi. Njengoba sekushiwo ngenhla, umthamo ezinqunyiwe kuncike okuqukethwe glucose egazini. Luqala ngokunikela inani eliphansi - 0.5 g noma 0.85 g ngosuku. Ngemva kwezinsuku ezimbili ukuqala ukwelashwa nale izidakamizwa kuye kwaba okuqukethwe okusimeme metformin egazini. Ngokukhethekile, kancane kancane umthamo kuze kube seqiwe. Kuyinto okulingana 3 amagremu.

Njengoba abadala sivame ukuba ukuthuthukiswa lactic acidosis, ngabo ezingeni umthamo sangemihla se-1 g nenani lomuthi nayo iyancishiswa ayephuli umzimba, ukuze kuvinjelwe ukusabela iguliswa, esizibonakalisa ngesimo ukuqubuka, kanye nezinye izenzakalo kungenzeka ezingezinhle, okuzokwenza icaciswe ngezansi.

Izimo

Kule ndaba, kukhona umehluko wemisindo nemiqondo yamagama amaningi. Izidakamizwa "Formetin" yokusetshenziswa olubonakaliswa kulombhalo, is contraindicated ebukhoneni:

• ketoacidosis Diabetic, precoma, equlekile.
• Sinzima kahle ukusebenza kwezinso.
• ukuhluleka senhliziyo futhi zokuphefumula.
• isigaba okukhulu isilethikusebenza.
• Ukuphelelwa amanzi emzimbeni.
• ukuluthwa utshwala ezingamahlalakhona kanye nezinye izimo ezingaba nomthelela ukubonakaliswa ekuthuthukiseni lactic acidosis.
• unhlangothi olunamandla.
• Bekhulelwe nangenkathi bencelisa.
• Hypersensitivity kule srudstvu.
• ukuhlinzwa okukhulu noma ukulimala, lapho insulin esimisiwe.
• izifo ezinzima ezithathelwanayo.
• iziyaluyalu Functional kwesibindi.
• Acute utshwala ubuthi.
• lactic acidosis (kuhlanganise umlando).
• Ukudla Hypocaloric (ngaphansi kuka-1000 kcal. Per ngosuku).
• Adioizotopnyh noma izifundo radiographic, ekuphathweni lomcebo iodide hlobo.

Futhi hhayi Kunconywa ukuba asebenzise izidakamizwa "Formetin" abantu phezu engamashumi ayisithupha, umsebenzi odinga amandla. Kusukela kulokhu, banezizathu sengozini enkulu yokuba lactic acidosis.

isicinganani

Okuvela ezifana izimpawu ezingemnandi njengoba "metallic 'banambithe emlonyeni, ukuhlanza, isicanucanu, uhudo, ukubuyisa, ukuntula isifiso sokudla kudinga ukuqedwa ukusetshenziswa ukwelashwa, nokudlulisela ngokushesha kudokotela onguchwepheshe. ukusetshenziswa eside zomuthi kuphazamisa noma ukumisa okuphelele edonsa Vitamin B _12, okuholela ekuqongeleleni emzimbeni wabo, okubangela Vitamin kwamaphutha. Ezimweni ezingavamile, ukuthuthukisa reverse - megaloblastic I _12-ayindlala igazi. Uma engafanele iqondiswa umthamo kungenzeka kahle kungakhuphula izinga likashukela. Ungase uthole nokuthi uba komzimba ezifana ukuqubuka kwesikhumba. Ngakho-ke, lesi sidakamizwa "Formetin" izibuyekezo ku nokufaneleka yayo ukusetshenziswa ezahlukene, kufanele aqokwe kuphela udokotela ukuba khona.

Izixwayiso

Isici esibalulekile kuchazwe zindlela ukugcina eziyisisekelo izidakamizwa "Formetina" emzimbeni futhi yalokhu.

Ukuvimbela ekuqongeleleni lactic acidosis kanye nokuvinjelwa metformin, kubalulekile ukuqapha izinkomba umsebenzi izinso futhi ukuhlolwa ukucacisa okuqukethwe acidosis acid emzimbeni okungenani izikhathi 2 ngonyaka. Futhi, uma une ubuhlungu bemisipha kufanele retested.

Umthelela wathi izidakamizwa ekhonweni ukushayela izindlela ukushayela izimoto

Kulokhu, njengoba kukhona umehluko wemisindo nemiqondo yamagama athile. Umthelela "ikhono Formetina 'ukuze besebenza ngemishini kanye ezokuthutha kwenzeka kuphela uma isetshenziswa ngesikhathi esifanayo ne izidakamizwa ezithinta izinqubo zokusebenza ezidinga ijubane izimpendulo zabo bese ukhulisa okuhlushwa. Kubalulekile ukwazi.

Isicelo bekhulelwe nangenkathi bencelisa

Ukulungiselela "Formetin", imiyalelo for ukusetshenziswa okuyinto echazwe lapha, kunemiphumela embungwini isigaba «B» ngu-FDA. Phakathi nenkathi yokukhulelwa bangathola le mali. Nokho, ukusetshenziswa kwalo kungaba kuphela ezimweni ezithile. Okungukuthi - uma imiphumela kulindeleke kusukela kule yokwelapha ziyoyidlula ukutholakala engaba ingozi embungwini. izifundo esiqondile icala ku ukusetshenziswa ithuluzi ezifana izidakamizwa "Formetin" lwenziwe ngesikhathi sokukhulelwa. Ngesikhathi sokwelashwa kufanele ayeke ibele. Kunoma ikuphi, udinga ukuthintana nodokotela oqeqeshiwe.

izidakamizwa ekuhlanganyeleni

Metformin kwandisa izinga likashukela egazini. Lokhu kubonakala ikakhulukazi ne reception ngesikhathi esisodwa non-steroidal izidakamizwa eqeda ukuvuvukala, nemikhiqizo sulfonylurea futhi clofibrate, monoamine oxidase inhibitor, acarbose, insulin, oxytetracycline, cyclophosphamide, inhibitor ka angiotensin ukuguqulela enzayimu blocker kanye nohlobo.

Lapho isicelo kanye endocrine izidakamizwa (zokuvimbela inzalo temlomo, corticosteroids, sympathomimetics epinephrine, ama-hormone egilo ndlala glucagon, thiazide futhi "loop" isisu, phenothiazine okunye, nicotinic acid ahlobene) Kungenzeka metformin hypoglycemic unyathela amabhuleki inqubo.

Nge inhlanganisela ithuluzi ezifana izidakamizwa "Formetin" nge "Tsimidinom" "nifedipine" ingozi elikhulayo lactic acidosis, metformin ezivimbela excretion kusuka emzimbeni. Okunjalo nasemkhakheni umsebenzi imikhiqizo oludakayo, e Umq. H. Ngo ukwakheka kwemithi.

ejenti Cationic (quinidine, amiloride, digoxin, procainamide, morphine, i-quinine, vancomycin, ranitidine, triamterene) kwakheka tubules, elwela nekambiso yeenthuthi nokwelashwa eside kungase kwandise izinga kwezidakamizwa lokuhlushwa kuya ku-60%.

ukweqisa izidakamizwa

Overdose "Formetinom" abona othile ewunikela ngesikhathi ethatha 0.85 amagremu ngosuku nokuvuselela lactic acidosis. Futhi, wokuqukethwe lelisetulu metformin ngenxa nokwehluleka ukusebenza kwezinso.

Izimpawu zokuqala lactic acidosis kukhona ubuthakathaka bomzimba wonke, ukuvuvukala, izinga lokushisa komzimba ongaphakeme, ubuhlungu esiswini kanye nemisipha, ephansi blood pressure, bradyarrhythmia reflex. Kwezinye izimo, lapho zenzo ziwukubonakaliswa njalo kuphazamiseka zokuphefumula, isiyezi, futhi, ngenxa yalokho, kukhona ukuthuthukiswa ikhoma.

Ngesikhathi kancane izimpawu ukweqisa izidakamizwa kufanele ayeke ukudla izidakamizwa futhi kudokotela ukuqinisekisa sitholakele lactic acidosis. Ukuze kususwe ketshezi esebenzayo ye-ejenti kanye acidosis acid esuka i umzimba ngeke hemodialysis parallel ukwelashwa lingaze.

"Formetin": nozakwabo

Kunezindlela eziningi imithombo yalolu hlobo. Analogue "Formetina" aphume ashone ukwakhiwa equkethe ukubunjwa yayo njengendlela Isakhi esiyinhloko metformin hydrochloride. Esinye isibonelo salokhu izidakamizwa abakhiqizi isiRashiya, "Vero Metformin," "Gliformin", "metformin", "Metformin-Richter", nakwamanye amazwe - "Glucophage", "Glucophage" futhi "Glyukofazh Long" (France), "Lanzherin "(Slovakia)" Metfogamma "nge imithamo lomcebo asebenzayo of 0,100, 0,500 futhi 0,850 g (eJalimane) obuhlukahlukene.

Imibandela kanye nemigomo

Kule ndaba, kukhona izimo ezithile. Ukulungiselela "Formetin" lungumbulali, ngakho-ke ikhishwe kuphela kadokotela futhi kudinga isitoreji ekamelweni lokushisa, ukuzamukela kwezingane kanye kwelanga indawo. Impilo-ke - iminyaka 2.

izindleko

Intengo isilinganiso ngokuba izidakamizwa "Formetin" kusethelwe kuncike umthamo ruble 59. 0.5 g we ibhamuza, ruble 133. ka 0.85 g futhi ruble 232. phezu ngonyaka 1

isiphetho

Zonke osekushiwo kuhlanganisa eziningi imininingwane ewusizo. Ngemva kokufunda lesi sihloko, wonke umuntu uyokwazi ukuthola impendulo yombuzo kanjani ukuthatha 'Formetin "futhi lokho izakhiwo.