Cromoglicic acid. Incazelo, izimpawu, contraindications

Uyini cromoglicic acid? Lokhu uzofunda kusukela izinto ezihambisana lesi sihloko. Siphinde ngikuxoxele okuyinto imithi aqukethe ketshezi wathi futhi limelela.

ifomu ukukhululwa, incazelo

Cromoglicic acid ikhiqizwa njengenhlangano aerosol ngoba lapho ephefumula, spray acinene, iso amaconsi futhi acinene spray. Futhi leli thuluzi angathengwa ngesimo isixazululo kucace futhi amaphilisi nge powder, senzelwe ephefumula.

Umgomo we operation ye nomuthi

Cromoglicic acid, intengo oboniswe ngezansi, kuzole insika cell ulwelwesi, kanye zithutha yabo. Lokhu kungenxa nokuvinjelwa kwe-calcium engena amaseli.

Kufanele kuqashelwe ukuthi le-ejenti kuvimbela ukukhululwa kwe yokungezwani komzimba balamuli ezifana leukotrienes, histamine, nezinye SG2, amangqamuzana ezahlukene, okuyizinto mucosa we Isikhala sayo esingaphakathi we bronchi kanye isihlahla bronchial. Ngaphezu kwalokho, lokhu izidakamizwa kusiza ukuvimbela yokufuduka monocytes futhi neutrophil.

izakhiwo

Cromoglicic acid kutshengisa Izakhiwo ezilandelayo:

• ngempumelelo kakhulu nokuvimbela uhlobo ngokushesha yokungezwani komzimba kubantu abasha, angakawamukeli uvele izinguquko ezingenakuhlehliswa okungalapheki wamaphaphu. Kufanele kuqashelwe ukuthi imfuyo wathi ongakawabelani athuthukile aqede bronchospasm.
• Imibukiso umphumela ulwelwesi-eliletha ukuthula. Uhlelo ezivimbela yamaphaphu impendulo umlamuleli sisiza ekuvimbeleni ukukhumuzeka impendulo ekuqaleni futhi isigaba ngasekupheleni somoya (kuhlanganise impendulo ezintweni somzimba sokuzivikela nezinye).
• umphumela Esitebeleni ukusetshenziswa imithi kufinyelelwa ngemva kwamasonto 2-4. Effect zomuthi ngemva kokuphathwa olulodwa lapho kuze kuphele amahora 5.
• Imiphumela lubonakale ukwelashwa yezifo iguliswa kwezitho ezibukwayo kwenzeka emva kwezinsuku ezimbalwa noma amasonto.

• ukusetshenziswa isikhathi eside zomuthi kunciphisa ukuvama ukuhlaselwa yesifuba somoya bronchial, futhi kusiza kakhulu amakhanda enkambweni yabo, kunciphisa isidingo ukuthatha corticosteroids futhi bronchodilators.

kinetics

Cromoglicic acid matasa kusukela ipheshana zokuphefumula e isamba ngo-10%, kuthi ngemva kokuba sekuvele ukuthi uhogele ka nomuthi powder kanye isixazululo - 5-15% futhi 8% ngokulandelana.

Ukuncela kusukela zokuphefumula nolwelwesi lwamafinyila incipha lapho inani uketshezi. Ubuningi esiphezulu we ketshezi kufinyelelwa ngemva ¼ ihora.

Leli thuluzi hhayi akheka. Its isigamu-ukuphila imizuzu 45-90 of. Lokukhipha ngokusebenzisa amathumbu izinso ngezabelo mayelana elinganayo, kanye ukudlula emaphashini.

Intranasal ekuphathweni lwalo emfudlaneni igazi uthola mayelana 7% we ekwakhiweni. Nge-plasma amaprotheni ke sibopha 65%. Lapho leli thuluzi is hhayi akheka futhi excreted ku Bile nezinso ngefomu ingashintshiwe kungakapheli amahora isigamu. Ingxenye ketshezi asebenzayo kugwinyiwe ngaphandle ukumuncwa futhi zabelwe ngu pheshana emathunjini.

ubufakazi

Drops ngoba amehlo Antiallergic zinikwa conjunctivitis nomzimba, keratitis nomzimba, keratoconjunctivitis, ezomile iso syndrome, ubunzima, ukukhathala le mucosa ukuluma kwamehlo izitho ezibukwayo ziyabagulisa.

Kufanele kuphawulwe ukuthi leli thuluzi isetshenziselwa nokuvimbela somoya bronchial, bronchospasm kanye ukucinana kwemithambo yomoya emaphashini ne BOS syndrome.

I umuthi ngesimo ejenti acinene Kunconywa hay fever kanye rhinitis iguliswa.

Izimo

izidakamizwa Okubukwe akukashicilelwa ngoba:

• hypersensitivity;
• sokukhulelwa (senyanga lokuqala uhogele i);
• ezinganeni (isikhathi esingaba iminyaka emibili - ngesimo powder kanye amaphilisi ngoba isixazululo ephefumula, oneminyaka engu-5 - ngesimo i aerosol ngoba ephefumula futhi intranasal abaphathi);
• ibele (i intranasal abaphathi).

Kromoglitsievoy acid: imfundo

Inhalation amaphilisi ngoba ephefumula kufanele kusetshenziswa spinhalera izikhathi 4 ngosuku ngezikhawu amahora 3-6 (20 mg).

Alinganisiwe umthamo ephefumula aerosol iqondiswa 1 umthamo (1 mg) kane ngosuku.

Isixazululo for inhalation Usebenzisa nesifutho esebenzisa (20 mg) kane ngosuku. Ngaphambi kokusebenzisa i-bottle kahle ezinyakaziswayo futhi igcinwe sesimweni uqotho.

Ikhala amathonsi zaphathwa abadala e ikhala ngalinye 3-4 lehla emahoreni angu-4-6, futhi izingane ezineminyaka engu-6 - njalo emahoreni 6 1-2 amathonsi. Ngemva ukubukeka umphumela oqabulayo isikhawu phakathi Ukweqiwa izidakamizwa kungase kwandise kancane kancane.

spray acinene isicelo 1 umthamo ngamunye acinene Yiqiniso 4-6 izikhathi ngosuku. Inkambo yokwelashwa singemaviki lange 4. Ukuqedwa zomuthi kumele kwenziwe kancane kancane phezu ngesonto elilodwa.

Eye amaconsi (isb, "Sodium cromoglycate") usebenzisa 1-2 lehla esweni ngalinye kane ngalinye emzimbeni usuku nge esingaba amahora 4-6. Uma kudingeka, inani lakhuphuka lafika ku instillation of 6-8 amathonsi.

side effects

Isihloko kungadala:

• isiyezi, isicanucanu umongozima;
• ukucasuka koma emphinjeni, ubuhlungu bekhanda, nomlomo owomile, nokugcinwa urinary;
• ukucasuka zokuphefumula, ukucinana acinene, ukukhwehlela, evuthayo amehlo, kahle izinso umsebenzi, uketshezi anda uketshezi acinene;
• ukuqubuka kwesikhumba, edema conjunctival, izinyembezi, ezingemnandi ukunambitheka ukuzwa, angaphandle umzimba ukuzwa, ibhali, lacrimation;
• anaphylaxis (kuhlanganise nobunzima ukugwinya, isikhumba silume, elisetshenziswa iqhude, isifuba ukuvuvukala izindebe, ubuso nezinkophe, ukwehlisa umfutho wegazi, iphika).

Bomcondvofana kanye inani lentengo lomuthi

Kungaphansi kwaziphi egameni lendawo yokuhweba noma ithengiswe kromoglitsievoy acid? Lokhu "Ditek", "i-sodium cromolyn," "Ifiral", "Intal", "kromogeksal", "Kromogen Easi-Breathe", "Nalkrom", "Kromogen", "Kromoglin", "Kromosol", "Cromolyn", "Kropoz "" Lekrolin "," Kuzikrom "," Stadaglitsin "," Hi-chrome ".

Intengo izindlela zingase zihluke, kuye ngokuthi umenzi, uhlobo umuthi namaphesenti inethiwekhi ekhemisi. Nokho, ngokwesilinganiso izindleko kromoglitsievoy acid ruble 100-250.