Antivirals

Imithi elwa namagciwane - izidakamizwa ukuthi isinyathelo amagciwane ngokucekela phansi izakhiwo zabo noma sokuphazamiseka kwengqondo kubalulekile imisebenzi.

Okwamanje itfutfukise eyanele izidakamizwa ezinjalo. Bonke ihlukaniswa izici izenzo kwemithi futhi izinkomba ezithile zokwelapha. Ukwabela iqembu elandelayo ejenti elwa namagciwane: ukusabalala spectrum antiherpethetical, protivotsitomegalovirusnye, umkhuhlane, anti-retroviral. Laba bameleli be-esaziwa kakhulu uhlobo lokuqala mithi "ribavirin" futhi "lamivudine". Le mithi kufanele izakhi eziyinkimbinkimbi isinyathelo, ezihlobene ukuncishiswa of acid nucleic ngu sesibopho ukuthobisa enzyme igciwane. Njengoba igama emkhakheni ukusetshenziswa kwalezi izidakamizwa ngempela ibanzi futhi ihlanganisa eziningi DNA - futhi i-RNA-equkethe amagciwane ezibangela PC Syndrome, imfiva Lasa, isifo sokusha kwesibindi kohlobo C, kanye ne-AIDS.

izidakamizwa Antiherpethetical amelwa izimali amane, okuyinto by yabo isakhiwo morphological analog nucleoside acyclovir, penciclovir, famciclovir, valacyclovir. I last amafomu amabili Isikali abapholile. Kubantu, basuke iguqulwe ukuze acyclovir futhi penciclovir. Lokhu kubangela izakhiwo zabo bethuthumela morphological kanye histological.

Lo mshini wezenzo ka acyclovir ungaphakathi ukuxhumana ne enzyme viral whereupon iphazamisa umjikelezo yabo nentuthuko. Umphumela lapho kubhujiswa lesi lwegciwane. Lokhu kusebenzelana bunikezwa isakhiwo acyclovir, esiwumfanekiso dezoksiguanedina analog (purine nucleoside). Iningi ebucayi emuthini iyona igciwane herpes simplex. Kukhona zakulezi nezilwanyana ezincane lapho amelana lokhu izidakamizwa. Lo mphumela zingachazwa ngezinqubo ukusetshenziswa ukwelashwa immunosuppressive. Mshini yokumelana iyona ngokuguqula izakhi izinhlelo igciwane enzyme, ukushintsha ngokucacile zomuthi. Esimeni izimo ezinjalo yizidakamizwa bezinye kwemithi ( "Foscarnet"). Izingane antivirals zihlanganisa "Valacyclovir." bioavailability High, olunamanzi angamaphesenti angu-ezingaphezu kwamashumi amahlanu yezimbangela nomphumela ofanayo. Lokhu kusho ukuthi-ke kudinga ngemithamo ezincane kakhulu izidakamizwa (uma iqhathaniswa 'Acyclovir ") ukufeza umphumela.

Lo mshini wezenzo ka penciclovir nhlobo ezahlukene kusukela amalungiselelo eqembu. Iphinde kwephula DNKmikroorganizma zamagama. Nokho, uyahluka ngokuthi ngokuyinhloko kuthinta igciwane Varicella-Zoster (VZV).

Ngu protivomegalovirusnym izidakamizwa zihlanganisa "Ganciclovir", "Valganciclovir", "Foscarnet", "Cidofovir", "Fomiversen". Sinenkosi indlela kunalokho eyinkimbinkimbi yama isinyathelo, okubandakanya okusithiyayo ukuncintisana emkhakheni polymerase DNA lesi silwanyana. Waba yini umphumela walesi nokuxhumana kuyinto komthetho zobude yochungechunge DNA eholela ekufeni yayo. izidakamizwa Iningi namagciwane ezikhipha izimpawu cytomegalovirus ukutheleleka - kusho leli qembu kwemithi. Nokho, ukusetshenziswa emva nokunwetshiwe ka yokumelana nomuthi angagcina, okuyinto kancane kunciphisa uhla lokusentshenziswa yabo.

Imithi elwa namagciwane ingaba nethonya eliqondile phezu human immunodeficiency virus. Ngakho-ke, abanye yasekhemisi, okuyinto has a action efanayo, kuhlangene iqembu ngezidambisigciwane. Bonke babe indlela eyinkimbinkimbi isinyathelo lihlotshaniswa ukuvaleka enzyme izinhlelo umzimba, ukufanisana yayo ukuhlukumeza.