Medicine "Tamoxifen" umyalelo ku isicelo siphathelene neqembu izidakamizwa antineoplastic ne umphumela nonsteroidal futhi antiestrogenic. Ukusebenzisa le-ejenti kuvusa ukukhishwa kwama-hormone pituitary kunciphisa ukuvuvukala nangempumelelo Kumiswe ukuthuthukiswa neoplasms. Kusukela ngo-lokuqala eyamukelayo izidakamizwa amabhlogo isenzo estrogen amasonto ambalwa, ngaphandle kokudala engathandeki side effects elihlobene ne overgrowth ihlule. In iziguli owesilisa abaphethwe ejaculation sifo, ukusetshenziswa "Tamoxifen" kungase kuvuse ukwanda plasma testosterone lokuhlala. Uma sihlola pharmacokinetics ye-ejenti anti-isimila, uqala ukuba abakhuthele emva imizuzu engamashumi amathathu nje ngemva kokuphathwa, ukufinyelela eliphakeme e amahora eziyisihlanu kuya kweziyisikhombisa.
izidakamizwa Iyatholakala "Tamoxifen" ngefomu ithebhulethi ophuzi, equkethe njengoba ingxenye main angu eziyishumi, ezingamashumi amabili, amathathu noma amane tamoxifen citrate. izithako Eminye yilezi: i-cellulose, sodium isitashi, magnesium stearate, lactose futhi povidone. Igobolondo iqukethe ukubunjwa polyethylene glycol yayo, ama-titanium dioxide futhi hypromellose. Ngaphezu kwalokho, inani elincane samanje lactose izidakamizwa.
Yabela amaphilisi "Tamoxifen" imfundo manual incoma ukuthi iziguli ezine- umdlavuza endometrial, wendlala noma amaqanda, futhi thoracic nezindlala mammary. Futhi, lo muthi siyasebenza kakhulu for izimila e izinso noma melanoma. Sarcoma kufana ukuqala ukuthatha izidakamizwa "tamoxifen". Yokusetshenziswa amanothi kanye nemiphumela emihle elisetshenziswa ekwelapheni zokwakheka etiologies ehlukahlukene uzlovidnyh.
Thatha le-ejenti antitumor akuvunyelwe nakancane endabeni ukungabekezelelani ngazinye citrate tamoxifen noma yimuphi omunye izingxenye izidakamizwa. Leukopenia, thrombophlebitis, ukukhulelwa, inkathi lactation, lolu ngwengwezi namafomu ezinzima yesifo senhliziyo futhi Izimo kule izidakamizwa, "Tamoxifen" - yokusetshenziswa unaka ke. Ngaphezu kwalokho, musa ukuthatha ke iziguli esingamahlalakhona hepatic noma kwezinso. Ngokukhulu ukucophelela ukhombe iphilisi "Tamoxifen" nge thrombocytosis, thrombocytopenia, izifo zobuchopho, noma hypercalcemia.
Lesi sidakamizwa kwezinye amaqembu iziguli kungabangela ukuqunjelwa, isicanucanu, ukuhlanza, cholestasis, kwehle esesuthi, ukukhishwa yisisu kanye nokuba kokuziphatha kwesibindi. Ukudideka, thrombocytopenia, ikhanda elibuhlungu, leukopenia, ukozela, imfiva kanye nesiyezi futhi kungenzeka ngenxa ukuthatha amaphilisi, "Tamoxifen". Imiphumela engemihle zihlanganisa, futhi ingozi lesizalo ukopha, ukushiswa nokuphangwa ukulunywa e izitho zobulili, izimila fibrosis, urticaria, dermatitis kanye bronchospasm. Ngaphandle kungaba ukwehla waphawula e potency, khulula lwesitho sangasese sowesifazane, ukuqubuka kwesikhumba futhi ububomvu.