Umuthi 'Betagestin "kusukela inzululwane. "Betahistine": yokusetshenziswa, intengo, ukubuyekezwa

enza lesi sidakamizwa "Betahistine" (amaphilisi) Kanjani? Yokusetshenziswa, ukubuyekezwa, izincazelo kanye izakhiwo zomuthi ethulwa ngezansi. Ngaphezu kwalokho, sizokutshela ngalokho ithuluzi inikezwe, ukuthi kubiza malini, uma unanoma yimiphi imiphumela emibi kanye contraindications.

Ukwakheka, incazelo ukuma

Khipha ifomu zomuthi kwelinye - amaphilisi. Noma kunjalo, ayatholakala nge amanani we ketshezi esebenzayo obuhlukahlukene:

• Valium amaphilisi ezimhlophe ukuma isiyingi esinelebuli ngemithamo isithako esisebenzayo (betahistine dihydrochloride) - 8 mg.
• ithebhulethi oblong futhi biconvex nge amazinga okukhishwa imiphetho oyindilinga esinelebuli isithako esisebenzayo (betahistine dihydrochloride) - 16 noma 24 mg.

Njengoba izithako asizayo idatha ukuma aqukethe sodium lauryl sulfate, i-sodium croscarmellose, microcrystalline cellulose, magnesium stearate kanye citric acid.

Isenzo kwemithi zomuthi

Uyini izidakamizwa "Betahistine?" Yokusetshenziswa (intengo nemithi ezibalwe ngezansi) ibika ukuthi izidakamizwa kuyinto Analogue of histamine, obadalwa synthetically.

Active amaphilisi isithako uyakwazi ehilela histamine H-3 futhi H-1 receptor (eqinile futhi abamelene ababuthakathaka) CNS (ngamanye amazwi, ama-receptor we nuclei vestibular nezindlebe kwangaphakathi).

Ngemva imithi ngokushesha kuthinta ukugeleza kwegazi, ukuthuthukisa ukukhuthazwa microcirculation futhi permeability we kwangaphakathi indlebe capillary. Futhi, ingxenye esebenzayo ye nomuthi uyakwazi ekulinganiseni ukugandeleleka cochlea endolymph.

Ngenxa yokuthi "Betahistine" kuyinto inhibitor ka H 3 receptor nuclei uhlelo vestibular, ke kunomphumela evelele phezu CNS. Ngakho, umuthi kubhekwa kuzole ukudluliswa (neuronal) izinzwa nucleus vestibular.

Nge umthamo ilungelo imithi, uyakwazi ukusiza ngokushesha olukwazi ukuqeda izibonakaliso inzululwane vestibular. Isikhathi ukuchayeka isithako esebenzayo zomuthi zokhahlamba kusuka imizuzu embalwa ngosuku olulodwa.

engayitholi njalo zomuthi ngaphansi kokuqondisa kukadokotela kunciphisa tigameko isiyezi, kunciphisa ikhala kanye enkeneneza ezindlebeni, futhi ubuyisela ukuzwa e ukuwohloka yayo.

Lo muthi ayinakho ukupholisa futhi akabubangeli abahluphayo nokubambisana.

izakhiwo pharmacokinetic

Izidakamizwa "Betagestin" kusukela inzululwane amuncwa umzimba ngokushesha futhi ngokuphelele. igazi lokuhlala wayo isiqongo siyithola ngemizuzu engaba ngu-65 ngemva kokuthatha izile ukudla.

Ingqikithi asebenzayo we nomuthi elihlobene ne amaprotheni ngaphansi kwama-5%.

Isuselwe izidakamizwa ukugaya ukuba metabolites ngasebenzi - demetilbetagistina 2-pyridylacetic acid. Ukuqedwa pheze ephelele izidakamizwa senzeka emini ngokusebenzisa izinso (90%). Ukuze asele 10%, basuke esaboniswa emathunjini.

izinkomba

Izidakamizwa "Betagestin" kusukela isiyezi iziguli babelwe kaningi impela. Ngaphezu kwalokho, izidakamizwa ezisetshenziselwa ukwelapha UMeniere Syndrome, kanye ukuqeda umsindo ezindlebeni, isicanucanu, ngokwengxenye ubuthulu nokuxhumana kahle.

Kufanele kuqashelwe ukuthi i-Meniere Syndrome sinezimfanelo njengoba iziyaluyalu sokuzwa kanye vestibular ezingafakwanga ngaphambilini ebonwe abantu. Iphinde kungavuka ifomu unhlangothi oyingozi. UMeniere Syndrome has awokuthi ukwehluleka njalo.

Izimo

Manje wazi kuzinjongo izidakamizwa isetshenziswa "Betagestin". Kusukela inzululwane kusindisa kahle. Nokho, lokhu izidakamizwa kukhona Izimo. Akumele elibekelwe abantu pheochromocytoma.

Kusukela izidakamizwa esebenzayo kuyinto analogue zokwenziwa of histamine, ukusetshenziswa kwalo kungase kube nomthelela ukukhululwa kwe catecholamines, okuyinto ke kuholela wegazi vele ophakeme kakhulu.

Kufanele kuqashelwe ukuthi le divayisi ye "betahistine" Tablets kuthiwa contraindicated in iziguli hypersensitivity kuya ingxenye esebenzayo, noma kunoma iyiphi enye excipients ngaphakathi yokwakheka izidakamizwa.

imiyalelo izidakamizwa

Izidakamizwa "Betagestin" kusukela inzululwane okufanele zithathwe ngokuqinile ngokuhambisana imiyalelo enikeziwe.

• Isikali sokuba iziguli omdala.

"Betahistine" amaphilisi iqondiswa ngesikhathi umthamo 8 noma 16 mg kathathu ngosuku (ekuqaleni ukwelashwa) kanye ukudla noma ngemva kwalo. Umthamo yesondlo kuyahlukahluka imithi 24-48 mg ngelanga (ngokuzikhethela kwe-udokotela).

Umthamo wansuku zonke zomuthi akufanele futhi iyophakama kuno-48 mg. It eqondiswa zonke nesineke ngabanye. Ngezinye izikhathi ngcono isimo sakhe kungabonakala nasemkhakheni kuphela ngemva kwamasonto ambalwa.

• Ukwelashwa kwabantu ngenhliziyo, izinso kanye yokwehluleka kwesibindi.

Ezigulini ezine-izifo ezifana izidakamizwa "Betahistine" angaqokwa kuphela ngemva ngihlolwa.

• Ukwelashwa nokuvikelwa asebekhulile.

Lapho esegugile, umuthi kufanele libekwe ngokucophelela okukhulu. Lokhu kungenxa yokuthi leli qembu iziguli kukhona amathuba ezinkulu amathuba okuba nemiphumela engemihle evela umzimba kuze izinto asizayo futhi esebenzayo, okuyiwona ayingxenye ebaluleke kakhulu ezibhebheni.

• Ukwelashwa kwezingane nentsha.

Izidakamizwa "Betagestin" kusukela inzululwane akukashicilelwa ukuba izingane nentsha (eneminyaka engaphansi kwengu 18). Lokhu kungenxa yokuntuleka nephephe imithi idatha.

amacala ukweqisa izidakamizwa

Uma ukweqisa izidakamizwa "Betahistine" Kwezinye iziguli ingase ibe nezimpawu ezifana isicanucanu, ikhanda ubuhlungu, ubuhlungu esiswini futhi ukozela (ngenkathi ethatha umthamo kuze kufinyelele 640 mg).

Futhi, iziguli zingase esekhala amajaqamba, ukuhlanza, dyspepsia, futhi ataxia.

Ukuze eziyingozi kakhudlwana zifaka yezinkinga eziphathelene nenhliziyo yamaphaphu (yabonakala ukweqisa izidakamizwa ngenhloso).

Ukwelashwa - ukugeza esiswini kungakapheli imizuzu 60 ngemva kokuphathwa.

side effects

Akubona bonke iziguli ukuthatha izidakamizwa "Betagestin", bangezwa ukungakhululeki.

Odokotela libike ukuthi ukubonakaliswa ukusabela ezingezinhle uma nithatha noma yimuphi umuthi isiguli kungasho yokuvumelana imithi emisha. Kule ndaba, qiniseka bonana nodokotela wakho kuqala ngaphambi ukuhoxiswa izidakamizwa.

Common side effects ekuthatheni "betahistine" kuphawula omunye in iziguli eziyishumi. Uhlu imiphumela ezivamile ukugula izimpawu ezifana:

• yisisu (ngokuvamile kwenzeka uma uthatha imithi ye-ngaphambi kokudla);
• ukucobeka jikelele;
• kabi noma ukuvuvukala;
• ukuphathwa ikhanda (ungathatha amaphilisi ezinhlungu, kodwa kuphela emva kokubonisana ngaphambi nge onguchwepheshe);
• komzimba esikhumbeni ngesimo ukulunywa futhi ukuqubuka (kufanele uthathe antihistamine noma amafutha inkinga ezindaweni amafutha okuthambisa).

Uma imihlahlandlela engenhla musa ukusiza ukuqeda imiphumela emibi, isiguli udinga ukubona udokotela.

I inani lentengo lomuthi

Inani "Betahistine" Tablets zingahluka futhi ancike inani imithi e iphakethe. Umuthi at umthamo 24 mg angathengwa ruble 60-65. iziguli eziningi zikholelwa ukuthi impela ongaphakeme izindleko izidakamizwa.

Uphenyo imithi

Uphenyo "Betahistine" ekwakhiweni kukhona okuxubile. Ezinye iziguli nge izifo zenhliziyo ezingamahlalakhona ukuthatha amaphilisi njalo. Nokho, abayivezi ngaso sonke isikhathi ukuqeda ubuhlungu bekhanda nesiyezi.

Futhi Izibuyekezo ezingezinhle futhi omuhle ngale nomuthi abonisa ukuthi sidinga isicelo esikhethekile.

Ngakho, lapho esinye ukuhlukumeza izidakamizwa "Betahistine" kusheshe ukubuyisela impilo isiguli, kuyilapho ezinye, kunalokho, akanawo nomphumela oyifunayo, kodwa ukunciphisa ukubonakala izimpawu nje kuphela.