Imidazoliletanamid pentandiovoy acid: kwemithi isinyathelo, isicelo, analogue

Uma udokotela wakho kwatholakala ukuthi nginesifo i "igciwane lohlobo", kusho ukuthi kudingeka aphathe ngendlela efanele. Iqembu kahle esikhulu ezakhamizi zethu nabo bakholelwa ukuthi imithi elwa namagciwane - ikhambi kangcono zonke izifo. Ngeshwa, akulona iqiniso ukulimaza okuningi ngaphandle isifo langempela. Imithi elwa namagciwane kuphela asebenzayo ngokumelene izifo ezibangelwa amagciwane, kodwa amandla kawakho amagciwane.

Kanjani imisebenzi izidakamizwa?

Ziningi kakhulu inani elikhulu izidakamizwa nomsebenzi namagciwane. Omunye izinto ezivame kakhulu ukuthi ube le impahla - ke imidazoliletanamid pentandiovoy acid.

Kuyinto asebenzayo emagciwaneni izinhlobo Umkhuhlane A no-B, adenovirus, parainfluenza futhi kusiza zokuphefumula syncytial virus ukutheleleka.

Le ngxube abaphuma njalo seliphindeke izikhathi indlela eyingqayizivele senzo. It kuvimbela nekutala amagciwane ikhenela isigaba esiteji futhi retards yokufuduka ejenti esanda ezithathelwanayo kusukela cytoplasmic imvelo Nucleus amaseli.

Futhi pentandiovoy imidazoliletanamid acid is bahileleke amasosha omzimba womuntu, nokunikeza umphumela modulating. Ingqikithi kwandisa igazi interferon okuqukethwe ezingeni kuyinsakavukela bokuphila. futhi kuvusa inqubo α-, leukocyte γ-interferonproduktsii, okuholela isimo ohambelana le misebenzi.

Uphenyo we ketshezi esebenzayo wabonisa ukuthi imidazoliletanamid pentandiovoy acid ikhuthaza isizukulwane cytotoxic lymphocyte senzo. Ngaphezu kwalokho, it kwandisa isibalo NK-T-ejenti ukuthi unekhono okungenakuqhathaniswa ukuze kubulawe amangqamuzana siguqulwe nge amagciwane, kanye isenzo ngqo ku Amagciwane.

Inzuzo kuyinto nokuba khona izidakamizwa kwadingeka izakhiwo eqeda ukuvuvukala. Basuke olunikezwa abacindezela ukukhiqizwa iphrofayli cytokines, kanye ukwehla umsebenzi myeloperoxidase enzyme.

nomphumela oqabulayo

Imidazoliletanamid pentandiovoy acid, ukubuyekezwa zazo akhayo, elandelayo ikhombisa nomphumela oqabulayo ekwelapheni SARS kanye Umkhuhlane:

• Kunciphisa isikhathi yenqubo febrile.
• Yehlisa izimpawu zokudakwa (isiyezi, ubuhlungu, ubuthakathaka).
• Yehlisa catarrhal ukubonakaliswa.
• Kwehlisa yezinkinga nalesi sifo.
• Kunciphisa Isikhathi sokugula.

Izidakamizwa nge imidazoliletanamidom pentandiovoy acid

Ekhemisi zingatholakala the ukwakhiwa elandelayo equkethe imidazoliletanamid pentandiovoy acid:

• "Vitaglutam" izimpushana.
• "Ingavirin" ngesimo amaphilisi.
• "Dicarbamine" amaphilisi-mbumbulu.

Izimo

Njenganoma iyiphi izidakamizwa imidazoliletanamid pentandiovoy acid - umuthi okumele kuphethwe udokotela ukuba khona. Lo mkhiqizo ezithaka imithi has Izimo, kuhlanganise:

• Phakathi nokukhulelwa kanye lactation.
• Izingane ezineminyaka engu-18.
• Hypersensitivity izingxenye izidakamizwa.

Imiphumela engemihle evela imithi eliqukethe echazwe izidakamizwa esebenzayo ungaboniswa ngesimo ukusabela nomzimba.

Lo mphumela inikezwe ukuthi umuntu ezwela ngabanye ukuba imidazoliletanamidu pentandiovoy izinto acid noma asizayo, okuyiwona ayingxenye ebaluleke kakhulu izidakamizwa.

ukuphepha

Abanye abantu bazame ukugwema ukusetshenziswa kwalesi izidakamizwa, bekholelwa ukuthi imidazoliletanamid pentandiovoy acid - kuyinto antibiotic. Lokhu Ukubuka iphutha, ngoba yalolu ketshezi asebenzayo liveza umsebenzi elwa namagciwane kuphela. izinga Ngokuthi phuca kuye kuzo zonke imiphumela engemihle esivela iphrofayela izidakamizwa elwa namagciwane. Umuthi ayinakho isinyathelo immunotoxic, umdlavuza, mutagenic noma allergenic ngaphandle abakucasulayo ipheshana yesisu kungukuthi encishisiwe umsebenzi zokuzala ayinakho embryotoxic noma umphumela teratogenic.

Ophawuleka umsebenzi kunalokho okusezingeni eliphezulu izidakamizwa ukuthi yakhiwa imidazoliletanamid pentandiovoy analogs acid zazo esithathwa ngomlomo. Basuke ngokushesha ugxile pheshana emathunjini futhi ngokulinganayo basakaza e kwezitho nezicubu. Kakade emva isigamu sehora ngemva ukungenisa isithako okwelapha ifinyelela lokuhlushwa wobuningi egazini futhi aphethwe amahora 37. Isikhathi ukwelashwa kwaba izinsuku 5. ekuphathweni ngamunye zomuthi gxuma kwayo okuqukethwe egazini, okuyinto incipha kancane emini. Umuthi emzimbeni womuntu akuyona akheka okukhipha ingashintshiwe nge izinso namathumbu.

sici reception

Kubalulekile ukugcina umthamo lwemithi zomuthi. Imidazoliletanamid pentandiovoy analogs acid zinezikhathi cishe izincomo efanayo ukusetshenziswa, kufanele kudliwe ngomlomo kanye ngosuku e isamba 90 mg phezu esiyizinsuku ezingu 5-7 ka, kungakhathaliseki ukuthi ukudla.

I engavamile walesi impatho-ejenti ezenza imithi ukuthi kahle enkulu kuba yipumelelo lokha sanikezwa ngemva uzingela izimpawu zokuqala zesifo ezinsukwini ezimbili zokuqala.

"Vitaglutam" - umthombo kuneqembu labasebenzi namagciwane

Umlando zomuthi iphindela 70s kwekhulu elidlule. Lwakhiwe nge edumile Russian udokotela Pulmonologist Alexander Chuchalin. I nomuthi yakhiwa njengendlela eyinhloko esebenzayo isithako imidazoliletanamid pentandiovoy acid. "Vitaglutam" laqanjwa ngaphansi kwegama ukuhweba "Dicarbamine" kuze 2008. Injongo yakhe kwakuwukumkhulula ukuthi, ukugqugquzela inqubo hematopoiesis ezigulini eziye zabhekana ukwelashwa ukwelashwa somdlavuza.

Ngo-2009, isintu sibhekene esibi virus ukutheleleka - umkhuhlane wezingulube, noma A / H1N1. Ngalesi sikhathi, "ukuthuthukiswa Vitaglutama 'bebelokhu efanele kakhulu. Aleksandr Chuchalin, owayeneminyaka ngaleso sikhathi udokotela omkhulu we-Russian Federation, wanquma ukuhlola indalo yakhe ngokumelene ezingulubeni umkhuhlane virus futhi uzuze imiphumela yimpumelelo. Wathi womkhiqizo wakuleli, ogxile imidazoliletanamid pentandiovoy acid, "Vitaglutam" sikhombisa ngempumelelo enkulu ezifweni esesabekayo kuka wemithi umkhiqizo American "Tamiflu". Yena ngenkuthalo bafakwe ufuzo viral, alibulale.

Impilo Entsha "Vitaglutam" isidakamizwa "Ingavirin"

Chuchalin ezihlongozwayo Gennady Onishchenko, induna udokotela sanitary we Russian Federation, ukusebenzisa indlela yakhe njengethuluzi eliphumelelayo ekwelapheni umkhuhlane wezingulube. Ngenxa zokwelapha zomuthi sezenziwe, lapho baqinisekisa ekulenzeni libe namandla ngenhlonipho umuntu ezifweni ezihlukahlukene ezibangelwa amagciwane. Umuthi wanikezwa igama elisha "Ingavirin" futhi yabhaliswa encwadini okubhalwa kuyo iqembu izidakamizwa elwa namagciwane futhi immunostimulatory.

Uma lo mkhiqizo inkampani eyenza imithi "Valenta" Waqhubeka ukudayiswa, kwathiwa ngokusemthethweni ezinconywe uMnyango wezeMpilo njengendlela yokwelapha for umkhuhlane wezingulube futhi yamshaya amarekhodi udumo phakathi kwabantu. Ngakho, singasho mayelana ukufana "Dicarbamine" - imidazoliletanamid pentandiovoy acid - "Vitaglutam", okungukuthi, e umuthi ofanayo Eqinisweni, omunye futhi.

Kuyaphawuleka ukuthi "Ingavirin" Waqhubeka ukudayiswa ngo-2008 wenza kwahambisana noshushiso umnyuziki emtholampilo. Ngosizo Onishchenko ngo-2009 kwadlanga kakhulu zokwelapha ku amagundane laboratory ayehlelwe. Futhi kulesi sehlakalo, ubuhanjelwe iziguli 100 iqhaza. Ngokusekelwe imiphumela iqembu lesifundo kwaholela Chuchalin lwaphetha ngokuthi "Ingavirin" emahoreni lokuqala 48 kusukela ekuqaleni ukutheleleka yabonisa kahle kuqhathaniswa okusezingeni eliphezulu isifo Amagciwane. isenzo sayo kubonakala wokwehla isikhathi febrile, nokuncipha ubuthi e izilwane zokucwaninga kanye neziguli kanye ukunciphisa ukubonakaliswa catarrhal.

Ngakho-ke, asikho isizathu sokuba acabange ngaleyo imidazoliletanamid pentandiovoy acid okungukuthi dummy - ekulenzeni libe namandla kungase kutholakale emtholampilo.

"Dicarbamine" namuhla

Okwamanje, bonke izidakamizwa ezintathu ngesisekelo imidazoliletanamida pentandiovoy acid okudayiswayo akhona futhi isebangeni njengoba nozakwabo komunye nomunye.

"Dicarbamine" Kunconywa ukuba isetshenziswe iziguli nokuba khona izimila ebulalayo. Ngaphezu isithako esebenzayo eyinhloko, uqukethe ubisi noshukela, talc, amazambane isitashi, magnesium stearate, isixazululo colloidal ka-silicon dioxide futhi stearic acid.

"Dicarbamine" has miphumela elandelayo zokwelapha:

• Ukusheshisa neutrophil kwamangqamuzana kanye nokuvuthwa sokusebenza.
• Gematoprotektsiya nokwelashwa ngamakhemikhali myelosuppressive.
• Ukunciphisa imvamisa nesenzakalo lobulukhuni neutropenia anobuthi, leukopenia nokukhawulela.

Lokhu ukulungiselela Kunconywa ukusebenzisa phakathi izifundo ngamakhemikhali.

ukusebenza kwalo isivele sobala emva kwezinsuku 21-28 yokuphathwa nsuku zonke amaphilisi.

A umthamo owodwa we imithi - 100 mg (1 tablet) - kuthathwe izinsuku 5 ngaphambi kokuqala ngamakhemikhali futhi kwaqhubeka phakathi nayo yonke ukwelashwa. "Dicarbamine" has impahla ukukhuthaza nokulondoloza isenzo anticancer cytotoxic izidakamizwa, ukunciphisa imiphumela ezinobuthi of cyclophosphamide nezidakamizwa-platinum based, futhi kuholele izinqubo evamile hematopoiesis.